2023 Vol. XXVIII N 4

: Hits: 1175

Medicni perspektivi. 2023. Vol. 28, N 4

2023 Vol. XXVIII N 4

Published
2023-12-22

THEORETICAL MEDICINE

Chernyaeva A.O., Mykytyuk M.R., Karachentsev Yu.I. Analysis of parameters of purine metabolism in patients with diabetes mellitus type 2

https://doi.org/10.26641/2307-0404.2023.4.293972

Abstract

The aim of this research is to comprehensively analyze the current state of purine metabolism as well as assess its features in patients with diabetes mellitus type 2, taking into account the clinical and metabolic polymorphism of the disease. The authors examined 327 patients with diabetes mellitus type 2 (144 men and 183 women), a group of individuals with an average age of 57.8±10.1 years. The average duration of the disease was (9.3±7.3) years. All subjects received oral hypoglycemic therapy. The researchers determined anthropometric indicators, indicators of carbohydrate metabolism, concentration of creatinine, uric acid, parameters of the blood lipid spectrum, purine bases, activity of xanthine oxidase and hypoxanthine-guanine-phosphoribosyltransferase in the blood. In the course of the study the authors verified excretion of uric acid and creatinine renal uric acid, fractional clearance of uric acid, total tubular reabsorption of uric acid and coefficient of complete degradation of purine bases. Using the software complex "Statgraphics Centurion 18.0", we statistically analyzed the obtained data. The research showed that a decrease in assimilation, increased oxidation of purine bases due to the activation of xanthine oxidase, and a decrease in their reutilization by inhibiting the activity of hypoxanthine-guanine-phosphoribosyltransferase cause the high intensity of purine catabolism in patients with diabetes mellitus type 2. Hyperuricemia (28.0%), increased creatinine renal uric acid (62.3%), increased coefficient of complete degradation of purine bases (41.6%), activity of xanthine oxidase (38.8%) and inhibition of hypoxanthine-guanine-phosphoribosyltransferase activity (50.3%) dominate in the structure of disorders of purine bases in patients with diabetes mellitus type 2. We found that more than 50% of the subjects had high concentrations of purine bases in the blood. Purine bases concentrations in the blood of patients with diabetes mellitus type 2 closely correlate with each other and with the activity of xanthine oxidase and do not correlate with the level of uricemia, the level of uricemia does not correlate with the level of uric acid excretion. That is, the concentration of uric acid in the blood of patients with diabetes mellitus type 2 does not objectively reflect its production in the body. Patients with diabetes mellitus type 2 with obesity associate hyperuricemia with significantly lower creatinine renal uric acid and fractional clearance of uric acid as well as activation of the anabolic pathway of purine bases deposition.

Key words: type 2 diabetes, obesity, uric acid, purine metabolism

References

Yu W, Cheng JD. Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective. Front Pharmacol. 2020;11:582680. doi: https://doi.org/10.3389/fphar.2020.582680
Yip K, Cohen RE, Pillinger MH. Asymptomatic hyperuricemia: is it really asymptomatic? Curr Opin Rheumatol.2020;32(1):71-9. doi: https://doi.org/10.1097/BOR.0000000000000679
Li B, Chen L, Hu X, et al. Association of Serum Uric Acid With All-Cause and Cardiovascular Mortality in Diabetes. Diabetes 2023;46(2):425-33. doi: https://doi.org/10.2337/dc22-1339
Jiao Z, Chen Y, Xie Y, Li Y, Li Z. Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo. J Cell Mol Med. 2021;25(14):6733-45. doi: https://doi.org/10.1111/jcmm.16677
Lu J, He Y, Cui L, et al. Hyperuricemia Predisposes to the Onset of Diabetes via Promoting Pancreatic β-Cell Death in Uricase-Deficient Male Mice. Diabetes. 2020;69(6):1149-63. doi: https://doi.org/10.2337/db19-0704
Ghasemi A. Uric acid-induced pancreatic β-cell dysfunction. BMC Endocr Disord. 2021;21(1):24. doi: https://doi.org/10.1186/s12902-021-00698-6
Russo E, Viazzi F, Pontremoli R, et al. Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project. J Nephrol.2022;35(1):211-21. doi: https://doi.org/10.1007/s40620-021-00985-4
Cherniaieva AO. [Hyperuricemia as a marker of the intensity of lipid peroxidation in the population]. Aktualni problemy suchasnoi medytsyny: Visnyk Ukrainskoi medychnoi stomatolohichnoi akademii. 2020;20(3):152-8. Ukrainian. doi: https://doi.org/10.31718/2077-1096.20.3.152
Furuhashi M. New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity. Am J Physiol Endocrinol Metab. 2020;319(5):E827-34. doi: https://doi.org/10.1152/ajpendo.00378.2020
Bayot ML, Lopes JE, Naidoo P. Clinical Laboratory. 2022. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Feb 14]. PMID: 30570979.Available from: https://pubmed.ncbi.nlm.nih.gov/30570979/
Kozarich JW. Welcome to Biochemistry Volume 1: No Hyphen Required. Biochemistry. 2021;60(46):3427-8. doi: https://doi.org/10.1021/acs.biochem.1c00569
Hricovíni M, Owens RJ, Bak A, et al. Chemistry towards Biology-Instruct: Snapshot. Int J Mol Sci. 2022;23(23):14815. doi: https://doi.org/10.3390/ijms232314815
Honskyi YaI, Maksymchuk TP. [Human biochemistry: a textbook]. Ternopil: TDMU; 2019. 732 р. Ukrainian.
Kawaguchi M, Taniguchi A. [Life-oriented Chemistry in Pharmaceutical Sciences]. Yakugaku Zasshi. 2019;139(2):261-2. doi: https://doi.org/10.1248/yakushi.18-00174-F
Schepartz A. Introducing "Future of Biochemistry: The International Issue". Biochemistry. 2019;58(1):1-6. doi: https://doi.org/10.1021/acs.biochem.8b01293
Matli B, Schulz A, Koeck T, et al. Distribution of HOMA-IR in a population-based cohort and proposal for reference intervals. Clin Chem Lab Med. 2021;59(11):1844-51. doi: https://doi.org/10.1515/cclm-2021-0643
Shi J, Lindo EG, Baird GS, et al. Calculating estimated glomerular filtration rate without the race correction factor: Observations at a large academic medical system. ClinChim 2021;520:16-22. doi: https://doi.org/10.1016/j.cca.2021.05.022
Townsend MH, Tellez Freitas CM, Larsen D, et al. Hypoxanthine Guanine Phosphoribosyltransferase expression is negatively correlated with immune activity through its regulation of purine synthesis. Immunobiology. 2020;225(3):151931. doi: https://doi.org/10.1016/j.imbio.2020.151931
Choi ST, Song JS, Kim SJ, et al. The Utility of the Random Urine Uric Acid-to-Creatinine Ratio for Patients with Gout Who Need Uricosuric Agents: Retrospective Cross-Sectional Study. J Korean Med Sci. 2020;35(13):e95. doi: https://doi.org/10.3346/jkms.2020.35.e95
Peacock JL, Peacock PL. Oxford Hadbook of Medical Statistics. 2nd ed. Oxford University Press, UK; 2020. 640 p. doi: https://doi.org/10.1093/med/9780198743583.001.0001
Su H, Liu T, Li Y, et al. Serum uric acid and its change with the risk of type 2 diabetes: A prospective study in China. Prim Care Diabetes. 2021;15(6):1002-6. doi: https://doi.org/10.1016/j.pcd.2021.06.010
Zinych O, Shuprovych A, Prybyla O, et al. [Peculiarities of the anabolic-catabolic balance of purines in patients with type 2 diabetes with different metabolic phenotypes]. Рroblemy endokrynnoi patolohii. 2023;80(1):22-9. Ukrainian. doi: https://doi.org/10.21856/j-PEP.2023.1.03
Liu J, Chen L, Yuan H, et al. Survey on uric acid in Chinese subjects with essential hypertension (SUCCESS): a nationwide cross-sectional study. Ann Transl 2021;9(1):27. doi: https://doi.org/10.21037/atm-20-3458
Woyesa SB, Hirigo AT, Wube TB. Hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients at Hawassa university comprehensive specialized hospital, South West Ethiopia. BMC Endocr Disord. 2017;17(1):76. doi: https://doi.org/10.1186/s12902-017-0226-y
Zhang Q, Zhang C, Song X, et al. A longitudinal cohort based association study between uric acid level and metabolic syndrome in Chinese Han urban male population. BMCPublic 2012;12:419. doi: https://doi.org/10.1186/1471-2458-12-419
Li C, Hsieh MC, Chang SJ. Metabolic syndrome, diabetes, and hyperuricemia. Curr Opin Rheumatol. 2013;25(2):210-6. doi: https://doi.org/10.1097/BOR.0b013e32835d951e/
İnanir M. Serum uric acid (SUA) in morbidly obese patients and its relationship with metabolic syndrome. Aging 2020;23(5):1165-9. doi: https://doi.org/10.1080/13685538.2020.1713742/
Li W, Wang Y, Ouyang S, et al. Association Between Serum Uric Acid Level and Carotid Atherosclerosis and Metabolic Syndrome in Patients With Type 2 Diabetes Mellitus. Front Endocrinol (Lausanne). 2022;13:890305. doi: https://doi.org/10.3389/fendo.2022.890305

PDF

Authors and affiliations

Cite

Metrics

Melnychuk I.O., Lyzogub V.H. Plasma amino acids spectrum as an important part of metabolomic pattern in patients with coronary artery disease and atrial fibrillation

https://doi.org/10.26641/2307-0404.2023.4.293976

Abstract

References

Chen MX, Wang SY, Kuo CH, Tsai Metabolome analysis for investigating host-gut microbiota interactions. J Formos Med Assoc. 2019;118(1):S10-S22. doi: https://doi.org/10.1016/j.jfma.2018.09.007
Duttaroy Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review. Nutrients. 2021;13(1):144. doi: https://doi.org/10.3390/nu13010144
BreitS, Kupferberg A, Rogler G, Hasler Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders. Front Psychiatry. 2018;9:44. doi: https://doi.org/10.3389/fpsyt.2018.00044
Lizogub VG, Kramarova VN, Melnychuk IO. The role of gut microbiota changes in the pathogenesis of heart disease. Zaporizkiy medical journal. 2019;21(5-116):672-8. doi: https://doi.org/10.14739/2310-1210.2019.5.179462
WangZ, Zhao Gut microbiota derived metabolites in cardiovascular health and disease. Protein Cell. 2018;9(5):416-31.
doi: https://doi.org/10.1007/s13238-018-0549-0
AgusA, Clément K, Sokol Gut microbiota-derived metabolites as central regulators in metabolic disorders. Gut. 2021;70(6):1174-82. doi: https://doi.org/10.1136/gutjnl-2020-323071
ZhangX, Gérard Diet-gut microbiota interactions on cardiovascular disease. Comput Struct Biotechnol J. 2022;20:1528-40. doi: https://doi.org/10.1016/j.csbj.2022.03.028
Kornej J, Hanger VA, Trinquart L, et al. New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation. Cardiovasc Res. 2021;117(7):1632-44. doi: https://doi.org/10.1093/cvr/cvab073
SheJ, Guo M, Li H, Liu J, Liang X, Liu P, et al. Targeting amino acids metabolic profile to identify novel metabolic characteristics in atrial fibrillation. Clin Sci (Lond). 2018;132(19):2135-46. doi: https://doi.org/10.1042/CS20180247
HarskampRE, Granger TM, Clare RM, White KR, Lopes RD, Pieper KS, et all. Peripheral blood metabolite profiles associated with new onset atrial fibrillation. Am Heart J. 2019;211:54-9. doi: https://doi.org/10.1016/j.ahj.2019.01.010
Liu W, Zhang L, Shi X, Shen G, Feng Cross-comparative metabolomics reveal sex-age specific metabolic fingerprints and metabolic interactions in acute myocardial infarction. Free Radic Biol Med. 2022;183:25-34. doi: https://doi.org/10.1016/j.freeradbiomed.2022.03.008
CaiD, Hou B, Xie Amino acid analysis as a method of discovering biomarkers for diagnosis of diabetes and its complications. Amino Acids. 2023 May;55(5):563-78. doi: https://doi.org/10.1007/s00726-023-03255-8
Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomstrom-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). European Heart Journal. 2020;42:373498. doi: https://doi.org/10.1093/eurheartj/ehaa612
Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal. 2020;41:407477. doi: https://doi.org/10.1093/eurheartj/ehz425
Gałęzowska G, Ratajczyk J, Wolska L. Determination of amino acids in human biological fluids by high-performance liquid chromatography: critical review. Amino Acids. 2021;53(7):993-1009. doi: https://doi.org/10.1007/s00726-021-03002-x
Nafis F, Alvi Y. Biostatistics Manual for Health Research. Elsevier; 2023 April 19. ISBN: 9780443185502.
Nahm FS. Receiver operating characteristic curve: overview and practical use for clinicians. Korean J Anesthesiol. 2022;75(1):25-36. doi: https://doi.org/10.4097/kja.21209
Xiong Y, Jiang L, Li T. Aberrant branched-chain amino acid catabolism in cardiovascular diseases. Front Cardiovasc Med. 2022;9:965899. doi: https://doi.org/10.3389/fcvm.2022.965899
Melnychuk IO, Sharaeva ML, Kramarova VN, Lyzogub VH. Prospects for the sulfur-containing amino acids medicines usage for trimethylamine-N-oxide biosynthesis modulation in humans. Pathology. 2022;19(3-56):247-55. doi: https://doi.org/10.14739/2310-1237.2022.3.263564
Azab SM, Shanmuganathan M, Souza RJ, Kroezen Z, Desai D, Williams NC, et al. Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis. BMC Med. 2023;21:176. doi: https://doi.org/10.1186/s12916-023-02886-8
Razquin C, Ruiz-Canela M, Toledo E, Clish CB, Guasch-Ferré M, García-Gavilán JF, et al. Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial. Int J Mol Sci. 2023;24(1):270. doi: https://doi.org/10.3390/ijms24010270
Zhang Y, He X, Qian Y, Xu S, Mo C, Yan Z, et al. Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease. NPJ Parkinsons Dis. 2022;8:48. doi: https://doi.org/10.1038/s41531-022-00312-z
McGarrah RW, White PJ. Branched-chain amino acids in cardiovascular disease. Nat Rev Cardiol. 2023 Feb;20(2):77-89. doi: https://doi.org/10.1038/s41569-022-00760-3
Xu Y, Jiang H, Li L, Chen F, Liu Y, Zhou M, et al. Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets. Circulation. 2020 Jul 7;142(1):49-64. doi:https://doi.org/10.1161/CIRCULATIONAHA.119.043581
Jian H, Miao S, Liu Y, Wang X, Xu Q, Zhou W, et al. Dietary Valine Ameliorated Gut Health and Accelerated the Development of Nonalcoholic Fatty Liver Disease of Laying Hens. Oxid Med Cell Longev. 2021 Aug 23;2021:4704771. doi: https://doi.org/10.1155/2021/4704771
Liu Y, Hou Y, Wang G, Zheng X, Hao H. Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host-Microbe Interplay. Trends Endocrinol Metab. 2020 Nov;31(11):818-34. doi: https://doi.org/10.1016/j.tem.2020.02.012
Perna S, Alalwan TA, Alaali Z, Alnashaba T, Gasparri C, Infantino V, et al. The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review. Int J Mol Sci. 2019 Oct 22;20(20):5232. doi: https://doi.org/10.3390/ijms20205232
Starreveld R, Ramos KS, Muskens AJ, Brundel BJ, de Groot NM. Daily Supplementation of L-Glutamine in Atrial Fibrillation Patients: The Effect on Heat Shock Proteins and Metabolites. Cells. 2020 Jul 20;9(7):1729. doi: https://doi.org/10.3390/cells9071729
Alves A, Bassot A, Bulteau AL, Pirola L, Morio B. Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. Nutrients. 2019;11(6):1356. doi: https://doi.org/10.3390/nu11061356

PDF

Authors and affiliations

Cite

Metrics

Krasnoselskyi M.V., Kyrylova O.O., Dubenko O.Ye., Rublova T.V., Pavlichenko Yu.V. Risks of psychological traumatization and stress adaption of medical staff working under war conditions (analytical literature review)

https://doi.org/10.26641/2307-0404.2023.4.293979

Abstract

Medical and psychological consequences of war have a destructive impact on mental health during the hostilities and after their cessation and determine a wide variety of different psychogenic disorders in an individual who was in the territory of hostilities. The purpose of the work is to analyze and summarize scientific literature data on the issue of mental traumatization of the medical staff under the conditions of working during war conflicts. The article is concerned with the analytical literature review, the analysis of experience of studying features of psychoemotional state of the medical workers and people who were in the territory of hostilities, and delivering medical and psychological aid to them. The features of psychological responsiveness of the individuals who participated in war conflicts and possible consequences of mental health damage are described. Scientific data on mental state of medical staff working under the conditions of the war conflict are limited. Most studies are concerned with military personnel and civilians. During war conflicts, medical workers face with chronic stress factors and take their own personal risk that may lead to deterioration of mental health, including post-traumatic stress disorder. International studies have shown that, regardless of the specialty, doctors who are working in stress situations, including war, have an increased risk of depression compared to civil population in general due to high risk of burnout. The incidence of depression among doctors ranges from 11% to 47%. Military medics can suffer severe stress due to the increased risk of death or injuries of other people, and they are also directly or indirectly impacted by a common traumatic reality. The impact of injuries, deaths, sexual assaults, and personal threats jeopardize health of combat nurses who participate in military, humanitarian, and aid missions after natural disasters. As a result, they suffer from unfavorable mental consequences. Compassion fatigue, exhaustion, and post-traumatic stress disorder are common. The importance of medical and psychological aid aimed at decreasing stress and stabilizing psychoemotional state of the medical staff who are working under the conditions of war led to development of a large number of programs in various psychotherapeutic areas that have shown their high effectiveness.

Key words: war conflict, war, mental traumatization, medical staff, coping strategies, distress, adaptation

References

Prykhodko II, Bielai1 SV, Hrynzovskyi AM, et al. Medical and psychological aspects of safety and adaptation of military personnel to extreme conditions. Wiad Lek. 2020;73(4):679-83. doi: https://doi.org/10.36740/WLek202004110
Have HT. Bioethics and War. Hastings Cent Rep. 2023;53(3):2. doi: https://doi.org/10.1002/hast.1482
Lim AG, Stock L, Shwe OEK, Jutte DP. Trauma and mental health of medics in eastern Myanmar’s conflict zones: a cross-sectional and mixed methods investigation. Confl 2013;7(1):15. doi: https://doi.org/10.1186/1752-1505-7-15
Fontanarosa PB, Flanagin A, Golub RM. Catastrophic health consequences of the war in Ukraine. JAMA. 2022;327(16):1549-50. doi: https://doi.org/10.1001/jama.2022.6046
Hăisan A, Măirean C, Lupuşoru SI, Tărniceriu C, Cimpoeşu D. General Health among Eastern Romanian Emergency Medicine Personnel during the Russian-Ukrainian Armed Conflict. Healthcare (Basel). 2022;10(10):1976. doi: https://doi.org/10.3390/healthcare10101976
Oviedo L, Seryczyńska B, Torralba J, et al. Coping and Resilience Strategies among Ukraine War Refugees. Int J Environ Res Public Health. 2022;19(20):13094. doi: https://doi.org/10.3390/ijerph192013094
Saxon L, Makhashvili N, Chikovani I, et al. Coping strategies and mental health outcomes of conflict-affected persons in the Republic of Georgia. Epidemiol Psychiatr 2017;26(3):276-86. doi: https://doi.org/10.1017/S2045796016000019
Chikovani I, Makhashvili N, Gotsadze G, et al. Health service utilization for mental, behavioural and emotional problems among conflict-affected population in Georgia: a cross-sectional study. PLoS One. 2015;10(4):e0122673. doi: https://doi.org/10.1371/journal.pone.0122673
Wildt H, UmanosJ, Khanzada NK, et al. War Trauma, Psychological Distress, and Coping Among Afghan Civilians Seeking Primary Health Care. Int Perspec Psychol. 2017;6(2):81-100. doi: https://doi.org/10.1037/ipp0000065
Sharma M, Fine SL, Brennan RT, Betancourt TS. Coping and mental health outcomes among Sierra Leonean war-affected youth: Results from a longitudinal study. Dev Psychopathol. 2017;29(1):11-23. doi: https://doi.org/10.1017/S0954579416001073
Peterson AL, Blount TH, Foa EB, et al. Massed vs Intensive Outpatient Prolonged Exposure for Combat-Related Posttraumatic Stress Disorder: A Randomized Clinical Trial. JAMA Netw Open. 2023;6(1):e2249422. doi: https://doi.org/10.1001/jamanetworkopen.2022.49422
Schnurr PP, Chard KM, Ruzek JI, et al. Comparison of Prolonged Exposure vs Cognitive Processing Therapy for Treatment of Posttraumatic Stress Disorder Among US Veterans: A Randomized Clinical Trial. JAMA Netw Open. 2022;5(1):e2136921. doi: https://doi.org/10.1001/jamanetworkopen.2021.36921
Breneman CB, Reinhard MJ, Allen N, et al. Gulf War Illness: A Randomized Controlled Trial Combining Mindfulness Meditation and Auricular Acupuncture. Glob Adv Integr Med Health. 2023;12:27536130231171854. doi: https://doi.org/10.1177/27536130231171854
Hynes C, Scullion L, Lawler C, Steel R, Boland P. The impact of in-service physical injury or illness on the mental health of military veterans. BMJ Mil Health. 2023;169(e1):e51-e54. doi: https://doi.org/10.1136/bmjmilitary-2020-00175
Hawari RJ, McCabe CT, Dougherty AL, et al. Transport time after combat-related injury and patient-reported outcomes among US service members. BMJ Mil Health. 2023;169(e1):e34-e38. doi: https://doi.org/10.1136/bmjmilitary-2020-001542
Abdallah CG, Roache JD, Gueorguieva R, et al. Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial. Neuropsychopharmacology. 2022;47(8):1574-81. doi: https://doi.org/10.1038/s41386-022-01266-9
Peterson AL, Niles BL, Young-McCaughan S, Keane TM. Assessment and Treatment of Combat-Related Posttraumatic Stress Disorder: Results from STRONG STAR and the Consortium to Alleviate PTSD In: Current Topics on Military Medicine [Internet]. Intech Open; 2021 [cited 2023 Jul 12]. doi: http://dx.doi.org/10.5772/intechopen.96323
Ragsdale KA, Watkins LE, Sherrill AM, Zwiebach L, Rothbaum BO. Advances in PTSD treatment delivery: evidence base and future directions for intensive outpatient programs. Curr Treat Options Psychiatry. 2020;7:291-300. doi: https://doi.org/10.1007/s40501-020-00219-7
Johnston JN, Henter ID, Zarate CA Jr. The antidepressant actions of ketamine and its enantiomers. Pharmacol Ther. 2023;246:108431. doi: https://doi.org/10.1016/j.pharmthera.2023.108431
Stanley IH, Rogers ML, Hanson JE, Gutierrez PM, Joiner TE. PTSD symptom clusters and suicide attempts among high-risk military service members: A three-month prospective investigation. J Consult Clin Psychol. 2019;87(1):67-78. doi: https://doi.org/10.1037/ccp0000350
Doody CB, Robertson L, Cox KM, Bogue J, Egan J, Sarma KM. Pre-deployment programmes for building resilience in military and frontline emergency service personnel. Cochrane Database Syst Rev. 2021;12(12):CD013242. doi: https://doi.org/10.1002/14651858.CD013242.pub2
Pruiksma KE, Taylor DJ, Wachen JS, et al. Self-reported sleep problems in active-duty US Army personnel receiving posttraumatic stress disorder treatment in group or individual formats: secondary analysis of a randomized clinical trial. J Clin Sleep Med. 2023;19(8):1389-98. doi: https://doi.org/10.5664/jcsm.10584
Simon N, Robertson L, Lewis C, et al. Internet-based cognitive and behavioural therapies for post-traumatic stress disorder (PTSD) in adults. Cochrane Database Syst Rev. 2021;5(5):CD011710. doi: https://doi.org/10.1002/14651858.CD011710.pub3
Pollock A, Campbell P, Cheyne J, et al. Interventions to support the resilience and mental health of frontline health and social care professionals during and after a disease outbreak, epidemic or pandemic: a mixed methods systematic review. Cochrane Database Syst Rev. 2020;11(11):CD013779. doi: https://doi.org/10.1002/14651858.CD013779
Peterson AL. General Perspective on the U.S. Military Conflicts in Iraq and Afghanistan after 20 years. Mil Med. 2022;187(9-10):248-51. doi: https://doi.org/10.1093/milmed/usab496
McGeary DD, Resick PA, Penzien DB, et al. Cognitive Behavioral Therapy for Veterans With Comorbid Posttraumatic Headache and Posttraumatic Stress Disorder Symptoms: A Randomized Clinical Trial. JAMA Neurol. 2022;79(8):746-57. doi: https://doi.org/10.1001/jamaneurol.2022.1567
Korgaonkar MS, Felmingham KL, Malhi GS, Williamson TH, Williams LM, Bryant RA. Changes in neural responses during affective and non-affective tasks and improvement of posttraumatic stress disorder symptoms following trauma-focused psychotherapy. Transl Psychiatry. 2023;13(1):85. doi: https://doi.org/10.1038/s41398-023-02375-9
Brynhildsvoll Auren TJ, Gjerde Jensen A, Rendum Klæth J, Maksic E, Solem S. Intensive outpatient treatment for PTSD: a pilot feasibility study combining prolonged exposure therapy, EMDR, physical activity, and psychoeducation. Eur J Psychotraumatol. 2021;12(1):1917878. doi: https://doi.org/10.1080/20008198.2021.1917878
Peterson AL, Foa EB, Riggs DS. Prolonged exposure therapy. In: Moore BA, Penk W, eds. Treating PTSD in Military Personnel: A Clinical Handbook. 2nd ed. Guilford Press; 2019. p. 46-62.
Peterson AL, Young-McCaughan S, Roache JD, et al. STRONG STAR and the Consortium to Alleviate PTSD: Shaping the future of combat PTSD and related conditions in military and veteran populations. Contemp Clin Trials. 2021;110:106583. doi: https://doi.org/10.1016/j.cct.2021.106583
Brown LA, Clapp JD, Kemp JJ, et al. The pattern of symptom change during prolonged exposure therapy and present-centered therapy for PTSD in active duty military personnel. Psychol Med. 2019;49(12):1980-89. doi: https://doi.org/10.1017/S0033291718002714
Presseau C, Litz BT, Kline NK, et al. An epidemiological evaluation of trauma types in a cohort of deployed service members. Psychol Trauma. 2019;11(8):877-85. doi: https://doi.org/10.1037/tra0000465
Mediavilla R, Felez-Nobrega M, McGreevy KR, et al. Effectiveness of a mental health stepped-care programme for healthcare workers with psychological distress in crisis settings: a multicentre randomised controlled trial. BMJ Ment Health. 2023;26(1):e300697. doi: https://doi.org/10.1136/bmjment-2023-300697
Rija A, Islam Z, Bilal W, et al. The impact of violence on healthcare workers' mental health in conflict based settings amidst COVID‐19 pandemic, and potential interventions: a narrative review. Health Sci Rep. 2022;5:e920. doi https://doi.org/10.1002/hsr2.920
Kakaje A, al Zohbi R, Hosam Aldeen O, Makki L, Alyousbashi A, Alhaffar MBA. Mental disorder and PTSD in Syria during wartime: anationwide crisis. BMC Psychiatry. 2021;21(1):2. doi: https://doi.org/10.1186/S12888-020-03002-3/FIGURES/2
Marie M, Adeen S, Battat M. Anxiety disorders and PTSD in Palestine: a literature review. BMC Psychiatry. 2020;20(1):509. doi: https://doi.org/10.1186/S12888-020-02911-7
Hamdan M, Hamra AA. Burnout among workers in emergency Departments in Palestinian hospitals: prevalence and associated factors. BMC Health Serv Res. 2017;17(1):407.
doi: https://doi.org/10.1186/S12913-017-2356-343
Elnakib S, Elaraby S, Othman F, et al. Providing care under extremeadversity: the impact of the Yemen conflict on the personal and professional lives of health workers. Soc Sci Med. 2021;272:113751. doi: https://doi.org/10.1016/J.SOCSCIMED.2021.113751
de Lesquen H, Paris R, Fournier M, et al. Toward A Serious Game to Help Future Military Doctors Face Mass Casualty Incidents. J Spec Oper Med. 2023;23(2):88-93. doi: https://doi.org/10.55460/IJCP-BLY6
Elhadi M, Ala Khaled, Malek AB, El-Azhari AE, Gwea AZ, et al. Prevalence of anxiety and depressive symptoms among emergency physicians in Libya after civil war: a crosssectional study. BMJ Open. 2020;10:e039382. doi: https://doi.org/10.1136/bmjopen-2020-039382
Lubin G, Sids C, Vishne T, et al. Acute stress disorder and post-traumatic stress disorder among medical personnel in Judea and Samaria areas in the years 2000–2003. Mil Med. 2007;172:376-8. doi: https://doi.org/10.7205/milmed.172.4.376
Hotopf M, Hull L, Fear NT, et al. The health of UK military personnel who deployed to the 2003 Iraq war: a cohort study. Lancet. 2006;367(9524):1731-41. doi: https://doi.org/10.1016/S0140-6736(06)68662-5
Kolkow TT, Spira JL, Morse JS, Grieger TA. Post-traumatic stress disorder and depression in health care providers returning from deployment to Iraq and Afghanistan. Mil Med. 2007;172:451-5. doi: https://doi.org/10.7205/milmed.172.5.451
Jones M, Fear NT, Greenberg N, Jones N, Hull L, Hotopf M, et al. Do medical services personnel who deployed to the Iraq war have worse mental health than other deployed personnel? Eur J Public Health. 2008;18(4):422-27. doi: https://doi.org/10.1093/eurpub/ckn031
Chargualaf KA, Elliott B. Psychological Effects of Military Service: Applying Research to Civilian & Academic Environments. OJIN: The Online Journal of Issues in Nursing. 2019;24(3). Manuscript 2. doi: https://doi.org/10.3912/OJIN.Vol24No03Man02
Adler AB, Adrian AL, Hemphill M, Scaro NH, Sipos ML, Thomas JL. Professional Stress and Burnout in U.S. Military Medical Personnel Deployed to Afghanistan. Mil Med. 2017;182(3):e1669-e76. doi: https://doi.org/10.7205/MILMED-D-16-00154
Tosone C, Nuttman-Shwartz O, Stephens T. Shared Trauma: When the Professional is Personal. Clin Soc Work J. 2012;40:231-39. doi: https://doi.org/10.1007/s10615-012-0395-0
Tosone C, McTighe JP, Bauwens J. Shared traumatic stress among social workers in the aftermath of Hurricane Katrina. Br J Soc Work. 2015;45(4):1313-29. doi: https://doi.org/10.1093/bjsw/bct194
Freedman SA, Tuval Mashiach R. Correction: Shared trauma reality in war: Mental health therapists' experience. Plos One. 2018;13(3):e0194359. doi: https://doi.org/10.1371/journal.pone.0194359
Jenzer T, Meisel SN, Blayney JA, Colder CR, Read JP. Reciprocal processes in trauma and coping: Bidirectional effects over a four-year period. Psychol Trauma. 2020;12(2):207-18. doi: https://doi.org/10.1037/tra0000500

PDF

Authors and affiliations

Cite

Metrics

CLINICAL MEDICINE

Stupnytskyi M.A., Syroyid M.V., Dumchenko O.I., Denysenko N.V., Fedevych Yu.M. Methabolic reaction on the cerebral ischemia during carotid artery surgery

https://doi.org/10.26641/2307-0404.2023.4.294000

Abstract

References

Wang ZW, Pohorielov OV, Bobokalo SV, Baranenko OM, Chun L. [Effects of dihydroquercetin (DHQ “P” drops) in patients with previous transitory ischemic attacks associated with visual disorders]. Medicni perspektivi.2020;25(4):81-7. doi: https://doi.org/10.26641/2307-0404.2020.4.221234
Kiselyk IO, Lootsyk MD, Shevchenko LYu.[Features of determination of nitrates and nitrites in blood of patients with viral hepatitis and jaundice of other etiology]. Laboratory diagnostics. 2001;3:43-5. Ukrainian.
Syroid MV, Vojtanovsky IM, Martynyuk OI, Malytsky VYe, Maykut VM, Pavchak RM, et al. [Repeated surgery of the extracranial arteries]. Scientific bulletin of Uzhhorod university series medicine. 2020;1(61):93-5. Ukrainian. doi: https://doi.org/10.24144/2415-8127.2020.61.93-95
Syroid MV, Vojtanovsky IM, Tytyuk VA, Malytsky VYe, Pavchak RM. [Peculiarities of separation and reconstruction of carotid arteries at their aterosklerotic lesion]. Scientific bulletin of Uzhhorod university series medicine. 2012;3(45):109-13. Ukrainian.
Abergas ADC, Aleria MCQ, Elio AEM, et al. Comparative Analysis of Arginine Content of Three Commercially Available Baby Formula in the Philippines using Multiple Point Standard Addition Method. International Proceedings of Chemical, Biological and Environmental 2012;49:198-202. doi: https://doi.org/10.7763/IPCBEE.2012.V49.39
Ahmad AS, Shah ZA, Doré S. Protective Role of Arginase II in Cerebral Ischemia and Excitotoxicity. Journal of Neurology and Neuroscience. 2016;7:88. doi: https://doi.org/10.21767/2171-6625.100088
Alnakshbandi AA, Al-Nimer MSM, Alhassani High serum peroxynitrite level is an early effect of chronic cigarette smoking. Saudi Journal for Health Sciences. 2012;1:139-42. doi: https://doi.org/10.4103/2278-0521.106083
Bewick V, Cheek L, Ball J. Statistics review 7: Correlation and regression. Critical Care. 2003;7:451-9. doi: https://doi.org/10.1186/cc2401
Giustarini D, Fanti P, Matteucci E, et al. Micro-method for the determination of glutathione in human blood. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2014;964:191-4. doi: https://doi.org/10.1016/j.jchromb.2014.02.018
Magistretti PJ, Allaman I. Lactate in the brain: From metabolic end-product to signalling molecule. NatureReviews 2018;19:235-49. doi: https://doi.org/10.1038/nrn.2018.19
Menon B, Ramalingam K, Kumar R. Evaluating the Role of Oxidative Stress in Acute Ischemic Stroke. Journal of Neurosciences in Rural Practice. 2020;11:156-9. doi: https://doi.org/10.1055/s-0039-3402675
Sabadashka M, Nagalievska M, Sybirna N. Tyrosine nitration as a key event of signal transduction that regulates functional state of the cell. Cell biology international.2021;45(3):481-97. doi: https://doi.org/10.1002/cbin.11301
Sies H, Jones DP. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nature Reviews Molecular Cell Biology. 2020;21:363-83. doi: https://doi.org/10.1038/s41580-020-0230-3
Weber D, Davies MJ, Grune T. Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions. Redox Biology. 2015;5:367-80. doi: https://doi.org/10.1016/j.redox.2015.06.005
Whitley E, Ball J. Statistics review 6: Nonparametric Critical Care. 2002;6:509-13. doi: https://doi.org/10.1186/cc1820
Won SJ, Kim J, Cittolin-Santos GF, et al. Assessment at the Single-Cell Level Identifies Neuronal Glutathione Depletion As Both a Cause and Effect of Ischemia-Reperfusion Oxidative Stress. Journal of Neuroscience. 2015;35:7143-52. doi: https://doi.org/10.1523/JNEUROSCI.4826-14.2015

PDF

Authors and affiliations

Cite

Metrics

Bielinskyi M.V., Seredyuk N.M., Vytryhovskiy A.I., Koroliuk V.D. Impact of type 2 diabetes mellitus on low-grade inflammation in patients with ST-elevated myocardial infarction

https://doi.org/10.26641/2307-0404.2023.4.294006

Abstract

Chronic low-grade inflammation has emerged as a hallmark of type 2 diabetes mellitus (T2DM), contributing significantly to the pathogenesis of various cardiovascular diseases, notably ST-elevated myocardial infarction (STEMI). The intricate interplay between inflammation and cardiovascular health in the context of T2DM has been a subject of intensive research in recent years. In particular, the development of various markers of inflammation has provided valuable tools for better understanding the complex relationship between low-grade inflammation and cardiovascular disease in T2DM. Elevated levels of these markers have been consistently associated with increased cardiovascular risk in patients with T2DM, indicating their potential as prognostic indicators. The aim of the study was to investigate the potential association between type 2 diabetes mellitus and low-grade inflammation markers in patients with ST-elevated myocardial infarction through a comparative analysis of systemic immune-inflammation indices, fibronectin, and soluble suppression of tumorogenesis-2 (sST2) levels in ST-elevated myocardial infarction patients with and without type 2 diabetes mellitus. We enrolled 158 patients diagnosed with STEMI who were admitted to the Ivano-Frankivsk Regional Clinical Cardiological Center. The study population was divided into three groups: 1 – consisting of 45 patients with both STEMI and T2DM, and the 2 – consisting of 34 patients with STEMI only, T2DM only group – 69 patients, Control group – 10 healthy patients. In summary, the findings from the study provide compelling evidence to support the notion that patients who suffer from both STEM and T2DM exhibit a more robust inflammatory response and higher platelet count, compared to those with STEMI alone. These results suggest that the presence of T2DM may exacerbate the pro-inflammatory and pro-thrombotic state that is typically associated with STEMI, thereby emphasizing the critical need for early intervention to prevent or mitigate inflammation and platelet activation in this particular patient population. Type 2 diabetes mellitus patients with ST-segment elevation myocardial infarction show higher levels of inflammation markers and fibronectin, indicating greater low-grade inflammation. Elevated levels of soluble suppression of tumorigenicity 2 suggest myocardial remodeling. Targeting low-grade inflammation could be a potential therapy for STEMI in T2DM patients.

Key words: myocardial infarction, diabetes mellitus, inflammation, atherosclerosis, ST2, fibronectin

References

Vogel B, Claessen BE, Arnold SV, Chan D, Cohen DJ, Giannitsis E, et al. ST-segment elevation myocardial infarction. Nature Reviews Disease Primers. 2019;5(1):1-20. doi: https://doi.org/10.1038/s41572-019-0090-3
Glovaci D, Fan W, Wong ND. Epidemiology of Diabetes Mellitus and Cardiovascular Disease. Curr Cardiol Rep. 2019;21(4):1-8. doi: https://doi.org/10.1007/S11886-019-1107-Y/METRICS
Rotariu D, Babes EE, Tit DM, Moisi M, Bustea C, Stoicescu M, et al. Oxidative stress – Complex pathological issues concerning the hallmark of cardiovascular and metabolic disorders. Biomedicine & Pharmacotherapy. 2022;152:113238. doi: https://doi.org/10.1016/j.biopha.2022.113238
Sharif S, Van der Graaf Y, Cramer MJ, Kapelle LJ, de Borst GJ, Visseren FLJ, et al. Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes. Cardiovasc Diabetol. 2021;20(1):1-8. doi: https://doi.org/10.1186/S12933-021-01409-0
Castro AM, Macedo-de la Concha LE, Pantoja-Meléndez CA. Low-grade inflammation and its relation to obesity and chronic degenerative diseases. Revista Médica del Hospital General de México. 2017;80(2):101-5. doi: https://doi.org/10.1016/j.hgmx.2016.06.011
Ye Z, Hu T, Wang J, Xiao R, Liao X, Liu M, et al. Systemic immune-inflammation index as a potential biomarker of cardiovascular diseases: A systematic review and meta-analysis. Front Cardiovasc Med. 2022;9:e933913. doi: https://doi.org/10.3389/FCVM.2022.933913
Zarà M, Campodonico J, Cosentino N, Biondi ML, Amadio P, Milanesi G, et al. Plasma exosome profile in st-elevation myocardial infarction patients with and without out-of-hospital cardiac arrest. Int J Mol Sci. 2021;22(15):8065. doi: https://doi.org/10.3390/IJMS22158065/S1
Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevationThe Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-77. doi: https://doi.org/10.1093/EURHEARTJ/EHX393
Davies MJ, Aroda VR, Collins BS, Gabbay RA, Green J, Maruthur NM, et al. Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2022;65(12):1925-66. doi: https://doi.org/10.1007/S00125-022-05787-2
Fan W, Wei C, Liu Y, Sun Q, Tian Y, Wang X, et al. The Prognostic Value of Hematologic Inflammatory Markers in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention. Clinical and Applied Thrombosis/Hemostasis. 2022;28:10760296221146183. doi: https://doi.org/10.1177%2F10760296221146183
Antonov MY, Korobeynikov GV, Khmelnitskaya IV, Kharkovlyuk-Balakina NV. [Mathematical methods of processing and modeling the results of experimental research: a textbook]. Kyiv: Olympic literature; 2021. 216 p. Ukrainian.
Lucci C, Cosentino N, Genovese S, Campodonico J, Milazzo V, De Metrio M, et al. Prognostic impact of admission high-sensitivity C-reactive protein in acute myocardial infarction patients with and without diabetes mellitus. Cardiovascular Diabetology. 2020;19(1):1-3. doi: https://doi.org/10.1186/S12933-020-01157-7
Yang YL, Wu CH, Hsu PF, Chen SC, Huang SS, Chan WL, et al. Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Invest. 2020;50(5):e13230. doi: https://doi.org/10.1111/ECI.13230
Ji Z, Liu G, Guo J, Zhang R, Su Y, Carvalho A, et al. The Neutrophil-to-Lymphocyte Ratio Is an Important Indicator Predicting In-Hospital Death in AMI Patients. Front Cardiovasc Med. 2021;8:1138. doi: https://doi.org/10.3389/fcvm.2021.706852
Tashchuk VK, Bota RA, Salama MA. [Dynamics of leukocyte inflammatory markers in patients with ST-segment elevation myocardial infarction depending on left ventricular ejection fraction]. Pathology. 2022;19(3):195-200. Ukrainian.
doi: https://doi.org/10.14739/2310-1237.2022.3.267268
Çelik MC, Karayiğit O, Ozkan C, Dolu AK, Kalçık M. Relationship Between Systemic Inflammation Index and No-Reflow Phenomenon in Patients With ST-Segment Elevation Myocardial Infarction. Angiology. 2023;74(4):387-94. doi: https://doi.org/10.1177/00033197221115562
Kayama Y, Raaz U, Jagger A, Adam M, Schellinger IN, Sakamoto M, et al. Diabetic Cardiovascular Disease Induced by Oxidative Stress. Int J Mol Sci. 2015;16(10):25234-63. doi: https://doi.org/10.3390/IJMS161025234
Jha D, Goenka L, Ramamoorthy T, Sharma M, Dhandapani VE, George M. Prognostic role of soluble ST2 in acute coronary syndrome with diabetes. Eur J Clin Invest. 2018;48(9):e12994. doi: https://doi.org/10.1111/ECI.12994
Zhuravlova MI. [The relationship between calprotectin and parameters of lipid and carbohydrate metabolism, anthropometric and inflammatory parameters in patients with acute myocardial infarction and diabetes mellitus type 2]. Current issues of modern medicine. 2019;19(2):16-8. Ukrainian. doi: https://doi.org/10.31718/2077-1096.19.2.16
Hilova YaV. [Biomarker of myocardial stress sST2 in patients with acute myocardial infarction with ST-segment elevation]. Ukrainian Journal of Medicine, Biology and Sports. 2018;3(2):55-9. Ukrainian. doi: https://doi.org/10.26693/jmbs03.02.055
Bilovol OM, Knyazkova II. [Towards the use of biomarkers in special patient subgroups: a focus on soluble ST2]. Medicine of Ukraine. 2022;265-266(9-10):24-8. Ukrainian. doi: https://doi.org/10.37987/1997-9894.2022.9-10(265-6).271848

PDF

Authors and affiliations

Cite

Metrics

Miakinkova L.O., Yarmola T.I., Pustovoit G.L., Kostrikova Iu.A., Pysana B.O., Talash V.V. Рrevention of contrast-induced nephropathy during interventional treatment of acute coronary syndrome

https://doi.org/10.26641/2307-0404.2023.4.294013

Abstract

The aim of the work was to determine the risk factors of contrast-induced nephropathy in patients with acute coronary syndrome and to evaluate the effectiveness of methods of its prevention. There were examined 62 patients admitted to the interventional cardiology department during 9 months of routine practice with a diagnosis of acute coronary syndrome and concomitant chronic kidney disease. Among them, 56.45% have diabetic nephropathy, 21% – hypertensive nephropathy, 19.35% – chronic pyelonephritis, 3.2% – gouty nephropathy. According to the stages of chronic kidney disease: I stage – 8.1%, II stage – 46.8%, III A stage – 30.6%, III B stage – 14.5% of patients. The control group consisted of 32 patients with acute coronary syndrome without kidney pathology. All patients underwent urgent percutaneous coronary intervention with a water-soluble low-osmolarity radiocontrast medium. The risk of contrast-induced nephropathy was determined according to the Mehran scale. Contrast-induced nephropathy was diagnosed by an increase in serum creatinine by >25% over 24-48 hours. Prevention of contrast-induced nephropathy according to existing recommendations was carried out by prescribing early statin therapy and diuresis-controlled combined hydration in 22 patients with concomitant chronic kidney disease. Mathematical processing was performed using Statistica 8.0 software (StatSoft Inc, USA). Patients with chronic kidney disease had a high and very high risk of contrast-induced nephropathy in 19.4% and 3.2% of cases, among them in 91.6% high, and in 100% – very high-risk contrast-induced nephropathy developed. Patients in the control group had a low to moderate risk, none of them developed contrast-induced nephropathy. It has been shown that the risk of contrast-induced nephropathy depends on the stage of chronic kidney disease and is associated with a decrease in the ejection fraction of the left ventricle (≤40%), acute left ventricle failure of the III and IV classes according to Killip, a decrease in diuresis up to ≤0.6 ml/h/kg in the first 12-24 hours after urgent percutaneous coronary intervention; taking metformin 6-12 hours before the administration of the X-ray contrast medium and the glomerular filtration rate ≤45 ml/min./1.73 m². In patients who underwent prevention of contrast-induced nephropathy in its entirety, its development was not registered.

Key words: contrast-induced nephropathy, urgent percutaneous coronary intervention, acute coronary syndrome, chronic kidney disease

References

Chekalina NI. Resveratrol has a positive effect on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease. Wiad Lek. 2017;70(2,2):286-91.
Chekalina NI, Kazakov YM, Mamontova TV, Vesnina LE, Kaidashev IP. Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery disease. Wiad Lek. 2016;69(3,2):475-9.
Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization. EuroIntervention.2019;14(14):1435-534. doi: https://doi.org/10.4244/EIJY19M01_01
Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et. al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-77. doi: https://doi.org/10.1093/eurheartj/ehx393
Shams E, Mayrovitz HN. Contrast-Induced Nephropathy: A Review of Mechanisms and Risks. Cureus. 2021;13(5):e14842. doi: https://doi.org/10.7759/cureus.14842
Yang Y, George KC, Luo R, Cheng Y, Shang W, Ge S, et al. Contrast-induced acute kidney injury and adverse clinical outcomes risk in acute coronary syndrome patients undergoing percutaneous coronary intervention: a meta-analysis. BMC 2018;19(1):374. doi: https://doi.org/10.1186/s12882-018-1161-5
Ivanov D. [Contrast-induced nephropathy: searching for new solutions to prevent its development]. POCHKI. 2021;8(3):136-8. doi: https://doi.org/10.22141/2307-1257.8.3.2019.176450
Aksu U, Gulcu O, Aksakal E, Kalkan K, Topcu S. Long-Term Mortality and Contrast-Induced Nephropathy. Angiology.2019;70(8):783. doi: https://doi.org/10.1177/0003319718823628
Maioli M, Toso A, Gallopin M, Leoncini M, Tedeschi D, Micheletti C, et al. Preprocedural score for risk of contrast-induced nephropathy in elective coronary angiography and intervention. J Cardiovasc Med (Hagerstown). 2010;11(6):444-9. doi: https://doi.org/10.2459/JCM.0b013e328335227c
Macdonald DB, Hurrell C, Costa AF, McInnes MDF, O'Malley ME, Barrett B, et al. Canadian Association of Radiologists Guidance on Contrast Associated Acute Kidney Injury. Can Assoc Radiol J. 2022;73(3):499-514. doi: https://doi.org/10.1177/08465371221083970
Pustovoyt AL, Yarmola TI, Talash VV, Tkachenko LA, Kostrikova UA. [Studying the Main Issues of Contrast-Induced Nephropathy (Review of Literature)]. JMBS.2018;3(2,11):208-16. doi: https://doi.org/10.26693/jmbs03.02.208
Van der Molen AJ, Reimer P, Dekkers IA, Bongartz G, Bellin MF, Bertolotto M, et al. Post-contrast acute kidney injury. P. 2: risk stratification, role of hydration and other prophylactic measures, patients taking metformin and chronic dialysis patients: Recommendations for updated ESUR Contrast Medium Safety Committee guidelines. Eur 2018;28(7):2856-69. doi: https://doi.org/10.1007/s00330-017-5247-4
Steffens L, Hayes L, Wiebe AZ. Pharmacology of Contrast-In- duced Nephropathy. AACN Advanced Critical 2019;30(2):97-104. doi: https://doi.org/10.4037/aacnacc2019550
Mehran R, Owen R, Chiarito M, Baber U, Sartori S, Cao D, et al. A contemporary simple risk score for prediction of contrast-associated acute kidney injury after percutaneous coronary intervention: derivation and validation from an observational registry. Lancet. 2021;398(10315):1974-83. doi: https://doi.org/1016/S0140-6736(21)02326-6
Antomonov MYu. [Mathematical processing and analysis of biomedical data]. Kyiv: Firma maloho druku; 2006. 558 p. Ukrainian.

PDF

Authors and affiliations

Cite

Metrics

Shuprovych A.A., Zinych O.V., Kushnareva N.M., Trofymenko O.M., Komisarenko K.P. Study of the association of polymorphisms of the folate cycle enzyme gene with the degree of cognitive and affective disorders in patients in the post-covid period

https://doi.org/10.26641/2307-0404.2023.4.294019

Abstract

Recently, molecular genetic studies have become widespread, and demonstrated the importance of DNA and histone methylation processes in the epigenetic regulation of gene expression. The aim of this study was to detect the association of polymorphisms of the folate cycle enzyme gene methylenetetrahydrofolate reductase (MTHGFR) with the degree of cognitive and affective disorders and the serum level of homocysteine and folic acid in 41 post-covid patients. Hematological and laboratory indices, serum concentration of C-reactive protein, D-dimer, homocysteine and folic acid were determined. MTHGFR polymorphisms for C677T and A1298C mutations were determined by polymerase chain reaction in real time. According to the MTHGFR C677T genotype variant, the examined patients were divided into 3 groups: 1) 21 persons (male/female 10/11) with homozygous CC genotype; 2) 17 ones (male/female 12/5) with heterozygous CT genotype; 3) 3 persons with a recessive homozygous TT genotype (all men). Six months after the end of the acute phase of the coronavirus disease, patients were surveyed using questionnaires to assess the psycho-emotional state: cognitive function, anxiety and depression. No significant difference was found in the average scores of cognitive function, anxiety and depression in patients of group 1 and 2. Individuals of the group 1 C677C, who had an additional recessive homozygous C1298C mutation (group 1a, n=6), were characterized by an elevated level of homocysteine, which showed a high negative correlation with serum folate (r= -0.95). A small group of individuals with the recessive homozygous T677T genotype (group 3, all men) was distinguished by an older age, the presence of cardiovascular diseases, type 2 diabetes (2 cases out of 3), more severe manifestations of COVID-19, which forces us to pay attention to potentially increased risk of complications in such patients and requires further investigation. Correlation relationships between assessments of cognitive function, anxiety, depression and serum levels of homocysteine and folate in patients with different genotypes of MTHGFR C677T were recorded. Therefore, the use of a molecular genetic approach made it possible to pay attention to the possible predisposition to hyperhomocysteinemia in individuals who have a folic acid deficiency, and different combination of alleles of the MTHGFR gene C677T and A1298C.

Key words: methylenetetrahydrofolate reductase, polymorphism, homocysteine, folic acid, neurocognitive complications, post-covid period

References

Liu F, Chen J, Li Z, Meng X. Recent advances in epigenetics of age-related kidney diseases. Genes. 2022;13(796):1-22. doi: https://doi.org/10.3390/genes13050796
Kern B, Podkrajšek K, Kovač J, Šket R, Bizjan B, et al. The Role of epigenetic modifications in late complications in type 1 diabetes. Genes (Basel). 2022 Apr;13(4):705. doi: https://doi.org/10.3390/genes13040705
Andreichyn M, Nychyk N, Zavidniuk N, Yosyk Ya, Ishchuk I, Ivakhiv O. [COVID-19: epidemiology, clinic, diagnosis, treatment and prevention]. Infektsiini khvoroby. 2020;2(100):41-55. doi: https://doi.org/10.11603/1681-2727.2020.2.11285
Perła-Kaján J, Jakubowski H. COVID-19 and One-Carbon Metabolism. Int J Mol Sci. 2022 Apr;23(8):4181. doi: https://doi.org/10.3390/ijms23084181
Sun J, Jiang X, Zhao M, Ma L, Pei H, Liu N, et al. Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis. Behav 2021;2021:2962792. doi: https://doi.org/10.1155/2021/2962792
Raina JK, Panjaliya RK, Dogra V, Sharma S, Anupriya, Kumar P. Association of МТГФР and MS/MTR gene polymorphisms with congenital heart defects in North Indian population (Jammu and Kashmir): a case-control study encompassing meta-analysis and trial sequential analysis. BMC 2022 Apr 25;22(1):223. doi: https://doi.org/10.1186/s12887-022-03227-z
Ren ZJ, Zhang YP, Ren PW, Yang B, Deng S, Peng ZF, et al. Contribution of MTR A2756G polymorphism and MTRR A66G polymorphism to the risk of idiopathic male infertility. Medicine (Baltimore). 2019 Dec;98(51):e18273. doi: https://doi.org/10.1097/MD.0000000000018273
Ponti G, Pastorino L, Manfredini M, Ozben T, Oliva G, Kaleci S, et al. COVID‐19 spreading across world correlates with C677T allele of the methylenetetrahydrofolate reductase (МТГФР) gene prevalence. J Clin Lab Anal. 2021;35(7):e23798. doi: https://doi.org/10.1002/jcla.23798
Ponti G, Ruini C, Tomasi A. Homocysteine as a potential predictor of cardiovascular risk in patients with COVID‐19. Med Hypotheses. 2020;143:109859. doi: https://doi.org/10.1016/j.mehy.2020.109859
Attademo L, Bernardini F. Are dopamine and serotonin involved in COVID-19 pathophysiology? Eur J Psychiatry. 2021 Jan-Mar;35(1):62-3. doi: https://doi.org/10.1016/j.ejpsy.2020.10.004
Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. Neurological associations of COVID-19. Lancet Neurol. 2020 Sep;19(9):767-83. doi: https://doi.org/10.1016/S1474-4422(20)30221-0
Oros MM,  Opiiari T V,  Nod M M, Mikhalova A. [Analysis of psychoneurological complications and vitamin B12 deficiency caused by COVID-19]. NeiroNEWS. 2021;7(128):37-41.
Periñán MT, Macías-García D, Jesús S, Martín-Rodríguez JF, Muñoz-Delgado L, Jimenez-Jaraba MV, et al. Homocysteine levels, genetic background, and cognitive impairment in Parkinson's disease. J Neurol. 2023 Jan;270(1):477-85. doi: https://doi.org/10.1007/s00415-022-11361-y
Sun J, Jiang X, Zhao M, Ma L, Pei H, Liu N, et al. Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis. Behav 2021 Sep 18;2021:2962792. doi: https://doi.org/10.1155/2021/2962792
Gao J, Xiu MH, Liu DY, Wei CW, Zhang X. Interactive effect of МТГФР C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia. Aging. 2020 Jun 4;12(11):10290-9. doi: https://doi.org/10.18632/aging.103248
Choi EP, Hui BP, Wan EY. Depression and Anxiety in Hong Kong during COVID-19. Int J Environ Res Public Health. 2020 May 25;17(10):3740. doi: https://doi.org/10.3390/ijerph17103740
Mazza MG, De Lorenzo R, Conte C, Poletti S, Vai B, Bollettini I, et al. COVID-19 BioB Outpatient Clinic Study group, Benedetti F. Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors. Brain Behav Immun. 2020 Oct;89:594-600. doi: https://doi.org/10.1016/j.bbi.2020.07.037
You M, Zhou X, Yin W, et al. The Influence of MTHFR Polymorphism on Gray Matter Volume in Patients With Amnestic Mild Cognitive Impairment. Front Neurosci.2021;15:778123. doi: https://doi.org/10.3389/fnins.2021.778123
Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale, HADS. Acta Psych Scand. 1983;67(6):361-70.
doi: https://doi.org/10.1111/j.1600-0447.1983.tb09716.x
Brodaty H, Pond D, Kemp NM, Luscombe G, Harding L, Berman K, et al. The General Practitioner assessment of Cognition, GPCOG: a new screening test for dementia designed for general practice. J Am Geriatr Soc. 2002 Mar;50(3):530-4. doi: https://doi.org/10.1046/j.1532-5415.2002.50122.x
Antomonov MY. [Mathematical processing and analysis of medical and biological data]. 2nd ed. Kyiv: Medinform; 2017. 578 p. Russian.
Jaraba MV, Buiza-Rueda D, Bonilla-Toribio M, Adarmes-Gómez AD, Gómez-Garre P, Mir P. Homocysteine levels, genetic background, and cognitive impairment in Parkinson's disease. J Neurol. 2023 Jan;270(1):477-85. doi: https://doi.org/10.1007/s00415-022-11361-y
Zhang YX, Yang LP, Gai C, Cheng CC, Guo ZY, Sun HM, et al. Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis. Front Psychiatry.2022 Aug 18;13:976428. doi: https://doi.org/10.3389/fpsyt.2022.976428
Gogu AE, Jianu DC, Dumitrascu V, Ples H, Stroe AZ, et al. MTHFR Gene Polymorphisms and Cardiovascular Risk Factors, Clinical-Imagistic Features and Outcome in Cerebral Venous Sinus Thrombosis. Brain Sci. 2020 Dec 27;11(1):23. doi: https://doi.org/10.3390/brainsci11010023
Meng X, Zheng JL, Sun ML, Lai HY, Wang BJ, Yao J, et al. Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis. PLoS One. 2022 Jul 14;17(7):e0271170. doi: https://doi.org/10.1371/journal.pone.0271170
Lopes MJ. Can vitamin B12 be an adjuvant to COVID-19 treatment? GSC Biol Pharmac Sciences. 2020;11(3):01-05. doi: https://doi.org/10.30574/gscbps.2020.11.3.0155
van der Made CI, Simons A, Schuurs-Hoeijmakers J, van den Heuvel G, Mantere T, Kersten S, et al. Presence of genetic variants among young men with severe COVID-19. JAMA. 2020;324(7):663-73. doi: https://doi.org/10.1001/jama.2020.13719

PDF

Authors and affiliations

Cite

Metrics

Kuryata O.V., Frolova Ye.O., Stadnyk O.I., Semenov V.V. COVID-19 and arterial hypertension: whether normal blood pressure is a sign of a benign course of COVID-19

https://doi.org/10.26641/2307-0404.2023.4.294029

Abstract

References

Gallo G, Calvez V, Savoia C. Hypertension and COVID-19: Current Evidence and Perspectives. High Blood Press Cardiovasc Prev. 2022 Mar;29(2):115-23. doi: https://doi.org/10.1007/s40292-022-00506-9
Cannatà A, Bromage DI, McDonagh TA. The collateral cardiovascular damage of COVID-19: only history will reveal the depth of the iceberg. Eur Heart J. 2021 Apr 14;42(15):1524-7. doi: https://doi.org/10.1093/eurheartj/ehab097
Holt A, Gislason GH, Schou M, Zareini B, Biering-Sørensen T, Phelps M, et al. New-onset atrial fibrillation: incidence, characteristics, and related events following a national COVID-19 lockdown of 5.6 million people. Eur Heart J. 2020 Jun 1;41(32):3072-9. doi: https://doi.org/10.1093/eurheartj/ehaa494
Farshidfar F, Koleini N, Ardehali H. Cardiovascular complications of COVID-19. JCI Insight. 2021;6(13):148980. doi: https://doi.org/10.1172/jci.insight.148980
Task Force for the management of COVID-19 of the European Society of Cardiology. ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 2-care pathways, treatment, and follow-up. Eur Heart J. 2022 Mar 14;43(11):1059-103. doi: https://doi.org/10.1093/eurheartj/ehab697
Monaghesh E, Hajizadeh A. The role of telehealth during COVID-19 outbreak: a systematic review based on current evidence. BMC Public Health. 2020 Aug 1;20:1193. doi: https://doi.org/10.1186/s12889-020-09301-4
Kagiyama N, Hiki M, Matsue Y, Dohi T, Matsuzawa W, Daida H, et al. Validation of telemedicine-based self-assessment of vital signs for patients with COVID-19: A pilot study. J Telemed Telecare. 2021 Sep 29;29(8);600-6. doi: https://doi.org/10.1177/1357633X211011825
[Organization of medical assistance for patients with the coronavirus disease (COVID-19). Order of the Ministry of Health of Ukraine dated 2020 Mar 28, No. 722]. [Internet]. 2020 [cited 2022 Sep 27]. Ukrainian. Available from: https://zakon.rada.gov.ua/go/v0722282-20
[On the approval of the protocol "Providing medical assistance for the treatment of the coronavirus disease (COVID-19)". Order of the Ministry of Health of Ukraine dated 2020 Apr 2, No. 762]. [Internet]. 2020 [cited 2022 Sep 27]. Ukrainian. Available from: https://zakon.rada.gov.ua/go/v0762282-20
Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018 Sep 1;39(33):3021-104. doi: https://doi.org/10.1093/eurheartj/ehy339
Messiah S. Body Mass Index. In: Gellman MD, Turner JR, editors. Encyclopedia of Behavioral Medicine. [Internet]. New York, NY: Springer; 2013 [cited 2023 Sep 13]:247-9. doi: https://doi.org/10.1007/978-1-4419-1005-9_729
Eknoyan G, Lameire N, Echardt K, et al. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl. 2013;3(1):1-150. doi: https://doi.org/10.1038/kisup.2012.74
R Core Team. R: A language and environment for statistical computing [Internet]. Vienna, Austria: R Foundation for Statistical Computing, Vienna, Austria; 2022 [cited 2023 Sep 13]. Available from:
https://www.R-project.org/
Petrie A, Sabin C. Medical statistics at a glance. 4^thHoboken, NJ: Wiley-Blackwell; 2019. doi: https://doi.org/10.33029/9704-5904-1-2021-NMS-1-232
Raimondi F, Novelli L, Ghirardi A, Russo FM, Pellegrini D, et al. Covid-19 and gender: lower rate but same mortality of severe disease in women – an observational study. BMC Pulm Med. 2021 Mar 20;21(1):96. doi: https://doi.org/10.1186/s12890-021-01455-0
Vulturar DM, Crivii CB, Orăsan OH, Palade E, Buzoianu AD, Zehan IG, et al. Obesity Impact on SARS-CoV-2 Infection: Pros and Cons “Obesity Paradox”—A Systematic Review. J Clin Med. 2022 Jul 2;11(13):3844. doi: https://doi.org/10.3390/jcm11133844
Ivanov DD, Kuriata OV, Harmish IP. [Blockers of the renin-angiotensin-aldosterone system: chronic kidney disease and cardiovascular risk]. Nyrky. 2018;7(2):81-90. Ukrainian.
doi: https://doi.org/10.22141/2307-1257.7.2.2018.127393
Meijers B, Hilbrands LB. The clinical characteristics of coronavirus-associated nephropathy. Nephrol Dial Transplant. 2020 Aug;35(8):1279-81. doi: https://doi.org/10.1093/ndt/gfaa197
Ahmadian E, Hosseiniyan Khatibi SM, Razi Soofiyani S, Abediazar S, Shoja MM, Ardalan M, et al. Covid-19 and kidney injury: Pathophysiology and molecular mechanisms. Rev Med Virol. 2021;31(3):e2176. doi: https://doi.org/10.1002/rmv.2176
Portolés J, Marques M, López-Sánchez P, de Valdenebro M, Muñez E, Serrano ML, et al. Chronic kidney disease and acute kidney injury in the COVID-19 Spanish outbreak. Nephrol Dial Transplant. 2020 Aug;35(8):1353-61. doi: https://doi.org/10.1093/ndt/gfaa189

PDF

Authors and affiliations

Cite

Metrics

Zbitnieva V.O., Voloshyna O.B., Balashova I.V., Zubok E.A., Dukova O.R., Kovalchuk L.I. Peculiarities of ambulatory blood pressure monitoring in patients who have suffered from COVID-19

https://doi.org/10.26641/2307-0404.2023.4.294034

Abstract

Violations of blood pressure control in patients who have had COVID-19 can be due to many pathophysiological factors. Further study of the features of blood pressure (BP) fluctuations in this category of patients will allow to diagnose arterial hypertension (AH) on time, to identify the uncontrolled course of AH and to select the optimal tactics of patients’ management. It was suggested to determine the characteristics of BP fluctuations in patients who have suffered from COVID-19 more than 12 weeks ago, based on the results of ambulatory (daily) blood pressure monitoring. 98 patients (51 men – 52.0%, 47 women – 47.9%) who have had COVID-19 infection more than 12 weeks ago were examined. Patients were divided into 2 groups – with and without a history of AH. The groups of examinees were homogeneous in age and gender. Ambulatory blood pressure monitoring (AM BP) was carried out on the CardioTens apparatus (Meditech, Hungary) according to the standard method. According to the data of AM BP in patients with AH in the anamnesis, who have suffered from COVID-19 more than 12 weeks ago, significantly higher average indicators of daily systolic blood pressure were recorded, and significant violations of the indicators of variability of systolic blood pressure during the day and night periods, pressure load during the day period, as well as a significantly higher degree and the rate of the morning rise in systolic blood pressure. In patients without a history of AH who have suffered from COVID-19 more than 12 weeks ago, in 21.4% cases there was newly diagnosed AH, in 33.3% of cases, increased variability of systolic blood pressure was observed, mainly during the day, in 21.4% of cases, the degree and speed of the morning rise of systolic blood pressure were increased, which indicated the presence of hypertensive reactions to household loads. In patients with a history of AH, in 55.3% of cases there was observed an increase in average blood pressure values per day, during the day and night periods, which was considered as ineffective blood pressure control and required an increase in the doses of previously prescribed antihypertensive drugs or the use of additional antihypertensive drugs in the treatment regimen. In patients with AH in the anamnesis, who have suffered from COVID-19 more than 12 weeks ago, reliable violations of many indicators of AM BP, deterioration of blood pressure control were recorded. In the patients, who did not have AH and who have suffered from COVID-19 more than 12 weeks ago, the presence of a hypertensive reaction to household loads and newly diagnosed AH were odserved.

Key words: ambulatory (daily) blood pressure monitoring, COVID-19, arterial hypertension

References

Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA cardiology. 2020;5(7):831-40. doi: https://doi.org/10.1001/jamacardio.2020.1286
Zhao M, Wang M, Zhang J, Ye J, Xu Y, et al. Advances in the relationship between coronavirus infection and cardiovascular diseases. Biomedicine & pharmacotherapy= = Biomedecine & pharmacotherapie. 2020;127:110230. doi: https://doi.org/10.1016/j.biopha.2020.110230
Bansal M. Cardiovascular disease and COVID-19. Diabetes & metabolic syndrome. 2020;14(3):247-50. doi: https://doi.org/10.1016/j.dsx.2020.03.013
Zhang D, Shen X, Qi X. Resting heart rate and all-cause and cardiovascular mortality in the general population: a meta-analysis. CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne. 2016;188(3):E53-E63. doi: https://doi.org/10.1503/cmaj.150535
Dhakal BP, Sweitzer NK, Indik JH, Acharya D, William P. SARS-CoV-2 Infection and Cardiovascular Disease: COVID-19 Heart. Heart Lung Circ. 2020;29(7):973-87. doi: https://doi.org/10.1016/j.hlc.2020.05.101
Guan W, Ni Z, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-20. doi: https://doi.org/10.1056/NEJMoa2002032
Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, et al. Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19). JAMA cardiology. 2020;5(7):811-8. doi: https://doi.org/10.1001/jamacardio.2020.1017
Desai AD, Boursiquot BC, Melki L, Wan EY. Management of Arrhythmias Associated with COVID-19. Current cardiology reports. 2021;23(2):1-9. doi: https://doi.org/10.1007/s11886-020-01434-7
Buheruk VV, Vоlоshyna OB, Balashova IV. [Inflammatory damage to the myocardium in patients withnovel coronavirus disease (COVID-19)]. Zaporozhye medical journal. 2021;23(4):555-66. Ukrainian. doi: https://doi.org/10.14739/2310-1210.2021.4.211033
Zbitneva VO, Voloshyna OB, Balashova IV, Dukova OR, Lysiy IS. [Incidence of cardiac arrhythmias in patients with COVID-19 infectionaccording to 24-hour electrocardiogram monitoring]. Zaporizhia Medical Journal. 2021;6(129):759-65. Ukrainian. doi: https://doi.org/10.14739/2310-1210.2021.6.239243
Bryan Williams and others, 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). European Heart Journal. 2018;39(33):3021-104. doi: https://doi.org/10.1093/eurheartj/ehy339
Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D, et al. 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension. 2020;75(6):1334-57. doi: https://doi.org/10.1161/HYPERTENSIONAHA.120.15026
Voloshyna OB, Zbitneva VO, Zubok EA, Balashova IV, Lysyy IS, Dukova OR, et al. [Peculiarities course of arterial hypertension in patients with accompanying diabetes in the post-covid period]. Lviv Clinical Bulletin. 2022;1(37)-2(38):75-80. Ukrainian. doi: https://doi.org/10.25040/lkv2022.01-02.075
Angeli F, Reboldi G, Spanevello A, De Ponti R, Visca D, Marazzato J, et al. Electrocardiographic features of patients with COVID-19: One year of unexpected manifestations. Eur J Intern Med. 2022;95:7-12. doi: https://doi.org/10.1016/j.ejim.2021.10.006
Task Force for the management of COVID-19 of the European Society of Cardiology. European Society of Cardiology guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 1-epidemiology, pathophysiology, and diagnosis. Cardiovasc Res. 2022;118(6):1385-412. doi: https://doi.org/10.1093/cvr/cvab342
Task Force for the management of COVID-19 of the European Society of Cardiology. ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 2-care pathways, treatment, and follow-up. Eur Heart J. 2022;43(11):1059-103. doi: https://doi.org/10.1093/eurheartj/ehab697
Antomonov MYu. [Mathematical processing and analysis of medical and biological data]. 2nd edition. Kiev: Medinform; 2018. 579 p. Russian.

PDF

Authors and affiliations

Cite

Metrics

Molchanov R.M., Honcharuk O.O., Khareba G.G., Blyuss O.B., Duka R.V. Segmental ischemia and indocyanine green navigation: impact on perioperative parameters in laparoscopic vs. open partial nephrectomy

https://doi.org/10.26641/2307-0404.2023.4.294040

Abstract

References

Pallagani L, Choudhary GR, Pandey H, Madduri VKS, Singh M, Gupta P, et al. Epidemiology and Clinicopathological Profile of Renal Cell Carcinoma: A Review from Tertiary Care Referral Centre. Journal of Kidney Cancer and VHL. 2021;8(1):1-6. doi: https://doi.org/10.15586/jkcvhl.v8i1.154
Ljungberg B, Albiges L, Abu-Ghanem Y, et al. European Association of Urology Guidelines on Renal Cell Carcinoma: The 2022 Update. Eur Urol. 2022;82(4):399-410. doi: https://doi.org/10.1016/j.eururo.2022.03.006
Zhang Y, Ellinger J. Clinical studies applying cytokine-induced killer cells for the treatment of renal cell carcinoma. Cancers.2020;12(9):2471. doi: https://doi.org/10.3390/cancers12092471
Fetahu A, Cuni X, Haxhiu I, Cuni L, Manxhuka S, Shahini L. Open Nephron Sparing Surgery for T1a Renal Tumors: Clinical Experience in an Emerging Country. Gulf J Oncolog. 2019;1(31):60-5. PMID: 31591992
Bray G, Bahadori A, Mao D, Ranasinghe S, Tracey C. Benefits of Robotic Assisted vs. Traditional Laparoscopic Partial Nephrectomy: A Single Surgeon Comparative Study. Journal of Clinical Medicine. 2022;11(23):6974. doi: https://doi.org/10.3390/jcm11236974
O'Connor E, Timm B, Lawrentschuk N, Ischia J. Open partial nephrectomy: current review. Transl Androl Urol.2020;9(6):3149-59. doi: https://doi.org/10.21037/tau-20-474
Yu Y, Wang W, Xiong Z, et al. Comparison of Perioperative Outcomes Between Laparoscopic and Open Partial Nephrectomy for Different Complexity Renal Cell Carcinoma Based on the R.E.N.A.L. Nephrometry Score. CancerManag 2021;13:7455-61. doi: https://doi.org/10.2147/CMAR.S324457
Campbell SC, Uzzo RG, Karam JA, et al. Renal Mass and Localized Renal Cancer: Evaluation, Management, and Follow-up: AUA Guideline: Part II. J Urol. 2021;206(2):209-18. doi: https://doi.org/10.1097/JU.0000000000001912
Antonelli A, Minervini A, Sandri M, et al. Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts: Assessing the Relationship between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma. Eur Urol. 2018;74(5):661-7. doi: https://doi.org/10.1016/j.eururo.2018.07.029
Ishiyama Y, Kondo T, Tachibana H, Yoshida K, Takagi T, Iizuka J, et al. Limited impact of warm ischemic threshold for partial nephrectomy in the robotic surgery era: A propensity score matching study. International Journal of Urology. 2021;28(12):1219-25. doi: https://doi.org/10.1111/iju.14674
Basatac C, Akpinar H. ‘Trifecta’ outcomes of robot-assisted partial nephrectomy: Results of the ‘low volume’ surgeon. Int Braz J Urol. 2020;46(6):943-9. doi: https://doi.org/10.1590/s1677-5538.ibju.2019.0396
Gandi C, Totaro A, Bientinesi R, et al. Purely Off-Clamp Partial Nephrectomy: Robotic Approach Better than Open Using a Pentafecta Outcome with Propensity Score Matching. J Clin Med. 2022;11(21):6241. doi: https://doi.org/10.3390/jcm11216241
Wang R, Tang J, Chen Y, Fang Z, Shen J. The clinical value of indocyanine green fluorescence navigation system for laparoscopic partial nephrectomy in the case of complex renal clear cell carcinoma (R.E.N.A.L score>/=7). J Cancer. 2021;12(6):1764-9. doi: https://doi.org/10.7150/jca.55033
Borrego Utiel FJ, Ramirez Navarro AM, Esteban de la Rosa R, Bravo Soto JA. Comparison of MDRD and the old CKD-EPI equations with the new CKD-EPI equations in kidney transplant patients when glomerular filtration rate is measured with 51Cr-EDTA. Nefrologia. 2020;40(1):53-64. doi: https://doi.org/10.1016/j.nefro.2019.07.006
Dindo D, Demartines N, Clavien PA. Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann. Surg. 2004;240(2):205-13. doi: https://doi.org/10.1097/01.sla.0000133083.54934.ae
Kartal I, Karakoyunlu N, Cakici MC, Karabacak O, Sagnak L, Ersoy H. Oncological and functional outcomes of open versus laparoscopic partial nephrectomy in T1b tumors: A single-center analysis. Int Braz J Urol. 2020;46(3):341-50.
doi: https://doi.org/10.1590/S1677-5538.IBJU.2018.0865
Diana P, Buffi NM, Lughezzani G, Dell’Oglio P, Mazzone E, Porter J, et al. The Role of Intraoperative Indocyanine Green in Robot-assisted Partial Nephrectomy: Results from a Large, Multi-institutional Series. European Urology. 2020;78(5):743-9. doi: https://doi.org/10.1016/j.eururo.2020.05.040
Hinata N, Shiroki R, Tanabe K, Eto M, Takenaka A, Kawakita M, et al. Robot-assisted partial nephrectomy versus standard laparoscopic partial nephrectomy for renal hilar tumor: A prospective multi-institutional study. Int J Urol. 2021;28(4):382-9. doi: https://doi.org/10.1111/iju.14469
Garg H, Tiwari D, Nayak B, et al. A comparative analysis of various surgical approaches of nephron-sparing surgery and correlation of histopathological grade with RENAL nephrometry score in renal cell carcinoma. J Minim Access Surg. 2020;16(2):144-51. doi: https://doi.org/10.4103/jmas.JMAS_208_18
Gill IS, Patil MB, et al. Zero ischemia anatomical partial nephrectomy: a novel approach. J Urol. 2012;187(3):807-14. doi: https://doi.org/10.1016/j.juro.2011.10.146
Qian J, Jiang J, Li P, Zhang S, et al. Factors Influencing the Feasibility of Segmental Artery Clamping During Retroperitoneal Laparoscopic Partial Nephrectomy. Urology. 2019;129:92-7. doi: https://doi.org/10.1016/j.urology.2019.03.024
Ruiz Guerrero E, Claro AVO, Ledo Cepero MJ, Soto Delgado M, Álvarez-Ossorio Fernández JL. Robotic versus Laparoscopic Partial Nephrectomy in the New Era: Systematic Review. Cancers. 2023;15(6):1793. doi: https://doi.org/10.3390/cancers15061793
Boga MS, Sönmez MG. Long-term renal function following zero ischemia partial nephrectomy. Research and Reports in Urology. 2019;11:43-52. doi: https://doi.org/10.2147/RRU.S174996
Gadus L, Kocarek J, Chmelik F, Matejkova M, Heracek J. Robotic Partial Nephrectomy with Indocyanine Green Fluorescence Navigation. Contrast Media & Mol Imaging. 2020;2020:1287530. doi: https://doi.org/10.1155/2020/1287530
Cignoli D, Fallara G, Re C, Cei F, Musso G, Basile G, et al. Influences of Age and Comorbidities on Indication for Partial Nephrectomy: A Systematic Review. Kidney Cancer. 2023;7(1):49-65. doi: https://doi.org/10.3233/KCA-230001
Kirkwood BR, Sterne JAC. Essential Medical Statistics. 2nd Edition. Blackwell Science, Oxford; 2003. р. 420-1.
Gandi C, Totaro A, Bientinesi R, Marino F, Pierconti F, Russo A, et al. Purely Off-Clamp Partial Nephrectomy: Robotic Approach Better than Open Using a Pentafecta Outcome with Propensity Score Matching. Journal of Clinical Medicine. 2022 Jan;11(21):6241. doi: https://doi.org/10.3390/jcm11216241

PDF

Authors and affiliations

Cite

Metrics

Averin D.I., Zavizion V.F. Metformin as an adjuvant option for systemic treatment of breast cancer

https://doi.org/10.26641/2307-0404.2023.4.294154

Abstract

The modification of the used and development of new treatment regimens significantly improved the overall, recurrence-free survival and quality of life of patients with malignant oncological diseases. Recently, drugs used in non-oncological pathology have been introduced into cancer treatment regimens. This phenomenon is associated with a better understanding of the biology of tumor cells and the mutations that can change this biology. Metformin is actively researched in terms of the treatment of various oncological diseases. For the most part, the modification of the neoadjuvant treatment regimen for early or locally advanced stages of breast cancer results in a less traumatic variant of surgical procedure, thereby increasing recurrence-free survival. The aim is to systematize the data on the possibilities of the antitumor metformin usage for neoadjuvant treatment of breast cancer and to study the results of clinical and morphological effectiveness of the treatment by reviewing the literature. A search of PubMed from February 2023 showed 258 results on the antitumor effects of metformin, of which only 159 were published in the last 5 years. On this subject only four clinical studies were carried out, and only one of them pertained to the implementation of metformin in the systemic treatment of breast cancer. For this review, 55 sources of general and specialized information on anticancer effects of metformin were analyzed. It should be noted that approximately 60% of the study results were published more than 5 years ago and primarily focused on the biological, not clinical aspects of metformin usage. Only one study regarding the implementation of metformin for systemic treatment of breast cancer was carried out by Ukrainian scientists. Currently, there are 2 main hypotheses regarding the antitumor effect of metformin. First one is driven by its impact on the metabolic function of cells and energy deficit. Second – the method of regulating the proliferation of tumor cells involves the PIK3 branch of the regulatory cascade of biological reactions in cancer cells. In addition, metformin reduces the development of resistance in breast cancer cells, thus allowing active chemotherapy agents to act in synergism. However, further studies on the effect of metformin used alone or in combination with standard chemotherapy regimens require a more adequate definition of proto-oncogenic mutations and somatic mutation load. However, it should be considered that more aggressive therapy of oncological diseases can be a nosocomial selector of more aggressive clones of the pool of tumor cells. The main questions are whether metformin can be a targeted drug for the treatment of tumor, whether it is appropriate to use it at the time when the manifestation of evolution disturbances of tumor cell is minimal and homogeneity is maximal.

Key words: breast cancer, chemotherapy, metformin, modification, neoadjuvant treatment, luminal type, medical resistance, survive of patient

References

Chen YC, Li H, Wang J. Mechanisms of metformin inhibiting cancer invasion and migration. Am J Transl Res. 2020 Sep 15;12(9):4885-901. PMID: 33042396; PMCID: PMC7540116.
Zhu B, Qu S. The Relationship Between Diabetes Mellitus and Cancers and Its Underlying Mechanisms. Front Endocrinol (Lausanne). 2022 Feb 11;13:800995. doi: https://doi.org/10.3389/fendo.2022.800995
Shahid RK, Ahmed S, Le D, Yadav S. Diabetes and Cancer: Risk, Challenges, Management and Outcomes. Cancers (Basel). 2021 Nov 16;13(22):5735. doi: https://doi.org/10.3390/cancers13225735
Global Burden of Disease Collaborative Network, Global Burden of Disease Study 2019 (GBD 2019). Results (2020, Institute for Health Metrics and Evaluation – IHME). [Internet]. [cited 2022 Nov 20]. Available from: https://vizhub.healthdata.org/gbd-results/.14.02.2023
Jing C, Wang Z, Fu X. Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis. BMC Cancer. 2020;20:689.
doi: https://doi.org/10.1186/s12885-020-07139-y
NCCN Breast cancer Evidence Blocks. Version 4/2022 [Internet]. 2022 [cited 2022 Nov 20]. Available from: https://www.nccn.org/professionals/physician_gls/pdf/breast_blocks.pdf
Spring LM, Fell G, Arfe A, et al. Pathologic Complete Response after Neoadjuvant Chemotherapy and Impact on Breast Cancer Recurrence and Survival: A Comprehensive Meta-analysis. Clin Cancer Res. 2020 Jun 15;26(12):2838-48. doi: https://doi.org/10.1158/1078-0432.CCR-19-3492
El-Khayat SM, Abouegylah M, Abdallah D, et al. The effect of metformin when combined with neoadjuvant chemotherapy in breast cancer patients. Med Oncol. 2021 Nov 5;39(1):1.
doi: https://doi.org/10.1007/s12032-021-01599-3
Rapoport BL, Barnard-Tidy J, Van Eeden RI, et al. Pathological complete response in early breast cancer patients undergoing neoadjuvant chemotherapy: Focus on Ki-67 and molecular subtypes. Annals of Oncology. 2019;30(Suppl 3):III37. doi: https://doi.org/10.1093/annonc/mdz097.012
Earl H, Hiller L, Vallier AL, Loi S, McAdam K, Hughes-Davies L, et al. Six versus 12 months' adjuvant trastuzumab in patients with HER2-positive early breast cancer: the PERSEPHONE non-inferiority RCT. Health Technol Assess. 2020 Aug;24(40):1-190. doi: https://doi.org/10.3310/hta24400
Loibl S, Sikov W, Huober J, et al. Event-free survival (EFS), overall survival (OS), and safety of adding veliparib (V) plus carboplatin (Cb) or carboplatin alone to neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) after ≥4 years of follow-up: BrighTNess, a randomized phase III trial. Annals of Oncology. 2021;32(Suppl 5):S407-46. doi: https://doi.org/10.1016/annonc/annonc687
Loibl S, O’Shaughnessy J, Untch M, et al. Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess): A randomised, phase 3 trial. Lancet Oncol. 2018;19(4):497-509. doi: https://doi.org/10.1016/S1470-2045(18)30111-6
Miglietta F, Dieci MV, Tsvetkova V, et al. Validation of Residual Proliferative Cancer Burden as a Predictor of Long-Term Outcome Following Neoadjuvant Chemotherapy in Patients with Hormone Receptor-Positive/Human Epidermal Growth Receptor 2-Negative Breast Cancer. Oncologist. 2020 Sep;25(9):e1355-62. doi: https://doi.org/10.1634/theoncologist.2020-0201
Abe K, Yamamoto N, Hayashi K, et al. Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo. BMC Cancer. 2019;19:689.
doi: https://doi.org/10.1186/s12885-019-5891-y
Fang M, Wang D, Coresh J, Selvin E. Undiagnosed Diabetes in U.S. Adults: Prevalence and Trends. Diabetes Care. 2022 Sep 1;45(9):1994-2002. doi: https://doi.org/10.2337/dc22-0242
Ugwueze CV, Ogamba OJ, Young EE, Onyenekwe BM, Ezeokpo BC. Metformin: A Possible Option in Cancer Chemotherapy. Anal Cell Pathol (Amst). 2020 Apr 27;2020:7180923. doi: https://doi.org/10.1155/2020/7180923
Garcı ́a-Este ́vez L, Corte ́sJ, Pe ́rez S, et al. Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status. Front Oncol. 2021;11:705911. doi: https://doi.org/10.3389/fonc.2021.705911
Viollet B, Horman S, Leclerc J, et al. AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol. 2010;45(4):276-95. doi: https://doi.org/10.3109/10409238.2010.488215
Jalving M, Gietema JA, Lefrandt JD, de Jong S, Reyners AK, Gans ROB, et al. EGE 'Metformin: Taking away the candy for cancer?' Eur J of Cancer. 2010;46(13):2369-80. doi: https://doi.org/10.1016/j.ejca.2010.06.012
Lebelo MT, Joubert AM, Visagie MH. Warburg effect and its role in tumourigenesis. Arch Pharm Res. 2019 Oct;42(10):833-47. doi: https://doi.org/10.1007/s12272-019-01185-2
Yamaguchi R, Perkins G. Challenges in targeting cancer metabolism for cancer therapy. EMBO Rep. 2012;13:1034-5. doi: https://doi.org/10.1038/embor.2012.176
Stine ZE, Schug ZT, Salvino JM, et al. Targeting cancer metabolism in the era of precision oncology. Nat Rev Drug Discov. 2022;21:141-62. doi: https://doi.org/10.1038/s41573-021-00339-6
Saini N, Yang X. Metformin as an anti-cancer agent: Actions and mechanisms targeting cancer stem cells. Acta Biochimica et Biophysica Sinica. 2018;50(2):133-43. doi: https://doi.org/10.1093/abbs/gmx106
Wang Y, An H, Liu T, Qin C, Sesaki H, Guo S, et al. Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK. Cell Rep. 2019 Nov 5;29(6):1511-23.e5. doi: https://doi.org/10.1016/j.celrep.2019.09.070
Hozumi K, Sugawara K, Ishihara T, et al. Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes. Sci Rep. 2023;13:746. doi: https://doi.org/10.1038/s41598-023-27689-y
Sen S, He Y, Koya D, Kanasaki K. Cancer biology in diabetes. J of Diabetes Investigation. 2014;5(3):251-64. doi: https://doi.org/10.1111/jdi.12208
Hsu, Sheng-Kai, Kai-Chun Cheng, et al. New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway. International Journal of Molecular Sciences. 2021;22(17):9453. doi: https://doi.org/10.3390/ijms22179453
Shi B, Hu X, He H, Fang W. Metformin suppresses breast cancer growth via inhibition of cyclooxygenase 2. Oncology Letters. 2021;22(2):615. doi: https://doi.org/10.3892/ol.2021.12876
Bao B, Azmi AS, Ali S, Zaiem F, Sarkar FH. Metformin may function as anti-cancer agent via targeting cancer stem cells: The potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers. Ann Transl Med. 2014;2(6):59. doi: https://doi.org/10.3978/j.issn.2305-5839.2014.06.05
Galliote MM, Tamura RE, Sanchez Rubio IG. Metformin and Cancer Hallmarks: Molecular Mechanisms in Thyroid, Prostate and Head and Neck Cancer Models. Biomolecules. 2022;12(3):357. doi: https://doi.org/10.3390/biom12030357
De A, Kuppusamy G. Metformin in breast cancer: preclinical and clinical evidence. Curr Probl Cancer. 2020 Feb;44(1):100488. doi: https://doi.org/10.1016/j.currproblcancer.2019.06.003
Amjad S, Nisar S, Bhat AA, Shah AR, Frenneaux MP, et al. Role of NAD+ in regulating cellular and metabolic signaling pathways. Mol Metab. 2021;49:101195. doi: https://doi.org/10.1016/j.molmet.2021.101195
Wardhani BW, Puteri MU, Watanabe Y, Louisa M, Setiabudy R, Kato M. TGF-β-Induced TMEPAI Attenuates the Response of Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel. J Exp Pharmacol. 2020 Jan 23;12:17-26. doi: https://doi.org/10.2147/JEP.S235233
Dolhyi V, Avierin D, Hojouj M, Bondarenko I. Tubulin Role in Cancer Development and Treatment. Asp Biomed Clin Case Rep. 2019 Sept 5;2(2):15-22. doi: https://doi.org/10.36502/2019/ASJBCCR.6154
Menendez A, Oliveras-Ferraros C, Cufí S, et al. Metformin is synthetically lethal with glucose withdrawal in cancer cells. Cell Cycle. 2012;11(15):2782-92. doi: https://doi.org/10.4161/cc.20948
Wahdan-Alaswad RR, Fan Z, Edgerton SM, et al. Glucose promotes breast cancer aggression and reduces metformin efficacy. Cell Cycle. 2013;12(24):3759-69. doi: https://doi.org/10.4161/cc.26641
Zordoky BN, Bark D, Soltys CL, et al. The anti-proliferative effect of metformin in triple-negative MDA-MB-231 breast cancer cells is highly dependent on glucose concentration: implications for cancer therapy and prevention. BiochimBiophys 2014 Jun;1840(6):1943-5. doi: https://doi.org/10.1016/j.bbagen.2014.01.023
Oliveras-Ferraros C, Vazquez-Martin A, Cuyas E, et al. Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile. Cell Cycle. 2014;13(7):1132-44. doi: https://doi.org/10.4161/cc.27982
Buac D, Kona FR, Seth AK, Ping DQ. Regulation of metformin response by breast cancer associated gene 2. Neoplasia.2013;15(12):1379-90. doi: https://doi.org/10.1593/neo.131434
Samson SM, Varghese E, et al. Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer. Biomolecules. 2019;9(12):846. doi: https://doi.org/10.3390/biom9120846
Wahdan-Alaswad RS, Edgerton SM, Salem HS, Thor AD. Metformin Targets Glucose Metabolism in Triple Negative Breast Cancer. J Oncol Transl Res. 2018;4(1):129. doi: https://doi.org/10.4172/2476-2261.1000129
Bonanni B, Puntoni M, Cazzaniga M, et al. Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial. J of Clinical Oncology. 2012;30(21):2593-600. doi: https://doi.org/10.1200/JCO.2011.39.3769
He X, Esteva FJ, Ensor J, et al. Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer. Annals of Oncology. 2012;23(7):1771-80. doi: https://doi.org/10.1093/annonc/mdr534
Besic N, Satej N, Ratosa I, Horvat AG, Marinko T, Gazic B, et Long-term use of metformin and the molecular subtype in invasive breast carcinoma patients—a retrospective study of clinical and tumor characteristics. BMC Cancer. 2014 Apr 28;14:298. doi: https://doi.org/10.1186/1471-2407-14-298
MinW, Wang B, Guo A, Mao G, Zhao Y, Zhang S, et The Effect of Metformin on the Clinicopathological Features of Breast Cancer With Type 2 Diabetes. World J Oncol. 2020 Feb;11(1):23-32. doi: https://doi.org/10.14740/wjon1242
CejuelaM, Martin-Castillo B, Menendez JA, Pernas Metformin and Breast Cancer: Where Are We Now? Int J Mol Sci. 2022 Feb 28;23(5):2705. doi: https://doi.org/10.3390/ijms23052705
MónicaC, Martin-Castillo B, Menendez JA, Pernas Metformin and Breast Cancer: Where Are We Now? International Journal of Molecular Sciences. 2022;23(5):2705. doi: https://doi.org/10.3390/ijms23052705
BoyleP, Boniol M, Koechlin A, Robertson C, Valentini F, Coppens K, et al. Diabetes and breast cancer risk: a meta-analysis. Br J Cancer. 2012 Oct 23;107(9):1608-17. doi: https://doi.org/10.1038/bjc.2012.414
NasrazadaniA, Marti JLG, Kip KE, Marroquin OC, Lemon L, Shapiro SD, et Breast cancer mortality as a function of age. Aging (Albany NY). 2022 Feb 8;14(3):1186-99. doi: https://doi.org/10.18632/aging.203881
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021 Jan;71(1):7-33. doi: https://doi.org/10.3322/caac.21654 Erratum in: CA Cancer J Clin. 2021 Jul;71(4):359. PMID: 33433946.
Fayanju OM, Ren Y, Thomas SM, Greenup RA, Plichta JK, Rosenberger LH, et al. The Clinical Significance of Breast-only and Node-only Pathologic Complete Response (pCR) After Neoadjuvant Chemotherapy (NACT): A Review of 20,000 Breast Cancer Patients in the National Cancer Data Base (NCDB). Ann Surg. 2018 Oct;268(4):591-601. doi: https://doi.org/10.1097/SLA.0000000000002953
Ehsan AN, WuCA, Minasian A, Singh T, Bass M, Pace L, et Financial Toxicity Among Patients With Breast Cancer Worldwide: A Systematic Review and Meta-analysis. JAMA Netw Open. 2023 Feb 1;6(2):e2255388. doi: https://doi.org/10.1001/jamanetworkopen.2022.55388
Luangdilok S, Samarnthai N, Korphaisarn K. Association between Pathological Complete Response and Outcome Following Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Patients. J Breast Cancer. 2014 Dec;17(4):376-85. doi: https://doi.org/10.4048/jbc.2014.17.4.376
Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K. Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proc NatlAcad Sci 2014 Jul 22;111(29):10574-9. doi: https://doi.org/10.1073/pnas.1409844111
Rosin J, Svegrup E, Valachis A, et al. Discordance of PIK3CA mutational status between primary and metastatic breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat. 2023;201:161-9. doi: https://doi.org/10.1007/s10549-023-07010-1

PDF

Authors and affiliations

Cite

Metrics

Marshtupa V.V., Nasonova T.I. Clinical, neurological, laboratory and neuropsychological features of the course of cerebrovascular diseases in patients infected with SARS-CoV-2

https://doi.org/10.26641/2307-0404.2023.4.294047

Abstract

The rapid global spread of the COVID-19 virus has caused an unprecedented pandemic, in the conditions of which a significant number of pathological consequences of this disease have appeared. In particular, COVID-19 affected the course of cerebrovascular disease, the consequences of which cause disorders of the normal functioning of the brain. Therefore, the aim of the study was to improve the diagnosis of cerebrovascular disease in patients infected with SARS-CoV-2 by studying clinical, neurological, laboratory and neuropsychological indicators. The trial uses Beck's Anxiety Inventory, Hamilton Depression Rating Scale; neuropsychological tests – Mini-Mental State Examination, Montreal Cognitive Assessment; clinical – neurological status; laboratory – complete blood count, erythrocyte sedimentation rate, C-reactive protein, D-dimer, indicators of the blood coagulation system, procalcitonin; polymerase chain reaction, a test for the detection of ribonucleic acid of the COVID-19 virus; statistical. The revealed results indicate deviations from the norm of most indicators in patients infected with SARS-CoV-2 in particular such as leukocytes (t=3.18, p≤0.01), lymphocytes (t=3.83, p≤0.01), band neutrophils (t=2.33, p≤0.05), segmented neutrophils (t=2.29, p≤0.05), erythrocyte sedimentation rate (t=2.17, p≤0.05), platelets (t =2.86, p≤0.01), prothrombin index (t=3.17, p≤0.01), D-dimer (t=2.11, p≤0.05), fibrinogen (t=2 .53, p≤0.05), C-reactive protein (t=2.97, p≤0.01), procalcitonin (t=2.64, p≤0.05). Patients with a history of SARS-CoV-2 had significantly lower indicators of cognitive (t=-2.17, p≤0.05), visuospatial function (t=-2.84, p≤0.01), as well as a higher level of depression (t=2.87, p≤0.01) than patients who did not suffer from COVID-19. No statistical differences were found in terms of anxiety in both groups. A direct correlation was established between the level of leukocytes and cognitive functions (r=0.477, p≤0.01) and also visuospatial function (r=0.591, p≤0.05). An inverse correlation between procalcitonin level and mental status was also established (r=-0.622, p≤0.01). The conducted study proved the statistical significance of clinical-neurological, laboratory and neuropsychological indicators of patients with cerebrovascular disease infected with SARS-CoV-2.

Key words: SARS-CoV-2, COVID-19, cerebrovascular disease, cognitive functions, laboratory markers, anxiety, depression

References

PDF

Authors and affiliations

Cite

Metrics

Shevchenko O.A., Sheviakov O.V., Kornienko V.V., Burlakova I.A., Slavska Y.A., Zhyhaylo N.I., Vakulik V.V., Ostapenko I.S., Gerasimchuk O.A., Doroshenko E.Y., Prykhodko V.V., Chernihivska S.A., Ivchenko O.M., Tychonovych V.M., Dorogan S.B. Psychophysiological components of the activities of operators of nuclear power plants as a factor of accidents in the conditions of the threat of social catastrophe

https://doi.org/10.26641/2307-0404.2023.4.294160

Abstract

The purpose of the study is to establish the peculiarities of operator’s work and the leading factors of the formation of its psychophysiological tension at nuclear power plants in the conditions of the threat of social catastrophe in connection with military operations. The study was conducted at the Zaporizhzhya and Khmelnytsky nuclear power plants for the period of 2020-2021. To study the dynamics of the psychophysiological state of operators of nuclear power plants, a verbal-communicative diagnostic method was used to collect information about the operators investigated using Google Form and traditional physiological, psychological and psychophysiological methods. The socio-demographic features of the investigated operators of the block control panel were analyzed. It was established that men only (100%) aged 24-49 and with work experience from 4 to 20 years were among the examined. All surveyed operators (41 people) are residents of the city, with completed higher education and are family members. The methods of psychological (reactive anxiety, mood, activity, mood, attention), physiological (cardiography, blood pressure) and psychophysiological (simple sensorimotor and psychophysical) research methods were used to empirically assess the intensity of activity of the operators of the block control panel of nuclear power plants. There were examined operators, while on duty when control errors and pre-accident situations were recorded. It was established that the psychological, physiological and psychophysiological characteristics of these operators are followed by increased reactive anxiety, decreased indicators of well-being, activity, mood, reduction in functional reserves of the cardiorespiratory system, mental and physical capacity. These indicators are considered as criteria for the development of regulatory measures. It is proposed to take into account not only technological factors, but also the psychophysiological features of operators in the dynamics of their manifestation when developing measures for the optimal selection and personnel placement. The complex of methods for researching the functional state of operators can be used to optimize their professional selection and retraining, which can lead to reducing accidents and costs for professional training. The expected effect is an increase in the efficiency and quality of operator’s activity, the productivity and reliability of the performance of production tasks, an increase in professional longevity, a decrease in rate and occupationally-related morbidity of these specialists.

Key words: psychophysiological potential, psychological condition, operators of nuclear power plants, methodical approach, social and medical support, psychophysiological providing

References

Babatenko OV. [Prevention and correction of negative functional states of food industry specialists]. Current problems of psychology. Coll. of science Proceedings of the HS. Kostyuk Institute of Psychology of the National Academy of Sciences of Ukraine. 2019;9(12):16-25.
Fetisov VS. [Package of statistical data analysis STATISTICA]. Nizhin: NSU named after M. Gogol; 2019. р. 100-114. Ukrainian.
Kim TK. A test as parametric statistic. Korean J Anasthesiol. 2019:68(6):540-6. doi:https://doi.org/10.4097/kjae.2019.68.6.540
Kornienko VV. [Conceptualization of the study of the problem of socio-psychological foundations of the rehabilitation potential of the individual. In: Kornienko VV, editor. Theoretical and applied problems of psychology and social work: collection of science Proceedings of the Eastern Ukrainian National University named after Volodymyr Dahl]. Severodonetsk: Publishing house of SNU named after V. Dahl; 2021:36-45 p. doi: https://doi.org/10.33216/2219-2654-2021-56-3-2-169-179
Popovych V, Ragimov F, Ivanova I, Buryk Z. Development of social and communicative paradigm of the field of social networks. International Journal of Data and Network Science. 2020;4:319-28. doi:https://doi.org/10.5267/j.ijdns.2020.6.001
Hillgard SH. Combat stress disorders and the U.S. Military Medicine. 2020;155(11):515-19. doi: https://doi.org/10.1093/milmed/155.11.515
Kashiwagi S. Psychological rating fatigue. Ergonomics. 2021;14:28-33.
Shevchenko O, Burlakova I, Sheviakov O, Agarkov O, Shramko I. Psychological foundations of occupational health of specialists in the economic sphere. Medicni perspectivi.2020;25(2):163-7. doi: https://doi.org/10.26641/2307-0404.2020.2.206890
Sheviakov ОV. [Psychological support for the development of sociotechnical systems]. Dnipropetrovsk: Іnnovation; 2009. p. 275-95. Ukrainian.
Sheviakov OV, Doroshenko EYu, Mykhalyuk YeL, Prikhodko VV, Lyakhova IM, Nikanorov OK, et al. [Features of social and psychological rehabilitation of sportsmen-paralympians specialized in powerlifting]. Zaporozhye medical journal. 2020;22(1);96-102.doi: https://doi.org/10.14739/2310-1210.2020.1.194632
Sheviakov O, Gerasimchuk O. Psychological aspects of formation of professional health safety of specialists System. International security studios managerial, economic, technical, legal, environmental, informative and psychological aspects: collective monograph. Tbilisi: International Educations and scientifists Foundation; 2023. p. 1133-47.
Sheviakov O, Burlakova I, Kornienko V, Vakukik V, Slavska Ya, et al. Psychoprophylaxis of the professional training crisis. Phylosophy, Economics and Law Review. 2022;2(1):7-15.
Zhyhailo N, Sheviakov O, Burlakova I, Slavska Ya, Ostapenko I, Gerasimchuk O. Psychoprophylaxis of the professional training crisis. Scientific Bulletin of Dnipropetrovsk State University of Internal Affairs. 2022;1:317-24.
Zhyhailo N, Sheviakov O, Burlakova I, Slavska Ya, Ostapenko I, Gerasimchuk O. System of psychological support for the development of rehabilitation potential of power structures specialists. Public administration and Law Review. 2023;1(13):62-76. doi: https://doi.org/10.36690/2674-5216-2022-1-57
Shramko ІА. [Social support of women in dynamic socio-technical systems of activity]. Habitus. 2020;18;150-4. Ukrainian.
Zhyhailo N, Sheviakov O, Shu Gao Han, Khomulenko T. The history of war survial culture and the art of victory. Phylosophy, Economics and Law Review. 2022;2(2):48-63. doi: https://doi.org/10.31733/2786-491X-2022-2-48-63

PDF

Authors and affiliations

Shevchenko O.A. Dnipro State Medical University, Dnipro, Ukraine,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-2295-170X

Sheviakov O.V. Dnipropetrovsk State University of Internal Affairs, Dnipro, Ukraine,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-8348-1935

Kornienko V.V. Dnipropetrovsk State University of Internal Affairs, Dnipro, Ukraine,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-8043-3046

Burlakova I.A. Dnipropetrovsk State University of Internal Affairs, Dnipro, Ukraine,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-6043-4359

Slavska Y.A. Dnipropetrovsk State University of Internal Affairs, Dnipro, Ukraine,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-2498-3323

Zhyhaylo N.I. Ivan Franko National University, Lviv, Ukraine,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-5686-2652

Vakulik V.V. Dnipro state agrarian and economic university, Dnipro, Ukraine,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-8773-2287

Ostapenko I.S. Ukrainian State University of Science and Technologies, Dnipro, Ukraine
https://orcid.org/0000-0003-2232-7138

Gerasimchuk O.A. Ukrainian State University of Science and Technologies, Dnipro, Ukraine,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0003-1412-5288

Doroshenko E.Y. Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Prykhodko V.V. Dnipro State Academy of Physical Culture and Sports, Dnipro, Ukraine,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0001-6980-1402

Chernihivska S.A. Dnipro University of Technology, Dnipro, Ukraine
https://orcid.org/0000-0001-7342-438X

Ivchenko O.M. Ukrainian State University of Chemistry and Technology, Dnipro, Ukraine
https://orcid.org/0000-0003-0806-0860

Tychonovych V.M. Kharkiv Trade and Economics College of the State Trade and Economics University, Kharkiv, Ukraine,
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
https://orcid.org/0000-0002-0232-3001

Dorogan S.B. Donetsk national medical university, Kropyvnytskyi, Ukraine
https://orcid.org/0000-0002-6920-4461

Cite

Metrics

Maruta N.O., Fedchenko V.Y., Yavdak I.O., Panko T.V. The impact of biological and psychosocial factors on the formation of mental disorders in patients who have experienced COVID-19 and exposed to the stressors of the SARS-COV-2 pandemic

https://doi.org/10.26641/2307-0404.2023.4.294190

Abstract

The article is devoted to aspects of the formation of clinical manifestations of mental disorders during the COVID-19 pandemic. The goal – to investigate the clinical and anamnestic features and their impact on the formation of psychopathological consequences in patients with first diagnosed mental disorders who have experienced COVID-19 and exposed to the stressors of the SARS-CoV-2 pandemic. 97 patients with first diagnosed mental disorders who have experienced COVID-19 and exposed to the stressors of the SARS-CoV-2 pandemic were examined and made up the main group. The comparison group included 58 people without mental disorders who have experienced COVID-19 and exposed to the stressors of the SARS-CoV-2 pandemic. During the study, a thorough analysis of the anamnesis of the disease was carried out, including information about the experienced coronavirus disease COVID-19, the impact of the stressors of the SARS-COV-2 pandemic, and the features of the initial psychopathological manifestations. Clinical-psychopathological, clinical-amnestic methods using the developed questionnaire containing questions that reflect the impact of the coronavirus disease COVID-19 and the stressors of the SARS-CoV-2 pandemic on the mental health of the general population, classification of COVID-19 by degree of severity, "empirical" percentage visual scale (KT 0-4), and methods of statistical analysis were applied. The obtained data of a comprehensive study made it possible to distinguish among patients with first diagnosed mental disorders 3 subgroups with characteristic differences in the course and conditions of treatment of the experienced coronavirus disease COVID-19, the structure and significance of the stressors of the SARS-COV-2 pandemic, which the patients encountered, initial psychopathological manifestations. It has been established that the psychopathological consequences of the complex impact of the coronavirus disease COVID-19 and the stressors of the SARS-CoV-2 pandemic lead to the formation of first diagnosed mental disorders in individuals from the general population, among whom the most common forms of mental pathology are depressive episodes, neurotic, associated with stress and somatoform disorders and organic mental disorders. The significance of the obtained data lies in the possibility of studying the role of the psychopathological consequences of COVID-19 in the genesis of mental disorders.

Key words: mental disorders, coronavirus disease COVID-19, pandemic, stressors, impact

References

Santomauro DF, Mantilla Herrera AM, Shadid J, Zheng P, Ashbaugh C, Pigott DM, et al. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the Covid-19 pandemic. Lancet.2021;398:1700-12. doi: https://doi.org/10.1016/S0140-6736(21)02143-7
Taquet M, Luciano S, Geddes JR, Harrison PJ. Bidirectional associations between Covid-19 and psychiatric disorder: retrospective cohort studies of 62 354 Covid-19 cases in the USA. Lancet Psychiatry. 2021;8:130-40. doi: https://doi.org/10.1016/S2215-0366(20)30462-4
Bower M, Smout S, Donohoe-Bales A, O’Dean S, Teesson L, Boyle J, et al. A hidden pandemic? An umbrella review of global evidence on mental health in the time of COVID-19. Front 2023;14:1107560. doi: https://doi.org/10.3389/fpsyt.2023.1107560
Babicki M, Bogudzińska B, Kowalski K, Mastalerz-Migas A. Depression, Anxiety and Quality of Life among Online Responders in Poland: A Cross-Sectional Study Covering Four Waves of the COVID-19 Pandemic. Int J Environ Res Public Health. 2022;19:9934. doi: https://doi.org/10.3390/ijerph19169934
Mauz E, Walther L, Junker S, Kersjes C, Damerow S, Eicher S, et al. Time trends in mental health indicators in Germany’s adult population before and during the COVID-19 pandemic. Front Public Health. 2023;11:1065938. doi: https://doi.org/10.3389/fpubh.2023.1065938
Canal-Rivero M, Vazquez-Hernandez J, Leon-Gomez M, Maraver-Ayala S, Fernandez-Portes L, Sanhez-Benítez S, et al. Epidemiology of infection, transmission and COVID-19 outcomes among mental health users and workers in a comprehensive network of long-term mental health facilities: Retrospective observational population-base study. Schizophr Res. 2023 Apr;254:1-7. doi: https://doi.org/10.1016/j.schres.2023.01.020
Tancredi S, Ulytė A, Wagner С, Keidel D, Witzig M, Imboden M, et al. Changes in socioeconomic resources and mental health after the second COVID-19 wave (2020–2021): a longitudinal study in Switzerland. Int J Environ Res Public Health. 2023 Feb;20(3):2000. doi: https://doi.org/10.1186/s12939-023-01853-2
Jeon H-L, Kwon JS, Park S-H, Shin J-Y. Association of mental disorders with SARS-CoV-2 infection and severe health outcomes: nationwide cohort study. Br J Psychiatry.2021;218:344-51. doi: https://doi.org/10.1192/bjp.2020.251
Yang H, Chen W, Hu Y, Chen Y, Zeng Y, Sun Y, et al. Pre-pandemic psychiatric disorders and risk of COVID-19: a UK biobank cohort analysis. Lancet Heal Longev. 2020;1:e69-e79. doi: https://doi.org/10.1016/S2666-7568(20)30013-1
Kunzler AM, Lindner S, Röthke N, Schäfer SK, Metzendorf M-I, Sachkova A, et al. Mental Health Impact of Early Stages of the COVID-19 Pandemic on Individuals with Pre-Existing Mental Disorders: A Systematic Review of Longitudinal Research. Int J Environ Res Public Health. 2023;20:948. doi: https://doi.org/10.3390/ijerph20020948
Zhang K, Zhou X, Liu H, Hashimoto K. Treatment concerns for psychiatric symptoms in patients with COVID-19 with or without psychiatric disorders. Br J Psychiatry.2020;217:351. doi: https://doi.org/10.1192/bjp.2020.84
Muehlschlegel PA, Parkinson EA, Chan RY, Arden MA, Armitage CJ. Learning from previous lockdown measures and Minimising harmful biopsychosocial consequences as they end: a systematic review. J Glob Health. 2021;11:05008. doi: https://doi.org/10.7189/jogh.11.05008
Cenat JM, Blais-Rochette C, Kokou-Kpolou CK, Noorishad PG, Mukunzi JN, McIntee SE, et al. Prevalence of symptoms of depression, anxiety, insomnia, posttraumatic stress disorder, and psychological distress among populations affected by the Covid-19 pandemic: a systematic review and meta-analysis. Psychiatry 2021;295:113599. doi: https://doi.org/10.1016/j.psychres.2020.113599
United Nations. Policy Brief: COVID-19 and the Need for Action on Mental Health [Internet]. 2020 May [cited 2023 Apr 12]. Available from: https://unsdg.un.org/sites/default/files/2020-05/UN-Policy-Brief-COVID-19-and-mental-health.pdf
Maruta NO, Fedchenko VY, Yavdak IO, Panko TV. [Copyright of the work: Questionnaire for patients with mental disorders who have experienced the coronavirus disease COVID-19 and were exposed to the stressors of the SARS-COV-2 pandemic]. Application from 13 Mar 2023 с202301564; certificate from 11 Apr 2023 No. 118009. Ukrainian.
[On making changes to the Medical Care Standards "Coronavirus Disease (COVID-19)". Order of the Ministry of Health of Ukraine from 2020 Oct 27 No. 2438]. [Internet]. 2020 [cited 2023 Apr 12]. Ukrainian. Available from: https://moz.gov.ua/article/ministry-mandates/nakaz-moz-ukraini-vid-27102020--2438-pro-vnesennja-zmin-do-standartiv-medichnoi-dopomogi-koronavirusna-hvoroba-covid-19
Yang R, Li X, Liu H, et al. Chest CT Severity Score: an imaging tool for assessing severe COVID-19. Radiol Cardiothorac 2020;2(2):200047. doi: https://doi.org/10.1148/ryct.2020200047
Walters SJ, Campbell MJ, Machin D. Medical Statistics: A Textbook for the Health Sciences. 5th ed. Wiley-Blackwell; 2021. 448 p.

PDF

Authors and affiliations

Cite

Metrics

Merhavy Z.I., Varkey T.C., Kotyk T., Zeitler C. Sexual health preparedness among medical students

https://doi.org/10.26641/2307-0404.2023.4.294193

Abstract

It has been found that many medical students and early career physicians express feelings of being unprepared and undereducated on topics relating to patient sexual health. Based on previous reports on the topic, the quality and quantity of sexual health education in medical school has been minimally improved over the last several years. Aim of the work is to identify possible deficiencies in sexual health preparation within current medical education curriculum among United States allopathic, osteopathic, and Caribbean medical programs. Medical students (n=100) from three different medical program types, including United States allopathic (n=31), United States osteopathic (n=23), and Caribbean allopathic program (n=46), and years of study (1-4), were recruited informally and participated in a 15-question survey regarding their perceptions and experience of sexual health education, training, and preparation at their respective medical school. After obtaining informed consent, students completed this survey through a private form and the data was compared to students of different years, different programs, and different intended specialties. With a sample size of 100 students from three different medical school programs, it was clear that most schools provide some level of sexual health education to students, however, in most cases, the education received was overall perceived as less than adequate by the students. Additionally, it was seen that almost every student indicated a need for their respective institution to provide additional training in both basic sciences as well as in their clinical education to feel more confident in their ability to discuss sexual health priorities with their patients. Current practices in medical education continue to fail to meet student expectations. To create more competent and confident physicians to adequately assist patients in their sexual health needs, more positive curriculum changes need to be made in order to establish a new, higher standard for quality of sexual health care. Small changes at the pre-clinical and clinical level can improve overall student preparedness and confidence when discussing sexual health with patients.

Key words: sexual health, medical education, medical students, sexual education

References

Komlenac N, Siller H, Hochleitner M. Medical students indicate the need for increased sexuality education at an Austrian Medical University. Sex Med. 2019;7(3):318-25. doi: https://doi.org/10.1016/j.esxm.2019.04.002
Beebe S, Payne N, Posid T, Diab D, Horning P, Scimeca A, et al. The lack of sexual health education in medical training leaves students and residents feeling unprepared. J Sex Med. 2021;18(12):1998-2004. doi: https://doi.org/10.1016/j.jsxm.2021.09.011
Mahabamunuge J, Morel K, Budrow J, Tounkel I, Hart C, Briskin C, et al. Increasing medical student confidence in gender and sexual health through a student-initiated lecture series. J Adv Med Educ Prof. 2021;9(4):189-96. doi: https://doi.org/10.30476/JAMP.2021.90099.1398
Mains-Mason JB, Ufomata E, Peebles JK, Dhar CP, Sequeira G, Miller R, et al. Knowledge retention and clinical skills acquisition in sexual and gender minority health curricula: a systematic review. Acad Med. 2022;97(12):1847-53. doi: https://doi.org/10.1097/ACM.0000000000004768
Goh PH, Phuah LA, Hidayat W, Mathew C, Elias A, Jambunathan PK, et al. Comfort in sexual health communication among medical students: evaluating the efficacy of an online reflective workshop. Sex Educ. 2023;1-17. doi: https://doi.org/10.1080/14681811.2023.2244447
Warner C, Carlson S, Crichlow R, Ross MW. Sexual health knowledge of U.S. medical students: a national survey. J Sex Med. 2018;15(8):1093-102. doi: https://doi.org/10.1016/j.jsxm.2018.05.019
French V, Steinauer J. Sexual and reproductive health teaching in undergraduate medical education: a narrative review. Int J Gynaecol Obstet. 2023;163(1):23-30. doi: https://doi.org/10.1002/ijgo.14759
Duh E, Medina SP, Coppersmith N, Adjei N, Roberts MB, Magee S. Sex ed by Brown Med: a student-run curriculum and its impact on sexual health knowledge. Fam Med. 2017;49(10):785-8. PMID: 29190404
Zhao J, Li Y, Wang X, Wang Z, Yu S, Li T. Assessment of knowledge, attitude, and practice of sexual health among students in a Chinese medical college: a cross-sectional study. Sex Med. 2023;11(2):qfad015. doi: https://doi.org/10.1093/sexmed/qfad015
Olímpio LM, Spessoto LCF, Fácio Jr FN. Sexual health education among undergraduate students of medicine. Trans Androl Urol. 2020;9(2):510-5. doi: https://doi.org/10.21037/tau.2020.02.13
Ross MW, Bayer CR, Shindel A, Coleman E. Evaluating the impact of a medical school cohort sexual health course on knowledge, counseling skills and sexual attitude change. BMC Med Edu. 2021;21(1):37. doi: https://doi.org/10.1186/s12909-020-02482-x
Shindel AW, Baazeem A, Eardley I, Coleman E. Sexual health in undergraduate medical education: existing and future needs and platforms. J Sex Med. 2016;13(7):1013-26. doi: https://doi.org/10.1016/j.jsxm.2016.04.069
Okten C, Gezgin Yazici H. Validity and reliability of the Turkish version of the COVID-19-Impact on Quality of Life Scale. Galician Med J. 2022;29(2):E202224. doi: https://doi.org/10.21802/gmj.2022.2.4
Criniti S, Andelloux M, Woodland MB, Montgomery OC, Hartmann SU. The state of sexual health education in U.S. medicine. Am J Sex Educ. 2014;9(1):65-80. doi: https://doi.org/10.1080/15546128.2013.854007
Henrich JB, Viscoli CM, Abraham GD. Medical students’ assessment of education and training in women’s health and in sex and gender differences. J Womens Health (Larchmt).2008;17(5):815-27. doi: https://doi.org/10.1089/jwh.2007.0589
Friedlander R, Mou S, Shearer L. Diversity in reproductive health and human sexuality: assessing attitudes comfort and knowledge in learners before and after pilot curriculum. Fam 2021;53(5):362-5. doi: https://doi.org/10.22454/FamMed.2021.456130
McGarvey E, Peterson C, Pinkerton R, Keller A, Clayton A. Medical students’ perceptions of sexual health issues prior to a curriculum enhancement. Int J Impot Res. 2003;15(S5):S58-66. doi: https://doi.org/10.1038/sj.ijir.3901074
Bourne SJF, Lee CM, Taliaferro E, Zhang AY, Dalomb NF, Panton C, et al. Impact of teaching sexual health education on medical students. Fam Med. 2020;52(7):518-22. doi: https://doi.org/10.22454/FamMed.2020.939791
Gordon EG. A medical education recommendation for improving sexual health and humanism and professionalism. SexMed 2021;9(1):23-35. doi: https://doi.org/10.1016/j.sxmr.2020.10.002
Aburto-Arciniega MB, Escamilla-Santiago RA, Díaz-Olavarrieta CA, Fajardo-Dolci G, Urrutia-Aguilar MaE, Arce-Cedeño A, et al. Sexual health educational intervention in medical students. Gac Med Mex. 2023;156(2):164-170. doi: https://doi.org/10.24875/GMM.M20000354
Saab R, Habib PA, Hamdan M, El Hayek R, Daher D, El Hage Hassan M, et al. Assessing the knowledge, attitudes, and practices of graduating medical students towards sexual health in Lebanon. Int J Gynaecol Obstet. 2022;161(1):51-6. doi: https://doi.org/10.1002/ijgo.14601

PDF

Authors and affiliations

Cite

Metrics

Biliakov A.M., Erhard N.M. Peculiarities of identification of persons who died during martial law (literature review)

https://doi.org/10.26641/2307-0404.2023.4.294204

Abstract

Identification of dead persons in forensic medical practice is key one during the martial law in Ukraine. Nowadays, when new research methods and modern laboratory and instrumental equipment appear, there is a need to improve forensic diagnostics during the identification of unknown persons. The goal was to establish the peculiarity of the identification of dead persons during martial law, to provide practical recommendations for the selection and extraction of biological material during forensic medical examinations of corpses. The reliability of the results and conclusions is ensured by the use of general scientific empirical and theoretical research methods. With the help of the general scientific methods of research (analysis, synthesis, generalization), scientific and informational literary sources by the subject of research are characterized. The level of problematic issues in the profile information was determined and recommendations for solving problematic aspects related to the identification of dead persons were provided. A systematic approach to solving problematic issues made it possible to formulate conclusions to achieve the set goal. The necessity of training experts in the peculiarities of material selection for further DNA identification is substantiated. The need to provide forensic medical experts with the necessary consumables and equipment, as well as urgent revision of the normative acts regulating their activities, has been proven. The features of identification of putrefied persons are characterized, which consist in the possibility of DNA extraction from smears from the wall of the aorta, the wall of the urinary bladder, brain tissue and intact teeth. It is proven that the identification of dead persons during the martial law is complicated by the influence of the thermal factor, as well as pronounced putrefactive changes. In these cases, bones and teeth as the objects of DNA extraction should be preferential. The relevance and practical significance of the use of innovative technologies for the identification of dead persons during martial law have been established. Some issues of regulatory and legal provision of forensic medical identification of dead persons during martial law, the need to improve the procedure for taking biological samples in criminal proceedings, etc. were raised. Directions for their solution are proposed.

Key words: forensic medical identification of the dead, DNA identification of corpse

References

Husieva V. [Problems of identification of a person based on appearance during the investigation of criminal offenses]. Teoriia ta praktyka sudovoi ekspertyzy i kryminalistyky. 2021;2(24):109-22. Ukrainian. doi: https://doi.org/10.32353/khrife.2.2021.07
Prajapati G, Sarode SC, Sarode GS, Shelke P, Awan KH, Patil S, et al. Role of forensic odontology in the identification of victims of major mass disasters across the world: A systematic review. PLoS One. 2018;13:e0199791. doi: https://doi.org/10.1371/journal.pone.0199791
Cordner S, Tidball-Binz M. Humanitarian forensic action – Its origins and future. Forensic Sci Int. 2017;279:65-71. doi: https://doi.org/10.1016/j.forsciint.2017.08.011
Smitha T, Sheethal HS, Hema KN, Franklin R. Forensic odontology as a humanitarian tool. Journal of Oral and Maxillofacial Pathology. 2019;23(1):164. doi: https://doi.org/10.4103/jomfp.JOMFP_249_18
Caplova Z, Obertova Z, Gibelli DM, De Angelis D, Mazzarelli D, Sforza C, et al. Personal Identification of Deceased Persons: An Overview of the Current Methods Based on Physical Appearance. J Forensic 2018;63(3):662-71. doi: https://doi.org/10.1111/1556-4029.13643
Saranya V, Malathi N. Forensic odontology – A brief review. Sri Ramachandra J Med. 2014;7:22-8.
Reddy AV, Prakash AR, Killampalli LK, Rajinikanth M, Sreenath G, Sabiha PB, et al. Gender determination using Barr bodies from teeth exposed to high temperatures. JForensic Dent 2017;9:44. doi: https://doi.org/10.4103/0975-1475.206494
Vodanovic M, Brkic H. Dental profiling in forensic sciences. Rad 514 Med Sci. 2012;38:153-62.
Devadiga A. What's the deal with dental records for practicing dentists? Importance in general and forensic dentistry. J Forensic Dent Sci. 2014;6:9-15. doi: https://doi.org/10.4103/0975-1475.127764
Madi HA, Swaid S, Al-Amad S. Assessment of the uniqueness of human dentition. J Forensic Odontostomatol. 2013;31:30-9. PMCID: PMC5734832
Stewart Forrest A. Forensic Odontology. Encyclopedia of Forensic Sciences, Third Edition. 2023;2:630-45. doi: https://doi.org/10.1016/B978-0-12-823677-2.00068-4
Shanbhag VL. Significance of dental records in personal identification in forensic sciences. J Forensic Sci Med.2016;2:39-43.
doi: https://doi.org/10.4103/2349-5014.155551
Mansour H, Sperhake JP, Bekaert B, Krebs O, Friedrich P, Fuhrmann A, et al. New aspects of dental implants and DNA technology in human identification. Forensic science international. 2019;302:109926. doi: https://doi.org/10.1016/j.forsciint.2019.109926
Heinrich A, Güttler FV, Schenkl S, Wagner R, Teichgräber UK Automatic human identification based on dental X-ray radiographs using computer vision. Sci Rep.2020;2;10(1):3801. doi: https://doi.org/10.1038/s41598-020-60817-6
Winburn AP, Tallman SD. Forensic Anthropology. Encyclopedia of Forensic Sciences. Third Edition. 2023;2:482-92.
doi: https://doi.org/10.1016/B978-0-12-823677-2.00082-9
H de Boer H, Blau S, Delabard T, Hackman L. The role of forensic anthropology in disaster victim identification (DVI): recent developments and future prospects. ForensicSci 2018;2(4):303-15. doi: https://doi.org/10.1080/20961790.2018.1480460
Ubelaker DH, Shamlou A, Kunkle A. Contributions of forensic anthropology to positive scientific identification: a critical Review. Forensic Sci Res. 2018;8;4(1):45-50. doi: https://doi.org/10.1080/20961790.2018.1523704
Brough AL, Morgan B, RuttyG Postmortem computed tomography (PMCT) and disaster victim identification. Radiol Med. 2015;120(9):866-73. doi: https://doi.org/10.1007/s11547-015-0556-7
Rutty GN, Biggs MJP, Brough A, Morgan B, Webster P, Heathcote A, et al. Remote post-mortem radiology reporting in disaster victim identification: experience gained in the 2017 Grenfell Tower disaster. International Journal of Legal Medicine. 2020;134:637-43. doi: https://doi.org/10.1007/s00414-019-02109-x
Rutty GN, Alminyah A, Apostol M, Boel LWT, Brough A, Bouwer H, et al. Disaster Victim identification Reporting forms. Journal of Forensic Radiology and Imaging. 2018;S2212–4780(18):30094-7. doi: https://doi.org/10.1016/j.jofri.2018.10.003
Borowska-Solonynko A, Dąbkowska A, Moskała A, Teresiński G, Woźniak K. Radiological examination of mass disaster victims – position statement of the Forensic Imaging Examinations Commission at the Polish Society of Forensic Medicine and Criminology. Arch Med Sadowej 2018;68:201-7. doi: https://doi.org/10.5114/amsik.2018.83098
Garazdyuk MS, Kozovy RV, Kindrativ EO. Complex use of anthropometric and dermatoglyphical methods in identification of an unknown person. Forensic-medical examination.2022;1:45-9. doi: https://doi.org/10.24061/2707-8728.1.2022.7
Kostikov I, Mariiko V, Shcherbakova Yu, Martynenko S, Sirivlia A, Sandalovych B, et al. [Molecular-genetic identification of persons who died during russian armed aggression against Ukraine: successes and challenges]. Forensic Herald. 2023;39(1):10-28. Ukrainian. doi: https://doi.org/10.37025/1992-4437/2023-39-1-10
Stepaniuk R. [Forensic DNA Analysis: Development State and Prospects in Ukraine]. Teoriia ta praktyka sudovoi ekspertyzy i kryminalistyky. 2021;3(25):60-80. Ukrainian. doi: https://doi.org/10.32353/khrife.3.2021.05
Yukhno OO. [Forensic support of the activities of forensic examination institutions and pre-trial bodies investigation and inquiries in combating crime]. Teoriia ta praktyka sudovoi ekspertyzy i kryminalistyky. 2021;23(1):61-74. Ukrainian. doi: https://doi.org/10.32353/khrife.1.2021.04
Funes DSH, Bonilla K, Baudelet M, Bridge C. Morphological and chemical profiling for forensic hair examination: A review of quantitative methods. Forensic science international. 2023;346:111622. doi: https://doi.org/10.1016/j.forsciint.2023.111622
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi: https://doi.org/10.1136/bmj.n71
Kaur S, Kujur M, Rawat B, Upadhyaya M, Varshney KC. Journey of unidentified bodies towards DNA identification: A social, medico-legal and forensic perspective from New Delhi in India. Forensic science international. 2022;341:111470. doi: https://doi.org/10.1016/j.forsciint.2022.111470
INTERPOL protocols. Disaster Victim Identification, or DVI, is the method used to identify victims of mass casualty incidents, either man-made or natural [Internet]. [cited 2023 Jun 12]. Available from: https://www.interpol.int/How-we-work/Forensics/Disaster-Victim-Identification-DVI
Helm K, Matzenauer C, Neuhuber F, Monticelli F, Meyer H, Pittner S, et al. Suitability of specific soft tissue swabs for the forensic identification of highly decomposed bodies. International journal of legal medicine. 2021;135(4):1319-27. doi: https://doi.org/10.1007/s00414-021-02601-3
Mundorff AZ, Amory S, Huel R, Bilić A, Scott AL, Parsons TJ. An economical and efficient method for postmortem DNA sampling in mass fatalities. Forensic science international. Genetics. 2018;36:167-75. doi: https://doi.org/10.1016/j.fsigen.2018.07.009
Boer HH, Maat GJR, Kadarmo DA, Widodo PT, Kloosterman AD, Kal AJ. DNA identification of human remains in Disaster Victim Identification (DVI): An efficient sampling method for muscle, bone, bone marrow and teeth. Forensic science international. 2018;289:253-9. doi: https://doi.org/10.1016/j.forsciint.2018.05.044
Kemp BM, Smith DG. Use of bleach to eliminate contaminating DNA from the surface of bones and teeth. Forensic science international. 2005;154(1):53-61. doi: https://doi.org/10.1016/j.forsciint.2004.11.017
Latham KE, Miller JJ. DNA recovery and analysis from skeletal material in modern forensic contexts. Forensicsciences 2018;4(1):51-9. doi: https://doi.org/10.1080/20961790.2018.1515594
Kumar N, Aparna R, Sharma S. Effect of postmortem interval and conditions of teeth on STR based DNA profiling from unidentified dead bodies. Journal of forensic and legal medicine. 2021;83:102246. doi: https://doi.org/10.1016/j.jflm.2021.102246
Finaughty C, HeathfieldLJ, Kemp V, Márquez-Grant N. Forensic DNA extraction methods for human hard tissue: A systematic literature review and meta-analysis of technologies and sample type Forensic Sci Int Genet. 2023;63:102818. doi: https://doi.org/10.1016/j.fsigen.2022.102818
Voichenko VV, Mishalov VD, Mamedov ShM, Viun VV, Ivashyna OKh. [A comprehensive approach to the forensic medical identification of victims during armed conflicts and disasters]. Sudovo-medychna ekspertyza. 2017;1:20-5. doi: https://doi.org/10.24061/2707-8728.1.2017.5
Ellingham STD, Thompson RJU, Islam M, Taylor G. Estimating temperature exposureof burnt bone – a methodological review. Sci Justice. 2015;55:181-8. doi: https://doi.org/1016/j.scijus.2014.12.002
Holubovych LL, Holubovych PL, Holubovych AL, Voichenko VV, Olkhovskyi VO. [Forensic identification of a burned person by bone remains: monograph]. Kharkiv: FOP Brovin O.V.; 2020. р. 229. Ukrainian.
Waterhouse K. Post-burning fragmentation of calcined bone: implications for remains recovery from fetal fire scenes. J Forensic Leg Med. 2013;20:1112-7. doi: https://doi.org/10.1016/j.jflm.2013.10.004
Waterhouse K. The effect of weather conditions on burnt bone fragmentation. J Forensic Leg Med. 2013;20:489-95. doi: https://doi.org/10.1016/j.jflm.2013.03.016
Emery MV, Bolhofner K, Ghafoor S, Winingear S, Buikstra JE, Fulginiti LC. Stone ACWhole mitochondrial genomes assembled from thermally altered forensic bones and teeth. Forensic science international. Genetics. 2022;56:102610. doi: https://doi.org/10.1016/j.fsigen.2021.102610
Steadman DW, Diantonio LL, Wilson J, Sheridan KE, Tammariello SP. The effects of chemical and heat maceration techniques on the recovery nuclear mitochondrial DNA from bone. J Forensic Sci. 2006;51(1):11-7. doi: https://doi.org/10.1111/j.1556-4029.2005.00001.x
Campos PF, Craig OE, Turner-Walker G, Peacock E, Willerslev E, Gilbert MTP. DNA in ancient bone – Where is it located and how should we extract it? Ann Anat.2012;194:7-16. doi: https://doi.org/10.1016/j.aanat.2011.07.003
Imaizumi K, Taniguchi K, Ogawa Y. DNA survival and physical and histological properties of heat-induced alterations in burnt bones. Int J Legal Med. 2014;128:439-46. doi: https://doi.org/10.1007/s00414-014-0988-y
Ensenberger MG, Lenz KA, Matthies LK, Hadinoto GM, Schienman JE, Przech AJ, et al. Developmental validation of the PowerPlex® Fusion 6C System. Forensic science international. Genetics. 2016;21:134-44. doi: https://doi.org/10.1016/j.fsigen.2015.12.011
Voichenko VV, Viun VV, Cherniak VV, Levchenko VV. [Humanitarian mission of forensic medical service for identification of the dead]. Sudovo-medychna ekspertyza.2023;1:85-8. doi: https://doi.org/10.24061/2707-8728.1.2023.12
Rodriguez AL, Smiley-McDonald HM, Cummings MS, Wire S, Slack D, Williams CL, et al. Understanding unidentified human remains investigations through the United States census data. Forensic Science International: Synergy. 2022;4:100225. doi: https://doi.org/10.1016/j.fsisyn.2022.100225
[About the state registration of human genomic information. The law of Ukraine no 2022 Jul 09 No. 2391-IX]. [Internet]. [cited 2023 Jun 12]. Ukrainian. Available from: https://zakon.rada.gov.ua/laws/show/2391-20#Text
Hurov OM, Antonov AH, Surhai NM, Tatarko SV, Shylan VI, Uzbek TS. [Ways of improving forensic medical identification of a person in difficult conditions]. Sudovo-medychna ekspertyza. 2023;1:16-21. Ukrainian. doi: https://doi.org/10.24061/2707-8728.1.2023.3

PDF

Authors and affiliations

Cite

Metrics

Kushta A.O., Shuvalov S.M. Long-term postoperative regional analgesia of the lower third of the face in patients with tumors of the oral cavity

https://doi.org/10.26641/2307-0404.2023.4.294211

Abstract

Pain has a certain number of physical, psychological and social consequences. Pain is of particular importance in the postoperative period for patients with tumors of the oral cavity and of the oropharynx. The effectiveness of analgesia in the postoperative period is a serious problem in maxillofacial surgery. Postoperative pain is not always removable, sometimes it becomes chronic. Pronounced pain syndrome in the postoperative period is experienced by 40 to 75% of patients, but 50% of patients experience pain of medium and high intensity. The aim of this study was a comparative assessment of the effectiveness of a new alternative method of a long-term postoperative regional analgesia and the use of non-narcotic analgesics in patients with tumors of the oral cavity and oropharynx in the postoperative period. The study was conducted in 48 patients (38 men, 10 women, average age 58,05±12,31 years) with tumors of the oral cavity and oropharynx. Patients were divided into two groups depending on the method of postoperative analgesia. In the main group (22 patients) pain was suppressed by a long-term postoperative regional analgesia. In the control group (26 patients) analgesia was performed with non-narcotic analgesics. To control the effectiveness of analgesia, a visual analog scale was used, the duration of analgesia and the manifestation of dysphagia on the day 1, 3 and 10 after surgical intervention as well as similar effects were assessed. On the day 10 of using a long-term postoperative regional analgesia, a positive trend towards a reduction in pain syndrome was observed (2.0±0.63), in contrast to drugs of general action (p<0.05). Over the course of a long-term postoperative regional analgesia it was noted that analgesic effect increases from blockade to blockade. In 80% of patients of the main group, stage II-IVa the act of swallowing was nearly restored, only in 2 patients 2 degree of dysphagia was observed (p<0.05). The advantage of the proposed method in the adequacy and duration of analgesia was established (p<0.05), as well as a lower frequency of side effects – 9.1% and 23.3%, and restoration of act of swallowing (p<0.05). The technique of long-term postoperative regional analgesia allows reducing the invasiveness of the manipulation.

Key words: oral cavity cancer, analgesia, visual analog scale, dysphagia

References

[Ukrainian cancer registry statistics. Cancer in Ukraine, 2017-2018. Incidence, mortality, activities of oncological service]. [Internet]. Bulletin of National Cancer Registry of Ukraine. 2019 [cited 2022 Nov 20];20:16-7. Ukrainian.Available from: http://ncru.inf.ua/publications/BULL_20/PDF_E/16-17%20prot.pdf
Global Burden of Disease 2019 Cancer Collaboration; Kocarnik JM, Compton K, Dean FE, Fu W, Gaw BL, et al. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019. JAMA Oncol. 2022 Mar 1;8(3):420-44. doi: https://doi.org/10.1001/jamaoncol.2021.6987
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer Journal for 2018;68(6):394-424. doi: https://doi.org/10.3322/caac.21492
Lydiatt WM, Patel SG, O'Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, et al. Head and neck cancers – major changes in the American Joint Committee on cancer eighth edition cancer staging manual. Cancer Journalfor 2017;67(2):122-37. doi: https://doi.org/10.3322/caac.21389
Ueda N, Imai Y, Yamakawa N, Yagyuu T, Tamaki S, Nakashima C, et al. Assessment of facial symmetry by three-dimensional stereophotogrammetry after mandibular reconstruction: A comparison with subjective assessment. Journal of stomatology, oral and maxillofacial surgery.2021;122(1):56-61. doi: https://doi.org/10.1016/j.jormas.2020.04.003
O'Connell JE, Bajwa MS, Schache AG, Shaw RJ. Head and neck reconstruction with free flaps based on the thoracodorsal system. Oral Oncology. 2017;75:46-53. doi: https://doi.org/10.1016/j.oraloncology.2017.10.019
Butterworth CJ, Rogers SN. The zygomatic implant perforated (ZIP) flap: a new technique for combined surgical reconstruction and rapid fixed dental rehabilitation following low-level maxillectomy. International Journal of Implant 2017;3(1):37. doi: https://doi.org/10.1186/s40729-017-0100-8
Berania I, Hosni A, Thomas CM. Evaluating contralateral neck failure in patients with lateralized OPSCC treated with transoral robotic surgery and neck management based on pre-operative SPECT-CT lymphatic mapping. J of Otolaryngol – Head & Neck Surg. 2022;51:47. doi: https://doi.org/10.1186/s40463-022-00563-z
Bell BR, Andersen P, Fernandes R. Oral, Head and Neck Oncology and Reconstructive Surgery. Elsevier; 2018. 968 p. ISBN: 9780323265683. Available from: https://evolve.elsevier.com/cs/product/9780323265683?role=student
Huskisson EC. Measurement of pain. Lancet. 1974;304(7889):1127-31. doi: https://doi.org/10.1016/S0140-6736(74)90884-8
Kravets OV, Protsyk VS, Khlynin OV. [Plastic elimination floor of mouth defects platysma myocutaneous flap]. Clinical Oncology. 2017;3(27):32-4. Ukrainian. Availablefrom: https://www.clinicaloncology.com.ua/wp/wp-content/uploads/2017/09/626.pdf
Dmytriiev D, Dmytriiev K, Stoliarchuk O, Semenenko A. Multiple organ dysfunction syndrome: What do we know about pain management? A narrative review. Anaesthesia Pain Intensive Care. 2019;23(1):84-91. Available from: https://www.apicareonline.com/index.php/APIC/article/view/1003
The team of authors. Control of perioperative pain (Adapted clinical guidance, based on evidence). Pain Medicine.2017;2(4):6-53. Available from: https://painmedicine.org.ua/index.php/pnmdcn/article/view/70/67
Dubrovyna EV. [Local anesthesia in dentistry. Atlas].Poltava; 487 p. Ukrainian.
ISBN 978-966-97027-3-9.
Kushta AO, Shuvalov SM, inventors; Vinnytskyi natsionalnyi medychnyi universytet im. MI. Pyrohova, assignee. [The method of long-term postoperative regional analgesia of the maxillofacial region]. Patent UA 143135. 2020 Jul 10. Ukrainian.
Kushta AO, Shuvalov SM, Kliuchkovska OA, inventors; Vinnytskyi natsionalnyi medychnyi universytet im. MI. Pyrohova, assignee. [The method of determining the effectiveness of the act of swallowing]. Patent UA 150521. 2022 Mar 03. Ukrainian.
Kushta AO, Shuvalov SM, inventors. [The method of objectification of the clinical assessment of dysphagia of the oral cavity and oropharynx]. Certificate of copyright registration for the work No. 114419. 2022 Aug 23. Ukrainian.
Babadzhan VD, Bakumenko NS, Kadykova OI, Kravchun PH, Lytvynenko OYu, Miasoiedov VV, et al. [Methodology of scientific research in medicine]. Kravchun PH, Babadzhan VD, Miasoiedov VV, editors. Kharkiv: KhSMU; 2020. 260 p. Ukrainian. Available from: https://repo.knmu.edu.ua/handle/123456789/26906
Gafarov HO, Shakirov MN, Mirzoev MSh. [The structure of the pain syndrome of advanced stages of malignant neoplasms of the maxillofacial region and the effectiveness of traditional pain therapy]. Russian. Herald of institute of postgraduate education in health sphere. 2013;3:77-81. Available from: http://www.vestnik-ipovszrt.tj/?p=1181
Sokolova NA, Avetikov DS, Bukhanchenko OP, Voloshyna LI, Havryliev VM, inventors; Vyshchyi derzhavnyi navchalnyi zaklad Ukrainy “Ukrainska medychna stomatolohichna akademiia”, assignee. [The method of regional anesthesia for malignant tumors of the lower jaw]. Patent UA 118490. 2017 Aug 10. Ukrainian.

PDF

Authors and affiliations

Cite

Metrics

Lemko O.I., Vantiukh N.V., Reshetar D.V., Lukashchuk S.V. Correction of insulin resistance in patients with chronic obstructive pulmonary disease under the influence of recovery treatment

https://doi.org/10.26641/2307-0404.2023.4.294220

Abstract

According to modern concepts chronic obstructive pulmonary disease (COPD) is accompanied by persistent respiratory symptoms, as well as extrapulmonary systemic manifestations. Insulin resistance and metabolic syndrome belong to the leading causes of comorbidity formation. The aim is to study the possibilities of insulin resistance correction in COPD patients, taking into account the previous COVID-19, under the influence of complex non-pharmacological treatment based on haloaerosoltherapy in connection with the applied treatment complex. Clinical and functional examinations and carbohydrate metabolism investigations were carried out in 115 patients with COPD (GOLD II-III) beyond the acute period before and after the course of recovery treatment. Among them 60 patients were convalescents after COVID-19. The average age of patients was 60,3±1,71 years and duration of COPD – 14,2±0,89 years. A control group 12 practically healthy persons were also examined. The presence of insulin resistance was diagnosed by evaluation of the glucose, insulin, HOMA-IR index and C-peptide levels. Treatment was carried out according to three treatment complexes. The main component of the treatment was the use of haloaerosoltherapy and its combination with singlet oxygen therapy or drinking and inhalation of mineral water. The duration of the course of treatment was 20-21 days. Before treatment the presence of insulin resistance was confirmed in both groups of patients with COPD (without COVID-19 and convalescents after COVID-19). Blood glucose levels were significantly higher in the latter group. After the course of recovery treatment a decrease in insulin resistance was noted, especially in patients who received complex treatment, although complete normalization of the studied indices was not achieved. Thus, insulin resistance is a characteristic, pathogenetically determined metabolic manifestation in COPD, which requires constant monitoring and development of long-term programs of complex clinical management of this contingent of patients, especially beyond the exacerbation period. The use of haloaerosoltherapy, which has a sanative and anti-inflammatory effect and promotes clinical stabilization of COPD, is accompanied by a decrease in the manifestations of insulin resistance. Expressiveness of these changes depend on the applied treatment complex. The most pronounced decrease in insulin resistance in COPD patients was noted in a complex treatment based on haloaerosoltherapy with additional drinking and inhalation use of low-mineralized hydrocarbonate siliceous mineral water.

Key words: COPD, іnsulin resistance, COVID-19, recovery treatment, haloaerosoltherapy

References

Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease (2022 report) [Internet]. [cited 2023 Jan 10]. Available from:https://goldcopd.org/wp-content/uploads/2021/12/GOLD-REPORT-2022-v1.1-22Nov2021_WMV.pdf
Zhou W, Li C, Cao J, Feng J. Metabolic syndrome prevalence in patients with obstructive sleep apnea syndrome and chronic obstructive pulmonary disease: Relationship with systemic inflammation. Clin Respir J. 2020;14(12):1159-65. doi: https://doi.org/10.1111/crj.13253
Vantyukh NV, Lemko ОІ. [Some aspects of insulin resistance formation in chronic obstructive pulmonary disease]. Problems of Endocrine Pathology. 2022;79(1):51-6. Ukrainian. doi: https://doi.org/10.21856/j-PEP.2022.1.07
Zuberi FF, Bader N, Rasheed T, Zuberi BF. Association between insulin resistance and BMI with FEV1 in non-hypoxemic COPD out-patients. The clinical respiratory 2021;15(5):513-21. doi: https://doi.org/10.1111/crj.13336
Ruan W, Yan C, Zhu H, et al. Downregulated level of insulin in COPD patients during AE: role beyond glucose control? Int J Chron Obstruct Pulmon Dis. 2019;(14):1559-66. doi: https://doi.org/10.2147/COPD.S197164
Dogra M, Jaggi S, Aggarwal D, et al. Role of interleukin-6 and insulin resistance as screening markers for metabolic syndrome in patients of chronic obstructive pulmonary disease. A hospital-based cross-sectional study. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace. 2022;92(3):10.4081.6p. doi: https://doi.org/10.4081/monaldi.2021.2024
Machado FVC, Pitta F, Hernandes NA, Bertolini GL. Physiopathological relationship between chronic obstructive pulmonary disease and insulin resistance. Endocrine.2018;61(1):17-22. doi: https://doi.org/10.1007/s12020-018-1554-z
Gómez Antúnez M, Muiño Míguez A, et al. Clinical Characteristics and Prognosis of COPD Patients Hospitalized with SARS-CoV-2. Int J Chron Obstruct Pulmon Dis. 2021;5:3433-45. doi: https://doi.org/10.2147/COPD.S276692
Reiterer M, Rajan M, Gomez-Banoy N, et al. Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2. Cell 2021;33(12):2174-88. doi: https://doi.org/10.1016/j.cmet.2021.10.014
Feshchenko YuI, Iashyna LA, Opimakh SG, et al. [Features of lung impairment due to COVID-19 in patients of the first wave of the pandemic (literature review)]. Medicni perspektivi. 2022;27(4):20-6. Ukrainian. doi: https://doi.org/10.26641/2307-0404.2022.4.271118
MalikJA, Ahmed S, Shinde M, et al. The impact of COVID-19 on comorbidities: a review of recent updates for combating it. Saudi J Biol Sci. 2022;29(5):3586-99. doi: https://doi.org/10.1016/j.sjbs.2022.02.006
Lemko O, Lemko I. Haloaerosoltherapy: mechanisms of curative effect and place in the respiratory rehabilitation. Balneo and PRM Research Journal. 2021;12(4):365-75. doi: https://doi.org/10.12680/balneo.2021.464
Lemko OI. Artificial analogies of speleotherapy and their medical use. In: Techniques&Society: Proceedings of the 18th Congress of Speleology. [Internet]. Savoie Mont Blanc; 2022 [cited 2023 Jan 10];6:365-8. Available from: https://uis-speleo.org/wp-content/uploads/2022/09/ACTES_CONGRES_UIS_WEB_VOLUME_6.pdf
Lemko OI, Vantiukh NV, Reshetar DV. [Possibilities of haloaerosoltherapy as respiratory rehabilitation in the correction of insulinresistance in patients with chronic obstructive pulmonary disease]. Ukr Pulmonol J. 2023;31(1):66-71. doi: https://doi.org/10.31215/2306-4927-2023-31-1-66-71
Antuna-Puente B, Disse E, Rabasa-Lhoret R, et al. How can we measure insulin sensitivity/resistance? Diabetes & Metabolism. 2011;37(3):179-88. doi: https://doi.org/10.1016/j.diabet.2011.01.002
Antomonov MYu. [Mathematical processing and analysis of medical and biological data]. 2nd ed. Kyiv: Medinform; 2017. 578 p. Russian.
BirdSR, Hawley Update on the effects of physical activity on insulin sensitivity in humans. BMJ Open Sport Exerc Med. 2017;2(1):e000143. doi: https://doi.org/10.1136/bmjsem-2016-000143
Kumar AS, Maiya AG, Shastry BA, et al. Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis. Annals of Physical and Rehabilitation Medicine. 2019;62:98-103. doi: https://doi.org/10.1016/j.rehab.2018.11.001
Lemko OI, Lemko IS, Haysak MO. Halotherapy, haloaerosoltherapy: Science and practice. In: Science of Sea Salt: Benefits of Human Health. Dallas, Texas, USA: Taylor Specialty Books, Content Lead: Rajiv Saini; 2022. 243-64 p.
Uysal B, Ulusinan E. The Importance of Halotherapy in the Treatment of COVID-19 Related Diseases. J Clin Exp Invest. 2020;11(4):em00754.7p. doi: https://doi.org/10.29333/jcei/8486
Zabolotna IB, Gushcha SG, Mikhailenko VL. Non-alcoholic fatty liver disease and mineral waters of Ukraine – opportunities of application (experimental-clinical studies). Balneo Research Jornal. 2018;9(3):270-6. doi: http://dx.doi.org/10.12680/balneo.2018.194
Lemko IS, Haysak MO, Dychka LV. Quantitative evaluation of alkalinizing features of natural mineral waters of Transcarpathia. Balneo Research Journal. 2020;11(2):174-9. doi: http://doi.org/10.12680/balneo.2020.336

PDF

Authors and affiliations

Cite

Metrics

Grygus I.M., Nogas A.O., Zdanyuk V.V. Dynamics of movement amplitude indicators in joints of patients with rheumatoid arthritis

https://doi.org/10.26641/2307-0404.2023.4.294222

Abstract

The purpose of the paper is to evaluate the effectiveness of the technology of rehabilitation measures in patients with rheumatoid arthritis according to the dynamics of movements amplitude indicators. Theoretical (analysis and generalization of literary and Internet data), survey, collection of anamnesis, objective examination, anthropometric (goniometry) methods of mathematical statistics. 188 patients with rheumatoid arthritis were examined, of which 156 (83%) were women, 32 (17%) were men, average age was 44.9±7.6 years. The analysis of the goniometric indicators of the joints of hands affected by rheumatoid arthritis after six months of conducted rehabilitation measures showed a significant improvement in the mobility of the radiocarpal joint and hand fingers in the examined patients. In particular, active flexion in the radiocarpal joint significantly increased in patients of the experimental group and was 72.5±6.0º, while in the patients of the control group this indicator was 5.3º less (67.2±5.0º) (р<0.05). A significant result was achieved in restoring flexion of the hand fingers in patients of the experimental group: mobility of the fingers in the metacarpal phalangeal joints was 83.2±3.6º, and in the control group it was 73.4±5.0º, in the proximal interphalangeal joints in patients of the experimental group it was 84.1±3.3º, and in the control group – 67.8±4.8º (р<0.05). Positive dynamics of active movements in the foot and finger joints was also observed in patients of both groups at the end of the study. In the patients of the experimental group, the active dorsiflexion in the ankle joint was 27.7±1.4º, the plantar flexion was 41.3±1.8º, which was significantly better than in patients of the control group in which the observed dorsiflexion was 23.4±1.7º, and plantar flexion – 41.3±1.8º (р<0.05). Accordingly, there was a significant increase in the motor function indicators in the metatarsal phalangeal joints of patients in the experimental group: flexion was up to 37.1±1.4º, extension – up to 39.2±1.0º, compared with the indicators in the control group: flexion – up to 33.5±1.2º, extension – up to 36.2±1.1º (р<0.05). The effectiveness of the developed technology is confirmed by improvement of the results of goniometric indicators in patients of the experimental group compared with the control group.

Key words: rheumatoid arthritis, physical therapy, joints, goniometry, movement amplitude

References

Hont AA, Zarudna OI. [Rrheumatoid arthritis – history, modern views, tactics, results]. Medsestrynstvo. 2020;4:30-6. doi: https://doi.org/10.11603/2411-1597.2020.4.11870
Nogas AO. [The results of X-ray examination and determination of the tila index in patients with rheumatoid arthritis]. Art of Medicine. 2022;4(24):109-13. Ukrainian. doi: https://doi.org/10.21802/artm.2022.4.24.109
Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S, Vos T. Global estimates of the need for rehabilitation based on the Global Burden of Disease Study 2019: systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 2020:396(10267):2006-17. doi: https://doi.org/10.1016/S0140-6736(20)32340-0
Kononenko NM, Chikitkina VV. [Basic Methods of Physical Rehabilitation of Patients with Rheumatoid Arthritis]. Ukrainskyi zhurnal medytsyny, biolohii ta sportu. 2022;7,4(38):19-24. Ukrainian. doi: https://doi.org/10.26693/jmbs07.04.019
Grygus I, Nogas A. Resourses use modern aspects of physical rehabilitation of patients with rheumatoid arthritis. In: Pop T, redaktor. Badania naukowe w rehabilitacji. Rzeszów: Wydawnictwo Uniwersytetu Rzeszowskiego; 2014. р. 80-87. ISBN: 9788379960972
[Rheumatoid arthritis. Adapted evidence-based clinical guidelines. Order of the Ministry of Healt of Ukraine No. 263 of 11 April 2014]. [Internet]. 2014 [cited 2023 Jun 12]. Available from: https://zakononline.com.ua/documents/show/71076___71076
Ponyk RM, Korytko ZI. [Disease and peculiarities of rehabilitation of patients with rheumatoid arthritis in the present time]. Achievements of Clinical and Experimental Medicine. 2019;3:183-7. Ukrainian. doi: https://doi.org/10.11603/1811-2471.2019.v.i3.10504
Babak OI, Rozhdestvenska AO, Zhelezniakova NM, et al. [Management of a patient with joint syndrome. Modern practice of internal medicine with emergency conditions: methodological guidelines for students and intern doctors]. Kharkiv: KhNMU; 2021. 40 р. Ukrainian.
Vizir VA, Buriak VV, Sholokh SH, Zaika IV, Shkolovyi VV. [Basics of diagnosis, treatment and prevention of diseases musculoskeletal system and connective tissue. Module 2. Part 2: study guide to practical classes in internal medicine for students of the 5th year of medical faculties]. Zaporizhzhia: ZDMU; 2021. 174 р. Ukrainian.
Zhuravlova LV, Oliinyk MO, Sikalo YuK, Fedorov VO. [Basics of diagnosis and treatment of joint diseases]. Kyiv: Vydavnychyi dim «Medknyha»; 2020. 272 р. Ukrainian.
Bakaliuk T, Barabash S, Bondarchuk V, et al. [Practical skills of a physical therapist: didactic materials]. Kyiv; 2022. 164 р. Ukrainian.
Nogas AO, Karpinskyi AIu. [Movement-related Activity of Patients with Rheumatoid Arthritis in Physical Rehabilitation]. Physical Education, Sport and Health Culture in Modern Society. 2017;1(37):130-5. Ukrainian. doi: https://doi.org/10.29038/2220-7481-2017-01-130-135
Nogas AO. [Improving the quality of life of patients with rheumatoid arthritis with the help of physical activity]. Rehabilitation & recreation. 2022;13:48-53. Ukrainian. doi: https://doi.org/10.32782/2522-1795.2022.13.6
Boers M. Patient global assessment to define remission in rheumatoid arthritis: quo vadis? Ann Rheum Dis.2021;80:277-9. doi: https://doi.org/10.1136/annrheumdis-2020-218802
Fraenkel L, Bathon JM, England BR, et al. 2021. American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol. 2021;73:1108-23.
Smolen JS, Landewe RB, Bijlsma JW, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis.2020;79:685-99. doi: https://doi.org/10.1136/annrheumdis-2019-216655
Nogas A, Grygus I, Prymachok L. Application physiotherapy in rehabilitation rheumatoid arthritis. Journal of Education, Health and Sport. 2016;6(11):184-94. doi: http://dx.doi.org/10.5281/zenodo.166045
[International classification of functioning, limitations of life activities and health]. Kyiv; 2018. 1048 р. Ukrainian.
Grygus I, Nogas A. Comprehensive analysis of pain syndrome in patients with rheumatoid arthritis. Medicni 2023;28(1):148-52. doi: https://doi.org/10.26641/2307-0404.2023.1.276049
Studenic P, Aletaha D, de Wit M, Stamm TA, Alasti F, Lacaille D, et al. American College of Rheumatology/EULAR Remission Criteria for Rheumatoid Arthritis: 2022 Revision. Arthritis Rheumatol. 2023;75(1):15-22. doi: https://doi.org/10.1002/art.42347
Kostiuk VO, Milkin IV. Statistics: a textbook. Kharkiv: KhNUEMG named after A.M. Beketov; 2015. 166 р.
Nogas AO. [Effectiveness of rehabilitation measures for the restoration of joint function in patients with rheumatoid arthritis]. Rehabilitation and Recreation. 2023;14:71-81. doi: https://doi.org/10.32782/2522-1795.2023.14.8

PDF

Authors and affiliations

Cite

Metrics

Faltová B., Mojžíšová A. The use of art therapy interventions in schools to support schoolchildren in their health and well-being

https://doi.org/10.26641/2307-0404.2023.4.294223

Abstract

The paper explains the importance of art therapy interventions implemented in the school settings to support schoolchildren’s health and well-being. The aim is a literature review as part of a dissertation at the University of South Bohemia in České Budějovice, Czech Republic, which deals with the possibilities for promoting well-being in schoolchildren, meeting their health and psychosocial needs in the context of their school and family environment. The Czech Republic lacks research on the direct implementation of art therapy interventions into the school environment, and the use of art therapy approaches within the Czech school context is unclear. Data for the literature search were obtained from recent Czech and international publications. We used the EDS multi-finder to search for literature sources. The document search was completed for the 2011–2023 period in Czech and English language. Search terms included School based art therapy, art therapy intervention, art therapy and schoolchildren’s mental health, and schoolchildren’s well-being. According to the results of the analysed literature, it is possible to conclude the benefits of art therapy interventions in schools as part of a holistic supportive approach of schools to their pupils and the environment in which they live. Art therapy, as a non-pharmacological medical complementary and alternative therapy, is considered as both prevention and an opportunity to address the acute need to support schoolchildren in their health and well-being. Art therapy interventions in the school setting can offer help in addressing a wide range of problems of schoolchildren, such as mental health issues, uncertainty in forming a child’s identity, overcoming communication difficulties, addictive behaviours, anxiety, depressive moods associated with acute trauma, family conflicts, truancy and school failure. Art therapy interventions in the school setting can boost feelings of safety in the school environment along with comprehensive psychological, educational, and social interventions synthesizing the needs of the child, teacher, parents and other professionals working together to support the health and well-being of schoolchildren.

Key words: art therapy interventions, mental health, well-being, school, schoolchild

References

Doing better for children. Paris: OECD; c2009. ISBN: 978-92-64-05933-7. Available from: https://web-archive.oecd.org/2014-08-21/65780-doingbetterforchildren.htm#Press_material
Lee BJ, Yoo MS. Family, School, and Community Correlates of Children’s Subjective Well-being: An International Comparative Study. Child Indicators Research. 2015;8(1):151-75.
doi: https://doi.org/10.1007/s12187-014-9285-z
Karkou V. Arts therapies in schools: research and practice. Philadelphia: Jessica Kingsley Publishers; 2010. ISBN: 978-1-84310-633-3
Stuckey HL, Nobel J. The Connection Between Art, Healing, and Public Health: A Review of Current Literature. American Journal of Public Health [Internet]. 2010 [cited 2023 Aug 19];100(2):254-63. Available from: https://ajph.aphapublications.org/doi/full/10.2105/AJPH.2008.156497
Dray J. Child and Adolescent Mental Health and Resilience-Focussed Interventions: A Conceptual Analysis to Inform Future Research. International Journal of Environmental Research and Public Health. 2021;18(14):7315. doi: https://doi.org/10.3390/ijerph18147315
Stewart C. Mental health in Europe – statistics & facts [Internet]. Statista. London, United Kingdom; 2022 [cited 2023 May 14]. Available from: https://www.statista.com/topics/7916/mental-health-in-europe/#topicOverview
Mental Health of Children and Young People in England, 2020: Wave 1 follow up to the 2017 survey. NHS England: Official statistics, Survey [Internet]. England: NHS England; 2020 [cited 2023 May 11]. Available from: https://digital.nhs.uk/data-and-information/publications/statistical/mental-health-of-children-and-young-people-in-england/2020-wave-1-follow-up
Mental health and behaviour in schools [Internet]. London, UK: Gov. UK: Department for Education; Nov 2018 [cited 2023 May 10]. Available from: https://www.gov.uk/government/organisations/department-for-education
Social, emotional and mental wellbeing in primary and secondary education: NICE guideline [NG223]. [Internet]. London: National Institute for Health and Care Excellence; 06 Jul 2022AD. [cited 2023 May 25] Available from: https://www.nice.org.uk/guidance/ng223
Fryč J, Matušková Z, Katzová P, Kovář K, Beran J, Valachová I, et al. [Strategy of the educational policy of the Czech Republic up to the year 2030+]. Praha: The Ministry of Education, Youth and Sports; 2020. Czech.
Zubala A, Karkou V. Arts Therapies in the Treatment of Depression. Abingdon, Oxon; New York, NY: Routledge; 2018. Series: International research in the arts therapies: Routledge; 2018. doi: https://doi.org/10.4324/9781315454412
Savytska O, Shkrabiuk V, Pedorenko V, Sytnik S, Naichuk V, Nazarevych V. Art Therapy as a Means of Psychological Correction of Emotional Disorders. BRAIN. Broad Research in Artificial Intelligence and Neuroscience [Internet]. 2022 Dec 21 [cited 2023 Sep 27];13(4):196-211. Available from: https://lumenpublishing.com/journals/index.php/brain/article/view/5126 doi: https://doi.org/10.18662/brain/13.4/383
Moula Z. “I didn't know I have the capacity to be creative”: children's experiences of how creativity promoted their sense of well-being. A pilot randomised controlled study in school arts therapies. Public Health [Internet]. 2021 [cited 2023 Sep 27];197:19-25. doi: https://doi.org/10.1016/j.puhe.2021.06.004
Nielsen F, Isobel S, Starling J. Evaluating the use of responsive art therapy in an inpatient child and adolescent mental health services unit. Australasian Psychiatry [Internet]. 2019 [cited 2023 Sep 27];27(2):165-70. doi: https://doi.org/10.1177/1039856218822745
Šicková-Fabrici J. [Basics of art therapy]. Praha: Portál; 2016. p. 304. Czech.
Valenta M, Krejčová L, Hlebová B. [Disadvantaged pupil: partial function deficits and impaired cognitive performance]. Praha: Grada; 2020. p. 216. Czech.
Ottarsdottir U. Art therapy to address emotional wellbeing of children who have experienced stress and/or trauma. In: Zubala A, Karkou V. Arts Therapies in the Treatment of Depression. Abingdon, Oxon; New York, NY: Routledge, 2018. Ser.: International research in the arts therapies. Routledge; 2018. doi: https://doi.org/10.4324/9781315454412-3
Shukla A, Choudhari SG, Gaidhane AM, Quazi Syed Z. Role of Art Therapy in the Promotion of Mental Health: A Critical Review. Cureus [Internet]. [cited 2023 Apr 20]. doi: https://doi.org/10.7759/cureus.28026
Hu J, Zhang J, Hu L, Yu H, Xu J. Art Therapy: A Complementary Treatment for Mental Disorders. Frontiers in Psychology [Internet]. 2021 Apr 12 [cited 2023 Aug 19];12. doi: https://doi.org/10.3389/fpsyg.2021.686005
Malchiodi C. Breaking the Silence [Internet]. Routledge; 2014 [cited 2023 May 26]. doi: https://doi.org/10.4324/9781315803593
Chiumento A, Nelki J, Dutton C, Hughes G. School‐based mental health service for refugee and asylum seeking children: multi‐agency working, lessons for good practice. Journal of Public Mental Health [Internet]. 2011 Sep 16 [cited 2023 Apr 19];10(3):164-77. doi: https://doi.org/10.1108/17465721111175047
Deboys R. Children's experiences of art therapy [dissertation]. Cantenbury Christ Church University; 2015.
McDonald A, Holttum S. Primary-school-based art therapy: A mixed methods comparison study on children’s classroom learning. International Journal of Art Therapy [Internet]. 2020 Jul 2 [cited 2023 Apr 27];25(3):119-31. doi: https://doi.org/10.1080/17454832.2020.1760906
Kantor J, Chráska M, Ludíková L. Czech Arts Therapies in Educational Institutions. Education Sciences. 2019;9(2):82. doi: https://doi.org/10.3390/educsci9020082
Lhotová M, Perout E. [Arteterapie v souvislostech]. Praha: Portál; 2018. p. 200. Czech.
Slavík J, Chrz V, Štech S. [Creation as a way of knowing]. Praha: Karolinum; 2013. p. 556. Czech.
Berberian M, Davis B. Art Therapy Practices for Resilient Youth. New York, NY: Routledge: Routledge; 2019. doi: https://doi.org/10.4324/9781315229379
Nahkur O, Kutsar D. Social Ecological Measures of Interpersonal Destructiveness Impacting Child Subjective Mental Well-Being: Perceptions of 12-Year-Old Children in 14 Countries. Child Indicators Research. 2019;12(1):353-78.
doi: https://doi.org/10.1007/s12187-018-9542-7
Ramirez K, Haen Amplifying Perspectives: The Experience of Adolescent Males of Color Engaged in School-Based Art Therapy. The Arts in Psychotherapy [Internet]. 2021 [cited 2023 Apr 20];75. doi: https://doi.org/10.1016/j.aip.2021.101835
Ratnik M, Rüütel E. The field of work of the school art therapist and its unique potential for the school´s support team. Problems of Education in the 21st Century [Internet]. 2019 Feb 14 [cited 2023 Apr 26];77(1):142-55. doi: https://doi.org/10.33225/pec/19.77.142
Quinlan R, Schweitzer RD, Khawaja N, Griffin J. Evaluation of a school-based creative arts therapy program for adolescents from refugee backgrounds. The Arts in Psychotherapy [Internet]. 2016 [cited 2023 Apr 22];47:72-8. doi: https://doi.org/10.1016/j.aip.2015.09.006
Moula Z, Powell J, Karkou V. An Investigation of the Effectiveness of Arts Therapies Interventions on Measures of Quality of Life and Wellbeing: A Pilot Randomized Controlled Study in Primary Schools. Frontiers in Psychology[Internet]. 2020 Dec 15 [cited 2023 Apr 26];11. doi: https://doi.org/10.3389/fpsyg.2020.586134
Braito I, Rudd T, Buyuktaskin D, Ahmed M, Glancy C, Mulligan A. Review: systematic review of effectiveness of art psychotherapy in children with mental health disorders. Irish Journal of Medical Science (1971 -) [Internet]. 2022 [cited 2023 Aug 19];191(3):1369-83. doi: https://doi.org/10.1007/s11845-021-02688-y
Berberian M. School-Based Art Therapy. In: Art Therapy Practices for Resilient Youth [Internet]. New York, NY: Routledge: Routledge; 2019 [cited 2023 Aug 19]. 425-46 doi: https://doi.org/10.4324/9781315229379-22
Robinson DR. An exploratory study of art therapy intervention in the primary school: Perspectives of children and art therapists -ORCA (cardiff.ac.uk) [dissertation]. Cardiff University; 2020.
Campbell C. Artful and art full schools: an investigation into art therapy in a mainstream primary school in England [dissertaion]. The University of Manchester; 2019.
Regev D. A process-outcome study of school-based art therapy. International Journal of Art Therapy [Internet]. 2022 Jan 2 [cited 2023 Sep 27];27(1):17-25. doi: https://doi.org/10.1080/17454832.2021.1957960
Snir S. Artmaking in Elementary School Art Therapy: Associations with Pre-Treatment Behavioral Problems and Therapy Outcomes. Children [Internet]. 2022 [cited 2023 Apr 23];9(9):1277. doi: https://doi.org/10.3390/children9091277
Harpazi S, Regev D, Snir S, Raubach-Kaspy R. Perceptions of Art Therapy in Adolescent Clients Treated Within the School System. Frontiers in Psychology [Internet]. 2020 Nov 9 [cited 2023 Apr 26];11:518304. doi: https://doi.org/10.3389/fpsyg.2020.518304
Markland F. Effectiveness of school based art therapy for children who have experienced psychological trauma [dissertation]. The University of Manchester; 2011.

PDF

Authors and affiliations

Cite

Metrics

PREVENTIVE MEDICINE

Zorina O.V., Surmasheva O.V., Polka O.O., Mavrykin Yе.О. Risk assessment when consuming drinking water treated with chlorine dioxide and risk management in EU countries and Ukraine to protect public health

https://doi.org/10.26641/2307-0404.2023.4.294226

Abstract

The purpose of the work was to conduct a comparative scientific analysis of the main approaches to risk assessment and risk management to prevent the negative impact of drinking water on public health when treating it with chlorine dioxide in EU countries and Ukraine. The main risk to the population's health arising when consuming drinking water, is the risk of its microbiologicall contamination. Microbiological contamination of drinking water corresponds to a high risk, while the formation of disinfection byproducts in drinking water is an average risk. The regulatory documents of all EU countries take into account the requirements of Directive 2020/2184/EU regarding the content of chlorites and chlorates in drinking water when treating it with chlorine dioxide, while in Denmark, Slovakia, Hungary, Spain, and France, a risk-oriented approach to the safety of drinking water forced to introduce stricter standards for these indicators (as mandatory, recommended or those, which can be temporarily raised).The scientific analysis of the regulation of drinking water quality in the EU countries and Ukraine, as well as field studies on the safety and quality of drinking water at the Dnipro water station in the city of Kyiv, allowed to assess the risks of drinking water hazards and became the basis for raising the issue of revising or canceling the unscientific standard for chlorine dioxide in drinking water of the distribution network (≥0.1 mg/l), revising the strict standard for chlorites (≤0.2 mg/l), as well as control of drinking water quality by the content of chlorates following the requirements of European legislation. When appointing the organizers, executors, and decision-makers regarding risk assessment, similar approaches were implemented in various EU countries; in the documents of many countries, there are references to the relevant scientific institutions and the functions assigned to them. Under such conditions, the working programs of production control over drinking water quality and modernization plans can be adapted to the relevant water supply system and modern realities.

Key words: drinking water, chlorine dioxide, chlorites, chlorates, risk assessment

References

Evlampidou I, Font-Ribera L, Rojas-Rueda D, Gracia-Lavedan E, Costet N, Pearce N, et al. Trihalomethanes in Drinking Water and Bladder Cancer Burden in the European Union. Environmental Health Perspectives. 2020;128(1):17001. doi: https://doi.org/10.1289/EHP4495
Tsitsifli S, Kanakoudis V. Disinfection Impacts to Drinking Water Safety − A Review. In: Insights on the Water-Energy-Food Nexus. Рroceedings the 3rd EWaS International Conference; 2018 Jun 27-30; Island, Greece; Proceedings. 2018;2(11):603. doi: https://doi.org/10.3390/proceedings2110603
Prokopov VO, Liponetskaia OB, Kulish TV, Sobol VA. [Priming of whiskey with chlorine dioxide for disinfection of water at the Dnipro water supply system in Kyiv. In: Actual nutrition of public health and environmental safety in Ukraine. Сollection of abstracts of reports of the scientific-practical conference]. Kyiv. 2018;18:221-3. Ukrainian.
Novytskyi DYu, Kostyuk VA, Kobylanskyi VYa. [Chlorine dioxide in the aspect of microbiological safety of tap water]. Science Review. 2019;4(21):9-14. Ukrainian. doi: https://doi.org/10.31435/rsglobal_sr/31052019/6487
Özdemir K. Chlorine and chlorine dioxide oxidation of natural organic matter in water treatment plants. Environment Protection Engineering. 2020;46(4): 87-97. doi: https://doi.org/10.37190/epe200407
Mesanagrenou M. [Wаter chlorination as a metod of disinfection]. [Internet]. 2020 [cited 2023 Feb 12]. Greek. Available from: https://www.zythopedia.eu/50
Yu Zhong, Wenhui Gan, Ye Du, et al. Disinfection byproducts and their toxicity in wastewater effluents treated by the mixing oxidant of ClO2/Cl2. Water Research.2019;162:471-81. doi: https://doi.org/10.1016/j.watres.2019.07.012
Prokopov OV, Lypovetska OB, Kulish TV, et al. [Dangerous chlorites in drinking water: formation and removal using chlorine dioxide in water treatment technology]. Environment and health. 2023;1(106):43-50. Ukrainian. doi: https://doi.org/10.32402/dovkil2023.01.043
Meng-Yuan Xu, Yi-Li Lin, Tian-Yang Zhang, et al. Chlorine dioxide-based oxidation processes for water purification: A review. Journal of Hazardous Materials. 2022;436:129195. doi: https://doi.org/10.1016/j.jhazmat.2022.129195
Mokienko AV. [Chlorine dioxide: application in water treatment technologies]. 2nd ed. Odessa: Feniks; 2021. р. 336. Russian.
Antomonov MYu. [Mathematical treatment and analysis of medical and biological data]. 2nd ed. Kyiv: MYCz “Medinform”; 2018. р. 579. Russian.
Jeligova H, Baudisova D, Pumann P, et al. [New legislation and its requirements for risk analysis in the production of drinking water. In: Drinking water: proceedings of the conference]. Czech Budejovice; 2016. p. 125-30. Czech. Available from:
https://szu.cz/wp-content/uploads/2023/02/1_2_Pitna_voda_Tabor_Jeligova_et_al_Legislativa.pdf.
[DSanPiN 2.2.4-171-10. Hygienic Requirements to Drinking Water for Human Consumption]. Kyiv; 2010. р. 99-129. Ukrainian.
[Decree No. 70/2018 Coll. Decree amending Decree No. 252/2004 Coll., which establishes hygienic requirements for drinking and hot water and the frequency and scope of drinking water control, as amended. Effective from 2018 Jul 24]. [Internet]. 2018 [cited 2023 Feb 12]. Czech. Available from: https://www.zakonyprolidi.cz/cs/2018-70/zneni-0

PDF

Authors and affiliations

Cite

Metrics

Lototska-Dudyk U.B., Kuzminov B.P., Chemodurova N.Ye., Turkina V.A. HET-CAM test in evaluation of irritating action of adhesives used in shoe making industry

https://doi.org/10.26641/2307-0404.2023.4.294232

Abstract

The global tendency of the contemporary scientific studies is using alternative biologic models as substitutes of experimental animals. HET-CAM (The Hen's Egg Test on the Chorioallantoie Membrane Assay) is an alternative to in vivo tests involving experimental animals. This test is actively used in different biomedical studies. The aim of our work was to study the irritating potential of adhesives used in shoe making industry in experimental setting using the alternative HET-CAM method. Polyurethane, polychloroprene, rubber and styrene-butadiene adhesives that are widely used in shoe-making industry were studied . HET-CAM test was used for the evaluation of the irritating action of the aforementioned adhesives. All adhesives were applied directly onto the chorioallantoic membrane of chick embryos with reactions and changes (hemorrhages, vascular lysis and coagulation) observed and registered in 30, 120 and 300 seconds after the application of the adhesive. Irritating potential of the adhesives was evaluated according to a calculated irritating index. The most pronounced signs of irritating action were caused by polyurethane adhesives, namely hemorrhages and coagulation (30 sec) – two-component adhesive and hemorrhages (30 sec) and coagulation (120-300 sec) – one-component adhesive. Vascular reactions from application of styrene-butadiene adhesives manifested predominantly with lysis and hemorrhages (30 sec), in some samples these reactions were observed at a later time-point (120-300 sec). Irritating action of rubber adhesives manifested mostly with hemorrhages (30 sec), one observation showed lysis (120 sec). Polychloroprene adhesive caused hemorrhages (30-120 sec) and also lysis (30 sec) in one of the samples. According to the irritating index, polyurethane (one- and two-component) and styrene-butadiene adhesives were estimated to be strong irritants, while rubber and polychloroprene ones cause moderate irritating action. НЕТ-САМ test can be used as a component in the evaluation of evidence of irritating action of shoe adhesives.

Key words: shoe adhesives, irritating action, the hen's egg test on the chorioallantoie membrane assay, in vitro method

References

Maestri E. The 3Rs principle in animal experimentation: A legal review of the state of the art in Europe and the case in Italy. BioTech (Basel). 2021;10(2):9. doi: https://doi.org/10.3390/biotech10020009
Laroche C, Annys E, Bender H, Botelho D, et al. Finding synergies for the 3Rs - Repeated Dose Toxicity testing: Report from an EPAA Partners' Forum. Regul Toxicol 2019;108:104470. doi: https://doi.org/10.1016/j.yrtph.2019.104470
Vimalraj S, Renugaa S, Dhanasekaran A. Chick embryo chorioallantoic membrane: a biomaterial testing platform for tissue engineering applications. Process Biochemistry.2023;124:81-91. doi: https://doi.org/10.1016/j.procbio.2022.11.007
Harnoss JC, Abu Elrub QM, Jung J, Koburger T, et al. Irritative potency of selected wound antiseptics in the hen's egg test on chorioallantoic membrane to predict their compatibility to wounds. Wound Repair and Regeneration. 2019;27(2):183-9. doi: https://doi.org/10.1111/wrr.12689
Rivero MN, Lenze M, Izaguirre M, Damonte SH, et al. Comparison between HET-CAM protocols and a product use clinical study for eye irritation evaluation of personal care products including cosmetics according to their surfactant composition. Food and Chemical Toxicology. 2021;153:112229. doi: https://doi.org/10.1016/j.fct.2021.112229
Budai P, Kormos É, Buda I, et al. Comparative evaluation of HET-CAM and ICE methods for objective assessment of ocular irritation caused by selected pesticide products. Toxicology in vitro. 2021;74:105150. doi: https://doi.org/10.1016/j.tiv.2021.105150
Talaei S, Mahboobian MM, Mohammadi M. Investigating the ocular toxicity potential and therapeutic efficiency of in situ gel nanoemulsion formulations of brinzolamide. Toxicology Research. 2020;9:578-87. doi: https://doi.org/10.1093/toxres/tfaa066
Chen L, Wang S, Feng Y, Zhang J, et al. Utilisation of chick embryo chorioallantoic membrane as a model platform for imaging-navigated biomedical research. Cells. 2021;10(2):463. doi: https://doi.org/10.3390/cells10020463
Viera LM, Silva RS, da Silva CC, Presgrave OA, et al. Comparison of the different protocols of the Hen's Egg Test-Chorioallantoic Membrane (HET-CAM) by evaluating the eye irritation potential of surfactants. Toxicol in vitro.2022;78:105255. doi: https://doi.org/10.1016/j.tiv.2021.105255
Ribatti D. The chick embryo chorioallantoic membrane (CAM) assay. Reprod Toxicol. 2017;70:97-101. doi: https://doi.org/10.1016/j.reprotox.2016.11.004
Kuzminov BP, Turkina VA, Chemodurova NYe. [Methodological guidelines. Evaluation of irritation action of substances on the chorioallantoic membrane of the chick embryo (HET-CAM test)]. Lviv; 2023. р. 20. doi: https://doi.org/10.13140/RG.2.2.32544.56322
Antomonov MYu. [Mathematical processing and analysis of medical and biological data]. Кyiv: MYCz "Medynform"; 2018. р. 579. Russian.
Lukács J, Präßler J, Gebhardt M, Elsner P. Adhesives and glues. Kanerva’s Occupational Dermatology. Springer; р. 891-900. doi: https://doi.org/10.1007/978-3-319-68617-2_59
Paiva RM, Marques EA, da Silva LF, António CA, Arán-Ais F. Adhesives in the footwear industry. Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications. 2016;230(2):357-74. doi: https://doi.org/10.1177/1464420715602441
Orgiles-Calpena ME, Aran-Ais F, Torro-Palau AM, et al. Adhesives in the footwear industry: a critical review. Rev Adhesion Adhesives. 2019;7(1):69-91. doi: https://doi.org/10.7569/RAA.2019.097303
Schenk L, Rauma M, Fransson MN, Johanson G. Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin. PLoS One. 2019;13(10):e0205458. doi: https://doi.org/10.1371/journal.pone.0205458
Vinardell MP, Mitjans M. The chorioallantoic membrane test as a model to predict the potential human eye irritation induced by commonly used laboratory solvents.Toxicol in vitro. 2006;20(6):1066-70. doi: https://doi.org/10.1016/j.tiv.2005.11.004
Scholten B, Kenny L, Duca RC, et al. Biomonitoring for occupational exposure to diisocyanates: A systematic review. Ann Work Expo Health. 2020 Jul 1;64(6):569-85. doi: https://doi.org/10.1093/annweh/wxaa038
Jones K, Galea KS, Scholten B, et al. HBM4EU Diisocyanates study-research protocol for a collaborative european human biological monitoring study on occupational exposure. Int J Environ Res Public Health. 2022 Jul 20;19(14):8811. doi: https://doi.org/10.3390/ijerph19148811
Shebe KhA. Сontact dermatitis caused by synthetic glue. Current Allergy & Clinical Immunology. 2013;26(3):152-5.
Han J, Lee GY, Bae G, Kang MJ, et al. ChemSkin reference chemical database for the development of an in vitro skin irritation test. Toxics. 2021;9(11):314. doi: https://doi.org/10.3390/toxics9110314
Schrage A, Gamer AO, van Ravenzwaay B, Landsiedel R. Experience with the HET-CAM method in the routine testing of a broad variety of chemicals and formulations. Altern Lab Anim. 2010;38(1):39-52. doi: https://doi.org/10.1177/026119291003800109
Fraguas-Sánchez AI, Martín-Sabroso C, Torres-Suárez AI. The chick embryo chorioallantoic membrane model: a research approach for ex vivo and in vivo experiments. Curr Med Chem. 2022;29(10):1702-17. doi: https://doi.org/10.2174/0929867328666210625105438

PDF

Authors and affiliations

Cite

Metrics

Ignatov I. Review of different types of mountain springs and mineral waters from Bulgaria based on their natural origin and health benefits

https://doi.org/10.26641/2307-0404.2023.4.294236

Abstract

Mineral water has been renowned for its health benefits for over two millennia, with historical records indicating its use for rapid recovery and wound healing, especially among soldiers engaged in military activities. Over time, baths with mineral water became popular for therapeutic purposes. In the 19^th century, analyses revealed that regions with mountains boasted many long-lived individuals and centenarians, with factors such as pure mountain water, fresh air, and quality food potentially contributing to longevity. This publication comprehensively reviews selected natural waters, including mineral and mountain waters. The author conducted extensive studies in Bulgaria from 2012 to 2019 involving 477 long-lived individuals and their brothers and sisters living in mountain and field areas. The investigation assessed their heredity, body weight, health, psychological status, tobacco smoking, physical activity, food, and water consumption. Emphasizing the importance of medical prevention and care, the study sheds light on essential aspects of longevity today. One significant conclusion drawn from this research is the crucial role of balancing certain minerals in both water and food for human health and longevity. These minerals include Calcium (Ca²⁺), Magnesium (Mg²⁺), Sodium (Na⁺), Potassium (K⁺), Zinc (Zn²⁺), and Manganese (Mn²⁺). Furthermore, a detailed analysis of the physicochemical properties of water in longevity zones reveals lower calcium ions (Ca²⁺) levels compared to other regions, ranging from 6 to 20 mg.L^-1. Notably, regions like Nova Scotia, Canada, known for supercentenarians for over 110 years, have water with such calcium levels. Similarly, longevity is observed in areas of Greece characterized by Mediterranean cuisine and mountain water. Water's physicochemical composition is significantly influenced by its natural filtration through rocks, which imbues it with beneficial minerals.

Key words: mineral water, spring mountain water, health, longevity, analyses

References

Hristov V, Stoyanov N, Valtchev S, et al. Utilization of low enthalpy geothermal energy in Bulgaria. IOP Conf. Ser.: Earth Environ Sci.; 249; 2019; 012035. doi: https://doi.org/10.1088/1755-1315/249/1/012035
Sinnyovsky D, Kalutskova N, Dronin N, Sinnyovska D, Medvedev A, Telnova N. Concepts of geoparks establishment in Bulgaria and their geothermal resources. IOP Conf. Ser.: Earth Environ. Sci.; 367; 2019; 012006. doi: https://doi.org/10.1088/1755-1315/367/1/012006
Orehova T, Bojilova EK. Hydrological assessment for selected Karstic springs in the mountain regions of Bulgaria. In: Wiegandt E, editor. Mountains: Sources of Water, Sources of Knowledge. Advances in Global Change Research. 2008. 31 р.
doi: https://doi.org/10.1007/978-1-4020-6748-8_16
About the quality of water intended for drinking purposes. Ordinance 9. Official State Gazette. 2001;30.
Adopting the Regulation on requirements for bottled natural mineral, spring, and table waters intended for drinking purposes. Decree No. 178/23.07.2004.
Ignatov I. Research of the factors of health and longevity of the population in Bulgaria. Bulgarian Journal of Public Health. 2018;10(1):34-50.
Ignatov I, Valcheva N. Physicochemical, isotopic, spectral, and microbiological analyses of water from glacier Mappa, Chilean Andes. Journal of the Chilean Chemical Society. 2023;68(1):5802-906. doi: https://doi.org/10.4067/S0717-97072023000105802
Valcheva N, Koleva Y. Physicochemical and microbiological characteristics of thermal healing spring waters in Sofia, Bulgaria. Journal of Environmental Protection and Ecology. 2023;24(3):729-35.
Hristov V, Valtchev S, Trayanova M, Atanassova R, Benderev A. Mineral water bottling in Bulgaria. Geologica 2023;52(2):53-64. doi: https://doi.org/10.52321/GeolBalc.52.2.53
Yoleva A, Djambazov S, Sabrieva S. Preparation of ceramic membranes for microfiltration based on marl clay and natural zeolite from deposits in Bulgaria. Journal of Chemical Technology and Metallurgy. 2021;56(2):302-6.
Popova TP, Ignatov I, Valcheva N, Ignatov AI. Research of zeolite and zeolite water from the Rhodope Mountains, Bulgaria. Journal of the Turkish Chemical Society Section A: Chemistry. 2022;9(3):901-8. doi: https://doi.org/10.18596/jotcsa.1058556
Ignatov I, Ignatov AI, Angelcheva M, Angushev I. The international event "Days of Mountain Water”, Teteven, Bulgaria, Microbiological and physicochemical research of mountain spring water. Uttar Pradesh Journal of Zoology. 2022;43(12):16-29. doi: https://doi.org/10.56557/upjoz/2022/v43i123059
Zagorchev I, Budurov K. Stratigraphic problems of the Moesian Group (Upper Triassic, peri-Tethyan type), Bulgaria. Geologica Balcanica. 2023;1-2:31-53. doi: https://doi.org/10.52321/GeolBalc.36.1-2.31
Kulapong J, Theou O. Effects of probiotics and prebiotics on frailty and aging: A Narrative Review. Current Clinical Pharmacology. 2020;15(3):183-92. doi: https://doi.org/10.2174/1574884714666191120124548
Pietri P, Panagiota Th, Stefadis Ch. Environment: An old clue to the secret of longevity. Nature. 2017;544:7651. doi: https://doi.org/10.1038/544416e
Maier H, Jeune B, Vaupel JW. Exceptional Lifespans. In: Demographic Research Monographs. 2021. р. 1-344. doi: https://doi.org/10.1007/978-3-030-49970-9
Mincheva I, Naychov Zh, Radev C, et al. Ethnobotanical and ethnopharmacological study in the Bulgarian mountain Rhodopes: Part II-Contemporary use of medicinal plants. Diversity.2023;15(4):482. doi: https://doi.org/10.3390/d15040482
Aliberti SM, Funk RHW, Ciaglia E, Gonnella J, Giudice A, Vecchione C, et al. Old, Nonagenarians, and Centenarians in Cilento, Italy and the Association of Lifespan with the Level of Some Physicochemical Elements in Tap Drinking Water. Nutrients. 2023;15(1):218. doi: https://doi.org/10.3390/nu15010218
Ruiz-Arguello GJ, Sánchez-MedalL, Loría A, Piedras J, Córdova Red cell indices in normal adults residing at an altitude from sea level to 2670 meters. American Journal of Hematology. 1980;8(3):265-71. doi: https://doi.org/10.1002/ajh.2830080304
Li P, Wu J. Drinking water quality and human health. Exposure and Health. 2019;11:73-9. doi: https://doi.org/10.1007/s12403-019-00299-8
Rapant S, Letkovičová A, JurkovičováD, Kosmovský V, Kožíšek F, Jurkovič Differences in the health status of Slovak municipalities supplied with drinking water of different hardness values. Environmental Geochemistry and Health. 2021;43:2665-77. doi: https://doi.org/10.1007/s10653-020-00664-6
Liu L, Zheng Yi, Ruan H, et al. Drinking natural water unchangeably is associated with reduced all-cause mortality in elderly people: A longitudinal prospective study from China. Front. Public Health. 2022;10:981782. doi: https://doi.org/10.3389/fpubh.2022.981782
Yakimov I, Gruev I, Tsanova-Savova S. Changes of some cardio-vascular and respiratory parameters in football players in the state of dehydration and optimal hydration. Advances in Balkan Medical Union. 2016;51(3):358-61.
Mohr M, Nólsøe EL, Krustrup P, Fatouros IG, Jamurtas AZ. Improving Hydration in elite male footballers during a national team training camp – observation case study. Phys Act Nutr. 2021;25(4):10-6. doi: https://doi.org/10.20463/pan.2021.0021
Ignatov I, Angelcheva M, Angushev I. Doses of Са2+, Mg2+, K+, Nа+, Mn2+ and Zn2+ in mountain spring and mineral waters in hydration reaction during sports training and recovery; Combination with vitamins. Journal of Pharmaceutical Research International. 2021;33(16):76-85. doi: https://doi.org/10.9734/jpri/2021/v33i1631299
Steffl M, Kinkorova I, Talar K, Jandova T, Moulisova K, et al. The effects of high mineral alkaline water consumed over three consecutive days on reaction time following anaerobic exercise – A randomized placebo‐controlled crossover pilot study. Human Kinetics. 2021;78(1):111-9.
doi: https://doi.org/10.2478/hukin-2021-0046
Vescor G, Corominas J, Carceller A. Nutrition and Hydration for high-altitude alpinism: a narrative review. Int J Environ Res Public Health. 2023;20(4): 3186. doi: https://doi.org/10.3390/ijerph20043186

PDF

Authors and affiliations

Cite

Metrics

SOCIAL MEDICINE

Geanta M., Cucos B., Boata A., Nuta A.C., Nuta F.M., Semenov V.V. The Ukrainian war and the pandemic: the impact on public health and the need for new health digital tools and the next level of intelligence

https://doi.org/10.26641/2307-0404.2023.4.294241

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

A CASE FROM PRACTICE

Zhukovskiy V.S., Prokopiv O.V., Trutyak I.R., Pankiv M.V. Lymphoadenopathies caused by Bartonella henselae

https://doi.org/10.26641/2307-0404.2023.4.294276

Abstract

Bartonella henselae is the causative agent of cat scratch disease, the main manifestation of which is lymphadenopathy, but it can manifest as bacillary angiomatosis, injury to internal organs, joints, eyes, heart, kidneys. This disease is often encountered in the practical work of doctors, especially with an atypical form of the course, which occurs in 20% of adult patients. Often the disease is undiagnosed, mimicking lymphadenopathies caused by tumors of soft tissues and bones or other bacterial pathogens. The purpose of the work was to analyze clinical cases of cat scratch disease by the results of inpatient records data based on the leading clinical symptom – lymphadenitis, to summarize literature data related to morbidity, features of the clinical course and treatment of this disease. The description of two clinical cases of cat scratch disease in adult women aged 19 and 59 is given. The typical course of the disease in one of them at the beginning of the disease, was manifested by symptoms of general intoxication, fever, an increase of lymph nodes in the neck and axillary area, which coincided in time with the previously diagnosed bacterial angina. The diagnostic search ended with the set diagnosis and surgical operation three months after the onset of clinical manifestations of the disease. In the second case, a subfebrile body temperature, a painful lymph node in the right axillary area for 3 weeks were the reason to perform an invasive surgery twice for diagnosed bacterial process of unknown etiology. The reasons for late diagnosis and treatment of cat scratch disease in our patients were insufficient collection of epidemiological anamnesis, lack of vigilance of doctors, first of all, surgeons, regarding the clinical manifestations of the disease and late examination to find out the etiological factor of the disease. An elevated titer of IgM antibodies to Bartonella henselae 1:160 and 1:140 in two cases was the basis for confirming cat scratch disease. Based on the results of the literature analysis, an overview of typical and atypical manifestations of cat scratch disease, its diagnosis and treatment is presented. Bartonella henselae infection should be considered in all cases of lymphadenitis of unknown etiology, accompanied by high temperature, intoxication syndrome and a long course. In order to prevent the development of purulent complications and to avoid unreasonable invasive procedures, it is important to make a timely diagnosis and carry out appropriate antibacterial treatment at the initial stage of the manifestation of clinical symptoms of cat scratch disease.

Key words: Bartonella henselae, cat scratch disease, lymphadenitis, complication , atypical manifestations, treatment

References

CheslockMA, Monica EE. Human Bartonellosis: an underappreciated public health problem? Trop Med Infect Dis. 2019 Apr 19;4(2):69. doi: https://doi.org/10.3390/tropicalmed4020069
Carvajal JA, Yamasque AA, Piccolomini JP. [Hepato-splenic involvement, an unusual finding secondary to cat-scratch disease: a clinical case]. Arch Argent Pediatr. 2021 Oct;119(5):e540-e544. Spanish. doi: https://doi.org/10.5546/aap.2021.e540
Rodríguez Alonso B, Alonso-Sardón M, Rodrigues Almeida HM, Romero-Alegria Á, Pardo-Lledias J, Velasco-Tirado V, et al. Epidemiological of cat scratch disease among inpatients in the Spanish health system (1997-2015). Eur J Clin Microbiol Infect Dis. 2021 Apr;40(4):849-57. doi: https://doi.org/10.1007/s10096-020-04087-0
Tsuneoka H, Otsuyama KI, Motoki Y, Nojima J, Nishikawa J, Ichihara K. Exploring the seasonal and regional features of cat-scratch disease on the basis of anti-Bartonella henselae IgM/IgG positive rates in Japan. J Infect Chemother. 2022 Jan;28(1):112-5. doi: https://doi.org/10.1016/j.jiac.2021.09.003
Mennini M, Valentini D, Di Camillo C, Vittucci AC, Grandin A, Lancella L, et al. Bartonella henselae in Italy: a rare seasonal infection. Minerva Pediatr. 2019 Oct;71(5):415-9. doi: https://doi.org/10.23736/S0026-4946.16.04414-5
Theel ES, Ross T. Seasonality of Bartonella henselae IgM and IgG antibody positivity rates. J Clin Microbiol. 2019 Nov 22;57(12):e01263-19. doi: https://doi.org/10.1128/JCM.01263-19
Nelson CA, Saha S, Mead PS. Cat scratch disease in the United States, 2005–2013. Emerg Infect Dis. 2016;22(10):1741-6. doi: https://doi.org/10.3201/eid2210.160115
Baranowski K, Huang B. Cat Scratch Disease. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Apr 15]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482139/
Resto-Ruiz S, Burgess A, Anderson BE. The role of the host immune response in pathogenesis of Bartonella henselae. DNACell 2003;22(6):431-40. doi: https://doi.org/10.1089/104454903767650694
Maini R, Nagalli S. Lymphadenopathy. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Apr 15]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK558918/
Hozáková L, Rožnovský L, Fakhouri F, Doležílková J, Janout V. Lymph node syndrome associated with cat scratch disease in children and adults. Cas Lek Cesk. 2018;157(3):146-51. PMID: 30441948.
Maly VP, Asoyan I. [Generalized form of the cat scratch disease on the background of immunodefficiency with liver injury]. Infektsiyni Khvoroby. 2022;4:68-73. Ukrainian.
doi: https://doi.org/10.11603/1681-2727.2021.4.12842
Huarcaya E, Maguina C, Merello J, Cok J, Birtles R, Infante B, et al. A prospective study of cat scratch disease in Lima-Peru. Rev Inst Med Trop Sao Paulo. 2002 Nov-Dec;44(6):325-30. doi: https://doi.org/10.1590/S0036-46652002000600006
Montone KT. Infectious disease of the head and neck. Am J Clin Pathol. 2007;128(1):35-67. doi: https://doi.org/10.1309/6BBT12WGNK77N4EH
Maria HKS, Gazzoli E, Drummond MR, Almeida AR, Santos LSD, Pereira RM, et al. Two-year history of lymphadenopathy and fever caused by Bartonella henselae in a child. Rev Inst Med Trop Sao Paulo. 2022 Feb 16;64:e15. doi: https://doi.org/10.1590/S1678-9946202264015
LinsKA, Drummond MR, Ferreira PEN. Cutaneous manifestations of bartonellosis. An Bras Dermatol. 2019 Sep-Oct;94(5):594-602. doi: https://doi.org/10.1016/j.abd.2019.09.024
Uluğ M. Evaluation of cat scratch disease cases reported from Turkey between 1996 and 2013 and review of the literature. Cent Eur J Public Health. 2015;23(2):170-5. doi: https://doi.org/10.21101/cejph.a4040
DonàD, Fovino LN, Mozzo E, Cabrelle G, Bordin G, Lndin R, et al. Osteomyelitis in cat-scratch disease: a never-ending dilemma – a case report and literature review. Case Rep Pediatr. 2018;2018:1679306. doi: https://doi.org/10.1155/2018/1679306
Zhu M, Zhang S, Shi Q, Sun X, Zhang X, Wang H, et al. Swollen inguinal lymph nodes with low fever and night sweat: diagnosis and treatment of case of cat-scratch disease lymphadenitis with sinus formation. Heliyon.2022;8(9):e10448. doi: https://doi.org/10.1016/j.heliyon.2022.e10448
LemosAP, Domingues R, Gouveia C, de Sousa R, Brito Atypical bartonellosis in children: What do we know? J Paediatr Child Health. 2021 May;57(5):653-8. doi: https://doi.org/10.1111/jpc.15304
Nawrocki CC, Max RJ, Marzec NS, Nelson CA. Atypical manifestations of cat-scratch disease, United States, 2005-2014. Emerg Infect Dis. 2020 Jul 01;26(7):1438-46. doi: https://doi.org/10.3201/eid2607.200034
Salicio-Bermejo Y, Cilla-Eguiluz G, Blanco-Esteban A, Martin-Peñaranda T, Grandioso-Vas D, Echeverría-Irigoyen MJ. Neuroretinitis caused by Bartonella henselae in Gipuzkoa, 2014-2019. Enferm Infecc Microbiol Clin (Engl Ed). 2021 Nov;39(9):451-3. doi: https://doi.org/10.1016/j.eimce.2021.08.001
JurjaS, Stroe AZ, Pundiche MB, Axelerad SD, Mateescu G, Micu AO, et al. The clinical profile of cat-scratch disease’s neuro-ophthalmological effects. Brain Sci. 2022;12(2):217. doi: https://doi.org/10.3390/brainsci12020217
Nakamura M, Ura S, Yabe I, Otsuki M, Soma H, Ogata A. Cat scratch disease-associated encephalitis followed by parkinsonism. Intern Med. 2022;61:3115-20. doi: https://doi.org/10.2169/internalmedicine.9047-21
Canneti B, Cabo-López I, Puy-Núñez A, García García JC, Cores FJ, Trigo M, et al. Neurological presentations of Bartonella henselae infection. Neurol Sci. 2019 Feb;40(2):261-8. doi: https://doi.org/10.1007/s10072-018-3618-5
FangQ, Wang P, Qin S, Liu S, He Case report: Intracranial lesions of cat-scratch disease mimicking an atypical meningioma. Front Neurol. 2023 Feb 8;14:1080331. doi: https://doi.org/10.3389/fneur.2023.1080331
Agrawal SK, Das P, Shalimar, Swatantra G, Chaudhry R. Multifocal hepatic abscesses in immunocompetent patient due to Bartonella henselae: case report with review of literature. Indian J Med Microbiol. 2019;37(2):292-95. doi: https://doi.org/10.4103/ijmm.IJMM_19_4
Sharma R, Arshad A, Sardar S, Zafar Hepatosplenic Bartonellosis in an Immunocompetent Teenager: An Atypical Presentation of Cat-Scratch Disease. Cureus. 2021;13(2):e13219. doi: https://doi.org/10.7759/cureus.13219
FilipponiV, Trasarti S, Maccioni F, Zippi M, Busato L, Arienzo F, et al. Abdominal Lymphadenopathy: Hypothesize Cat-Scratch Disease and Avoid Abdominal Excisional Biopsy. Hemato. 2022;3(4):771-8. doi: https://doi.org/10.3390/hemato3040052
Yehudina Y, Trypilka S. Case reports of cat scratch disease in patient with unjustified surgical intervention. Cureus. 2021;13(4):e14632. doi: https://doi.org/10.7759/cureus.14632
DželalijaB, Petrovec M, Avšič-Županc Probable atypical cat scratch disease presenting as isolated posterior pancreatic duodenal lymphadenitis and abdominal pain. Clin Infect Dis. 2001;33(6):912-4. doi: https://doi.org/10.1086/322692
Kozak IO, Sukhodolia SA, Kozak LI, Ladyshkin VV. [Spontaneous splenic rupture]. Reports of Vinnytsia National Medical University. 2020;24(2):250-2. Ukrainian. doi: https://doi.org/10.31393/reports-vnmedical-2020-24(2)-09
Tay S, Freeman K, Baird R. Сlinical manifestations associated with Bartonella henselae infection in a tropical region. Am J Trop Med Hyg. 2021;104(1):198-206. doi: https://doi.org/10.4269/ajtmh.20-0088
King KY, Hicks MJ, Eldin KW, Starke JR, Michael Persistent cat scratch disease requiring surgical excision in a patient with MPGN. Pediatrics. 2015;135(6):1514-7. doi: https://doi.org/10.1542/peds.2014-2923
Erdem G, Watson JR, Hunt WG, Young C, SouverbielleCT, Honegger JR, et al. Clinical and radiologic manifestations of bone infection in children with cat-scratch disease. J Pediatr. 2018;201:274-80. doi: https://doi.org/10.1016/j.jpeds.2018.05.033
Kort JG, Robben SG, Schrander JJ, Rhijn LW. Multifocal osteomyelitis in a child: a rare manifestation of cat scratch disease: a case report and systematic review of the literature. J Pediatr Orthop B. 2006;15(4):285-8. doi: https://doi.org/10.1097/01202412-200607000-00010
RazafindrazakaH, Redl S, Aouchiche F, Grosleron S, Nazal-Traissac EM, Rispal P, et al. Bone involvement in cat scratch disease. Rev Med Interne. 2021 Dec;42(12):875-80. doi: https://doi.org/10.1016/j.revmed.2021.06.010
Allizond V, Costa C, Sidoti F, Scutera S, Bianco G, Sparti R, et al. Serological and molecular detection of Bartonella henselae in specimens from patients with suspected cat scratch disease in Italy: A comparative study. PloS ONE. 2019;14(2):e0211945. doi: https://doi.org/10.1371/journal.pone.0211945
Jost M, Latz A, Ballhorn W, Kempf VAJ. Development of a specific and sensitive enzyme-linked immunosorbent assay as an in vitro diagnostic tool for detection of bartonella henselae antibodies in human serum. J Clin Microbiol. 2018;56:e01329. doi: https://doi.org/10.1128/JCM.01329-18
Landes M, Maor Y, Mercer D, Habot-Wilner Z, Bilavsky E, Chazan B, et al. Cat Scratch Disease Presenting as Fever of Unknown Origin Is a Unique Clinical Syndrome. Clin Infect Dis. 2020 Dec 31;71(11):2818-24. doi: https://doi.org/10.1093/cid/ciz1137
Dhal U, Hicklen RS, Tarrand J, Kontoyiannis DP. Cat Scratch Disease as a Mimicker of Malignancy. Open Forum Infect Dis. 2021 Oct 5;8(11):ofab500. doi: https://doi.org/10.1093/ofid/ofab500
Bernard SA, Walker EA, Carroll JF, Klassen-Fischer M, Murphey MD. Epitrochlear cat scratch disease: unique imaging features allowing differentiation from other soft tissue masses of the medial arm. Skeletal Radiol. 2016;45(9):1227-34.
doi: https://doi.org/10.1007/s00256-016-2407-6
Chen Y, Fu YB, Xu XF, Pan Y, Lu CY, Zhu XL, et al. Lymphadenitis associated with cat-scratch disease simulating a neoplasm: imaging findings with histopathological associations. Oncol Lett. 2018 Jan;15(1):195-204. doi: https://doi.org/10.3892/ol.2017.7311
Amerstorfer F, Igrec J, Valentin T, Leithner A, Leitner L, Glehr M, et al. Cat at home? Cat scratch disease with atypical presentations and aggressive radiological findings mimicking sarcoma, a potential diagnostic pitfall. Acta Orthop.2021;92(6):753-9. doi: https://doi.org/10.1080/17453674.2021.1941624
GoazS, Rasis M, Ehrenreich IB, Shapira L, Halutz O, Graidy-Varon M, et al. Molecular diagnosis of cat scratch disease: a 25-year retrospective comparative analysis of various clinical specimens and different PCR assays. ASM Journals Microbiology Spectrum. 2022;10(2). doi: https://journals.asm.org/doi/pdf/10.1128/spectrum.02596-21
Pecora F, Abate L, Scavone S, Petrucci I, Costa F, Caminiti C, et al. Management of Infectious Lymphadenitis in Children. Children (Basel). 2021;8(10):860. doi: https://doi.org/10.3390/children8100860

PDF

Authors and affiliations

Cite

Metrics

Pokhylko V.I., Cherniavska Y.I., Fishchuk L.Y., Rossokha Z.I., Ievseienkova O.G., Dubitska O.M., Popova O.F., Fastovets M.М., Kaliuzhka O.О., Gorovenko N.G. Leiden mutation (rs6025) in a severe COVID-19 pneumonia patient with Down syndrome: a clinical case

https://doi.org/10.26641/2307-0404.2023.4.294283

Abstract

COVID-19 was first reported in December 2019 in Wuhan (Hubei Province, China). Later, the pandemic of this disease took the world by storm, challenging the medical community. Its clinical manifestations vary from asymptomatic to a severe course that requires hospitalization and intensive therapy with oxygen support. The mortality rate in patients with a severe course of COVID-19 can exceed 50% The majority of fatal cases of COVID-19 were associated with thrombotic events, despite the prophylactic use of anticoagulant therapy. Numerous theoretical overviews and research articles indicate the need for genetic testing in patients with COVID-19 to determine the genetic profile of proteins involved in thrombophilia. According to the researchers, the Leiden mutation (G1691A, rs6025) of the FV gene is one of the promising candidates for testing. The aim of the work was to demonstrate the clinical features of the severe course of COVID-19 in the presence of the Leiden mutation. 58 patients with COVID-19 of the intensive care unit were genotyped. The Leiden mutation in the heterozygous state was found only in one patient, who had Down syndrome. The Leiden mutation was detected with a frequency of 1.72% in the investigated group. The described clinical case clearly showed that individuals with Down syndrome, associated with hereditary thrombophilia are at risk of undesirable clinical consequences in the treatment of COVID-19. The condition of the patient with the Leiden mutation was severe when admitted to the hospital. The score according to the sequential organ failure assessment scale was 2 points. Bilateral multisegmental pneumonia was detected on the X-ray. On the second day after admission, due to the development of acute respiratory distress syndrome and multiple organ failure, the patient was transferred to the intensive care unit, where he received oxygen therapy through a facial mask. Medical treatment was carried out according to the protocol: non-steroidal anti-inflammatory drugs, antibacterial therapy, anticoagulants, sympathomimetics, and glucocorticosteroids. Despite the medical measures taken, progression of respiratory failure, renal failure, and portal hypertension was noted. On the 11th day, the patient developed asystole. Resuscitation measures were unsuccessful. Thus, the described case of a severe course of COVID-19 in a carrier of a heterozygous variant of the Leiden mutation with Down syndrome confirms the recommendations regarding the need for genetic testing for thrombophilia in high-risk groups and the appointment of personalized measures to prevent complications.

Key words: clinical case, COVID-19, Down syndrome, pneumonia, Leiden mutation, rs6025

References

Mainous AG, Rooks BJ, Wu V, Orlando FA. COVID-19 post-acute sequelae among adults: 12 month mortality risk. Front Med (Lausanne). 2021;8:778434. doi: https://doi.org/10.3389/fmed.2021.778434
Parra-Medina R, Herrera S, Mejia J. Systematic review of microthrombi in COVID-19 autopsies. Acta Haematol.2021;144(5):476-83. doi: https://doi.org/10.1159/000515104
Burlacu A, Genovesi S, Popa IV, Crisan-Dabija R. Unpuzzling COVID-19 prothrombotic state: are preexisting thrombophilic risk profiles responsible for heterogenous thrombotic events? Clin Appl Thromb Hemost.2020;26:1-5. doi: https://doi.org/10.1177/1076029620952884
Kiraz A, Sezer O, Alemdar A, Canbek S, Duman N, Bisgin A, et al. Contribution of genotypes in Prothrombin and Factor V Leiden to COVID-19 and disease severity in patients at high risk for hereditary thrombophilia. J Med Virol. 2023;95(2):e28457. doi: https://doi.org/10.1002/jmv.28457
Izmailova O, Shlykova O, Vatsenko A, Ivashchenko D, Dudchenko M, Koval T, et al. Allele С (rs5186) of AT1R is associated with the severity of COVID-19 in the Ukrainian population. Infect Genet Evol. 2022;98:1-7. doi: https://doi.org/10.1016/j.meegid.2022.105227
Fiore JR, Ciarallo M, Di Stefano M, Sica S, Scarale M, D'Errico M, et al. Severe systemic thrombosis in a young COVID-19 patient with a rare homozygous prothrombin G20210A mutation. Infez Med. 2021;29(2):259-62.
Stevens H, Canovas R, Tran H, Peter K, McFadyen JD. Inherited thrombophilias are associated with a higher risk of COVID-19-associated venous thromboembolism: a prospective population-based cohort study. Circulation.2022;145(12):940-2. doi: https://doi.org/10.1161/CIRCULATIONAHA.121.057394
Lapić I, Radić Antolic M, Horvat I, Remužić V, Palić J, Rogić D, et al. Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in COVID-19 patients: A pilot study. JMed 2022;94(8):3669-75. doi: https://doi.org/10.1002/jmv.27774
Kaminskyi VV, Vorobei LI, Zhdanovych OI, Korniienko SM, Kolomiichenko TV, Fastovets ОР. [Clinical and genetic determinants of severe course of COVID-19 in pregnant women]. Reprod endocrinol. 2022;3(65):38-43. Ukrainian.
doi: https://doi.org/10.18370/2309-4117.2022.65.38-43
Damar İH, Recep E, Kiliçaslan Ö. Frequency of hereditary prothrombotic risk factors in patients with Down syndrome. Konuralp Med J. 2021;13(1):89-93. doi: https://doi.org/10.18521/ktd.8239000
Turki RF, Assidi M, Banni HA, Zahed HA, Karim S, Schulten HJ, et al. Associations of recurrent miscarriages with chromosomal abnormalities, thrombophilia allelic polymorphisms and/or consanguinity in Saudi Arabia. BMC Med Genet. 2016;17(Suppl 1):69. doi: https://doi.org/10.1186/s12881-016-0331-1
Chiasakul T, De Jesus E, Tong J, Chen Y, Crowther M, Garcia D, et al. Inherited Thrombophilia and the Risk of Arterial Ischemic Stroke: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2019;8(19):1-12. doi: https://doi.org/10.1161/JAHA.119.012877
Tzoran I, Papadakis M, Brenner B, Fidalgo Á, Rivas A, Wells PS, et al. Outcome of Patients with Venous Thromboembolism and Factor V Leiden or Prothrombin 20210 Carrier Mutations During the Course of Anticoagulation. Am J Med. 2017;130(4):482.e1-482.e9. doi: https://doi.org/10.1016/j.amjmed.2016.11.016
Colucci G, Tsakiris DA. Thrombophilia Screening: Universal, Selected, or Neither? Clin Appl Thromb Hemost.2017;23(8):893-9. doi: https://doi.org/10.1177/1076029616683803
Fishchuk L, Rossokha Z, Pokhylko V, Cherniavska Y, Popova O, Vershyhora V, et al. SFTPB (rs11130866) and NR3C1 (rs41423247) gene variants as potential clinical biomarkers for personalized treatment strategy selection in patients with severe COVID-19 pneumonia. Respir Investig. 2023;61(1):103-9. doi: https://doi.org/10.1016/j.resinv.2022.10.008
Arachchillage DJ, Mackillop L, Chandratheva A, Motawani J, MacCallum P, Laffan M. Thrombophilia testing: A British Society for Haematology guideline. Br J Haematol. 2022;98(3):443-58. doi: https://doi.org/10.1111/bjh.18239
Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost. 2005;3(2):292-9. doi: https://doi.org/10.1111/j.1538-7836.2005.01141.x
[Algorithm for providing hospital medical care in case of COVID-19] [Internet]. 2021 [cited 2023 Feb 12]. Ukrainian. Available from: https://moz.gov.ua/uploads/7/35121-algoritm_stac_covid_19.pdf
Fishchuk L, Rossokha Z, Medvedieva N, Vershyhora V, Sheyko L, Brisevac L, et al. Effect of polymorphic variants of hereditary thrombophilia genes on the risk of early pregnancy loss for married couples. Meta Gene. 2021;29:100902. doi: https://doi.org/10.1016/j.mgene.2021.100902
Huang MY, Fang WY, Lee SC, Cheng TL, Wang JY, Lin SR. ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study. BMC Cancer. 2008;8:50. doi: https://doi.org/10.1186/1471-2407-8-50
Badulescu OV, Sirbu PD, Filip N, Bordeianu G, Cojocaru E, Budacu CC, et al. Hereditary thrombophilia in the era of COVID-19. Healthcare (Basel). 2022;10(6):993. doi: https://doi.org/10.3390/healthcare10060993
Heeb MJ, Kojima Y, Greengard JS, Griffin JH. Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V. Blood. 1995;85(12):3405-11. doi: https://doi.org/10.1182/blood.V85.12.3405.bloodjournal85123405
Msalati A, Bashein A, Ghrew M, Khalil I, Sedaa K, Ali A, et al. Association of venous thromboembolism and myocardial infarction with Factor V Leiden and Factor II gene mutations among Libyan patients. Libyan J Med. 2021;16(1):1857525. doi: https://doi.org/10.1080/19932820.2020.1857525
Jusić A, Balić D, Avdić A, Pođanin M, Balić A. The association of factor V G1961A (factor V Leiden), prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Bosnian women. Med Glas (Zenica). 2018;15(2):158-63. doi: https://doi.org/10.17392/948-18
Ahmed NA, Adam I, Elzaki SEG, Awooda HA, Hamdan HZ. Factor-V Leiden G1691A and prothrombin G20210A polymorphisms in Sudanese women with preeclampsia, a case-control study. BMC Med Genet. 2019;20(1):2. doi: https://doi.org/10.1186/s12881-018-0737-z
Amara A, Mrad M, Sayeh A, Haggui A, Lahideb D, Fekih-Mrissa N, et al. Association of FV G1691A polymorphism but not A4070G with coronary artery disease. Clin Appl Thromb Hemost. 2018;24(2):330-7. doi: https://doi.org/10.1177/1076029617744320
AbdelAziz NH, AbdelAzeem HG, Monazea EM, Sherif T. Impact of Thrombophilia on the Risk of Hypoxic-Ischemic Encephalopathy in Term Neonates. Clin Appl Thromb Hemost. 2017;23(3):266-73. doi: https://doi.org/10.1177/1076029615607302
Elmas E, Suvajac N, Jilma B, Weiler H, Borggrefe M, Dempfle CE. Factor V Leiden mutation enhances fibrin formation and dissolution in vivo in a human endotoxemia model. Blood. 2010;116(5):801-5. doi: https://doi.org/10.1182/blood-2009-03-21321
Rossokha Z, Fishchuk L, Sheyko L, Medvedieva N, Gorovenko N. Positive effect of betaine-arginine supplement on improved hyperhomocysteinemia treatment in married couples with reproductive disorders. Georgian Med News. 2020;309:22-8.
Tatarskyy P, Kucherenko A, Livshits L. Allelic polymorphism of F2, F5 and MTHFR genes in population of Ukraine. Tsitol Genet. 2010;44(3):3-8. doi: https://doi.org/10.3103/S0095452710030011
Hüls A, Costa ACS, Dierssen M, Baksh RA, Bargagna S, Baumer NT, et al. Medical vulnerability of individuals with Down syndrome to severe COVID-19-data from the Trisomy 21 Research Society and the UK ISARIC4C survey. eClinicalMedicine. 2021;33:100769. doi: https://doi.org/10.1016/j.eclinm.2021.100769
Clift AK, Coupland CAC, Keogh RH, Hemingway H, Hippisley-Cox J. COVID-19 Mortality risk in Down syndrome: results from a cohort study of 8 million adults. Ann Intern Med. 2021;174(4):572-6. doi: https://doi.org/10.7326/M20-4986
Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, et al. Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021;(4):561-71. doi: https://doi.org/10.1007/s12017-021-08651-5
Robayo-Amortegui H, Valenzuela-Faccini N, Quecano-Rosas C, et al. Cerebral venous thrombosis in a patient with Down syndrome and coronavirus disease 2019: a case report. J Med Case Rep. 2021;15(1):364. doi: https://doi.org/0.1186/s13256-021-02908-0

CONTENT OF ISSUES

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract

References

PDF

Authors and affiliations

Cite

Metrics

Abstract